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Source: Journal of Cellular Physiology
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Total 116 results found since Jan 2013.
Prostaglandin E2‐Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor‐β‐Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration
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Source: Journal of Cellular Physiology - May 1, 2016 Category: Cytology Authors: Casimiro Gerarduzzi, QingWen He, Beibei Zhai, John Antoniou, John A. Di Battista Tags: Original Research Article Source Type: research
Runx2/DICER/miRNA Pathway in Regulating Osteogenesis
In conclusion, our results suggest that DICER is specifically regulated by osteogenic master gene Runx2 that binds to the DICER promoter. Consequently, DICER cleaves precursors of miR‐335‐5p and miR‐17‐92 cluster to form mature miRNAs, which target and decrease the Dickkopf‐related protein 1 (DKK1) and proapoptotic factor BIM levels, respectively, leading to an enhanced Wnt/β‐catenin signaling pathway. These intriguing results reveal a central mechanism underlying lineage‐specific regulation by a Runx2/DICER/miRNAs cascade during osteogenic differentiation and bone development. Our study also suggests a pote...
Source: Journal of Cellular Physiology - April 11, 2016 Category: Cytology Authors: Leilei Zheng, Qisheng Tu, Shu Meng, Lan Zhang, Liming Yu, Jinlin Song, Yun Hu, Lei Sui, Jin Zhang, Michel Dard, Jessica Cheng, Dana Murray, Jane Lian, Gary Stein, Jake Chen Tags: Original Research Article Source Type: research
The Androgen Receptor Regulates PPAR γ Expression and Activity in Human Prostate Cancer Cells
The peroxisome proliferator activated receptor gamma (PPARγ) is a ligand‐activated transcription factor that regulates growth and differentiation within normal prostate and prostate cancers. However the factors that control PPARγ within the prostate cancers have not been characterized. The goal of this study was to examine whether the androgen receptor (AR) regulates PPARγ expression and function within human prostate cancer cells. qRT‐PCR and Western blot analyses revealed nanomolar concentrations of the AR agonist dihydrotestosterone (DHT) decrease PPARγ mRNA and protein within the castration‐resistant, AR‐po...
Source: Journal of Cellular Physiology - March 13, 2016 Category: Cytology Authors: Emuejevoke Olokpa, Adrienne Bolden, LaMonica V. Stewart Tags: Original Research Article Source Type: research
The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells
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Source: Journal of Cellular Physiology - March 4, 2016 Category: Cytology Authors: Emuejevoke Olokpa, Adrienne Bolden, LaMonica V. Stewart Tags: Original Research Article Source Type: research
Involvement of Transient Receptor Potential Cation Channel Vanilloid 1 (TRPV1) in Myoblast Fusion
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Source: Journal of Cellular Physiology - February 18, 2016 Category: Cytology Authors: Mitsutoshi Kurosaka, Yuji Ogura, Toshiya Funabashi, Tatsuo Akema Tags: Original Research Article Source Type: research
miR‐19a, ‐19b, and ‐26b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation
This study is the first to demonstrate crosstalk between MAPK activation and reduction in miR‐19a, ‐19b, and ‐26b expression leading to lung fibroblast differentiation. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - February 12, 2016 Category: Cytology Authors: Yen‐Chou Chen, Bin‐Chang Chen, Chung‐Chi Yu, Shin‐Hua Lin, Chien‐Huang Lin Tags: Original Research Article Source Type: research
Expression of Ribosomal RNA and Protein Genes in Human Embryonic Stem Cells Is Associated with the Activating H3K4me3 Histone Mark
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Source: Journal of Cellular Physiology - January 11, 2016 Category: Cytology Authors: Sayyed K. Zaidi, Joseph R. Boyd, Rodrigo Grandy, Ricardo Medina, Jane B. Lian, Gary S. Stein, Janet L. Stein Tags: Original Research Article Source Type: research
CD44 Influences Fibroblast Behaviors Via Modulation of Cell–Cell and Cell–Matrix Interactions, Affecting Survivin and Hippo Pathways
CD44 has been studied in a wide variety of cell types, in a diverse array of cell behaviors and in a diverse range of signaling pathways. We now document a role for CD44 in mediating fibroblast behaviors via regulation of N‐cadherin, extracellular matrix expression, Survivin and the Hippo pathway. Here, we report our findings on the roles of CD44 in modulating proliferation, apoptosis, migration and invasion of murine wild‐type (WT‐FB) and CD44 knockout dermal fibroblasts (CD44KO‐FB). As we have documented in microvascular endothelial cells lacking CD44, we found persistent increased proliferation, reduced activati...
Source: Journal of Cellular Physiology - November 23, 2015 Category: Cytology Authors: Masayuki Tsuneki, Joseph A. Madri Tags: Original Research Article Source Type: research
The Transcription Factor EB (TFEB) Regulates Osteoblast Differentiation through ATF4/CHOP‐Dependent Pathway
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Source: Journal of Cellular Physiology - November 1, 2015 Category: Cytology Authors: Erika Yoneshima, Kuniaki Okamoto, Eiko Sakai, Kazuhisa Nishishita, Noriaki Yoshida, Takayuki Tsukuba Tags: Original Research Article Source Type: research
Acetylcholine Attenuates Hypoxia/Reoxygenation Injury by Inducing Mitophagy through PINK1/Parkin Signal Pathway in H9c2 Cells
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Source: Journal of Cellular Physiology - October 14, 2015 Category: Cytology Authors: Lei Sun, Mei Zhao, Yang Yang, Run‐Qing Xue, Xiao‐Jiang Yu, Jian‐Kang Liu, Wei‐Jin Zang Tags: Original Research Article Source Type: research
S100A8, An Oocyte‐Specific Chemokine, Directs the Migration of Ovarian Somatic Cells During Mouse Primordial Follicle Assembly
This study was performed to address this issue. Firstly, in an in vitro reconstruction system, dispersed ovarian cells from murine fetal ovaries at 19.0 days post coitum (dpc) reassembled into follicle‐like structures, independent of the physical distance between the cells, implying that either oocytes or ovarian somatic cells (OSCs) were motile. We then carried out a series of transwell assay experiments, and