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Source: Biochimica et Biophysica Acta
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Total 177 results found since Jan 2013.
Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
In conclusion, our findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements and neuroprotective effects against 3-NP toxicity in cortical neurons. OSM may thus serve as a novel neuroprotective agent against mitochondrial dysfunction commonly associated with pathogenic mechanisms underlying neurodegeneration.
PMID: 25986861 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - May 15, 2015 Category: Biochemistry Authors: Chang SH, Hwang CS, Yin JH, Chen S, Yang DI Tags: Biochim Biophys Acta Source Type: research
Histone deacetylase HDAC1 downregulates transcription of the serotonin transporter (5-HTT) gene in tumor cells.
In this study, we examined the expression of the serotonin transporter (5-HTT) and the role of histone deacetylases (HDACs) in regulating the 5-HTT gene in tumor cells. The 5-HTT gene expression was almost silenced in chicken lymphoma DT40, myelomonocytic tumor HD11 and hepatoma DU249 cells, compared to their physiological counterpart. In contrast, HDAC1 mRNA expression was increased in these cell lines. Indeed, the pan-HDAC inhibitor trichostatin A (TSA) enhanced the 5-HTT mRNA expression in several tumor cell lines including the human cell lines HepG2 and THP-1 and increased the 5-HT uptake in HD11 cells. In addition, tr...
Source: Biochimica et Biophysica Acta - May 26, 2015 Category: Biochemistry Authors: Phi van DK, Mühlbauer E, Phi-van L Tags: Biochim Biophys Acta Source Type: research
TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell line.
In conclusion, this study demonstrates for the first time the expression of TRPV6 in INS-1E cells and rat pancreatic beta cells and describes its role in modulating calcium signaling, beta cell proliferation and insulin mRNA expression. In contrast, TRPV6 fails to influence insulin secretion.
PMID: 26384871 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - September 16, 2015 Category: Biochemistry Authors: Skrzypski M, Khajavi N, Mergler S, Szczepankiewicz D, Kołodziejski PA, Metzke D, Wojciechowicz T, Billert M, Nowak KW, Strowski MZ Tags: Biochim Biophys Acta Source Type: research
Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy.
Abstract
Retinal pericyte loss and neovascularization are characteristic features of diabetic retinopathy. Gemigliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, has shown robust blood-glucose lowering effects in type 2 diabetic patients, but its effects on diabetic retinopathy have not yet been reported. We evaluated the efficacy of gemigliptin on retinal vascular leakage in db/db mice, which is an animal model for type 2 diabetes, and neovascularization in oxygen-induced retinopathy (OIR) mice, which is an animal model for ischemic proliferative retinopathy. Gemigliptin (100mg/kg/day) was orally administered t...
Source: Biochimica et Biophysica Acta - September 18, 2015 Category: Biochemistry Authors: Jung E, Kim J, Kim CS, Kim SH, Cho MH Tags: Biochim Biophys Acta Source Type: research
Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade.
In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). BLT2 depletion with siRNA clearly abolished the chemoresistance to cisplatin in SK-OV-3 ovarian cancer cells and further increased cell sensitivity to cisplatin chemotherapy by down-regulating the 'STAT-3-IL-6' cascade. Enlarged tumor formatio...
Source: Biochimica et Biophysica Acta - November 17, 2015 Category: Biochemistry Authors: Park J, Park SY, Kim JH Tags: Biochim Biophys Acta Source Type: research
Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration.
Abstract
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid, which plays a crucial role in the regulation of cell proliferation, migration, and differentiation. LPA exerts its biological effects mainly through binding to cell-surface LPA receptors (LPA1-6), which belong to the G protein-coupled receptor (GPCR) family. Recent studies suggest that cross-talk between receptor tyrosine kinases (RTKs) and GPCRs modulates GPCRs-mediated signaling. Tropomyosin receptor kinase A (TrkA) is a RTK, which mediates nerve growth factor (NGF)-induced biological functions including cell migration in neuronal and non-neur...
Source: Biochimica et Biophysica Acta - November 17, 2015 Category: Biochemistry Authors: Nan L, Wei J, Jacko AM, Culley MK, Zhao J, Natarajan V, Ma H, Zhao Y Tags: Biochim Biophys Acta Source Type: research
Mineralocorticoid receptor mediated liposomal delivery system for targeted induction of apoptosis in cancer cells.
In conclusion, this study presents MR as a target for efficiently delivering anticancer genes and thereby treating cancer through MR-mediated pathway.
PMID: 26620075 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 24, 2015 Category: Biochemistry Authors: Sharma P, Banerjee R, Narayan KP Tags: Biochim Biophys Acta Source Type: research
Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways.
Abstract
Taxanes can induce drug resistance by increasing signalling pathways such as PI3K/Akt and ERK, which promote survival and cell growth in human cancer cells. We have previously shown that long chain n-3 polyunsaturated fatty acids, such as docosahexaenoic acid (DHA, 22:6n-3) decrease resistance of experimental mammary tumors to anticancer drugs. Our objective was to determine whether DHA could increase tumor sensitivity to docetaxel by down-regulating these survival pathways. In docetaxel-treated MDA-MB-231 cells, phosphorylated-ERK1/2 levels were increased by 60% in membrane and nuclear compartments, comp...
Source: Biochimica et Biophysica Acta - January 25, 2016 Category: Biochemistry Authors: Lucie C, Goupille C, Charly B, Michelle P, Isabelle D, Cyrille G, Philippe B, Stephan C, Karine M Tags: Biochim Biophys Acta Source Type: research
Activation of autophagy by globular adiponectin is required for muscle differentiation.
Abstract
Regulated autophagy is a critical component for a healthy skeletal muscle mass, such that dysregulation of the autophagic processes correlates with severe myopathies. Thus, defining the biological molecules involved in the autophagic processes within skeletal muscle is of great importance. Here we demonstrate that globular adiponectin (gAd) activates autophagy in skeletal muscle myoblasts via an AMPK-dependent mechanism. Activation of autophagy through gAd promotes myoblast survival and apoptosis inhibition during serum starvation and the gAd-activated autophagy orchestrates the myogenic properties of the...
Source: Biochimica et Biophysica Acta - January 26, 2016 Category: Biochemistry Authors: Gamberi T, Modesti A, Magherini F, D'Souza DM, Hawke T, Fiaschi T Tags: Biochim Biophys Acta Source Type: research
Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis.
CONCLUSIONS: LMWHA/RHAMM downstream signaling regulates fibrosarcoma cell growth in a β-catenin/c-myc dependent manner.
GENERAL SIGNIFICANCE: The present study suggests that RHAMM is a novel β-catenin intracellular binding partner, protecting β-catenin from degradation and supporting the nuclear translocation of this key cellular mediator, which results in c-myc activation and enhanced fibrosarcoma cell growth.
PMID: 26825774 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 26, 2016 Category: Biochemistry Authors: Kouvidi K, Berdiaki A, Tzardi M, Karousou E, Passi A, Nikitovic D, Tzanakakis GN Tags: Biochim Biophys Acta Source Type: research
Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function.
Abstract
Mutations in hepatocyte nuclear factor 1 transcription factors (HNF1α/β) are associated with diabetes. These factors are well studied in the liver, pancreas and kidney, where they direct tissue-specific gene regulation. However, they also have an important role in the biology of many other tissues, including the intestine. We investigated the transcriptional network governed by HNF1 in an intestinal epithelial cell line (Caco2). We used chromatin immunoprecipitation followed by direct sequencing (ChIP-seq) to identify HNF1 binding sites genome-wide. Direct targets of HNF1 were validated using convention...
Source: Biochimica et Biophysica Acta - February 6, 2016 Category: Biochemistry Authors: Yang R, Kerschner JL, Harris A Tags: Biochim Biophys Acta Source Type: research
Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms.
CONCLUSIONS: These results support the potential of HT as a chondroprotective nutraceutical compound against OA, not merely for its antioxidant ability, but as an autophagy and SIRT-1 inducer as well.
GENERAL SIGNIFICANCE: HT may exert a cytoprotective action by promoting autophagy in cell types that may be damaged in degenerative diseases by oxidative and other stress stimuli.
PMID: 26947008 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 3, 2016 Category: Biochemistry Authors: Cetrullo S, D'Adamo S, Guidotti S, Borzì RM, Flamigni F Tags: Biochim Biophys Acta Source Type: research
The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1.
Abstract
The TIR/BB-loop mimetic AS-1 has been reported to prevent cardiac hypertrophy by inhibiting interleukin-1 receptor (IL-1R)-mediated myeloid differentiation primary response gene 88 (MyD88)-dependent signaling. To date, it remains unknown whether and if so how AS-1 contributes to mechanical stress (MS)-induced cardiac fibroblast activation, a key process in pressure overload-induced cardiac remodeling and heart failure. Here, we show that phosphorylation and expression of large tumor suppressor kinase 1 (LATS1), a key molecule in the Hippo-Yes associated protein (YAP) signaling pathway, were down-regulated...
Source: Biochimica et Biophysica Acta - March 7, 2016 Category: Biochemistry Authors: Fan M, Song J, He Y, Shen X, Li J, Que L, Zhu G, Zhu Q, Cai X, Ha T, Chen Q, Xu Y, Li C, Li Y Tags: Biochim Biophys Acta Source Type: research
Oxidative stress and glyoxalase-1 activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative.
CONCLUSIONS: Dicarbonyl toxicity was mediated by oxidative stress and GLO-1 activity determines aldehyde toxicity in tamoxifen resistant cells.
GENERAL SIGNIFICANCE: Glyoxalases might be predictive biomarkers for tamoxifen resistance and a putative target for the treatment of tamoxifen resistant breast cancer patients.
PMID: 26971627 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 10, 2016 Category: Biochemistry Authors: Nass N, Sel S, Ignatov A, Roessner A, Kalinski T Tags: Biochim Biophys Acta Source Type: research
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3.
CONCLUSION: Altogether the results are consistent with a model whereby both constitutive and ligand-induced internalization of ErbB3 are regulated through interaction with epsin 1.
GENERAL SIGNIFICANCE: Internalization is an important regulator of growth factor receptor mediated signaling and the current study identify mechanisms regulating plasma membrane turnover of ErbB3.
PMID: 26975582 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 11, 2016 Category: Biochemistry Authors: Szymanska M, Fosdahl AM, Raiborg C, Dietrich M, Liestøl K, Stang E, Bertelsen V Tags: Biochim Biophys Acta Source Type: research
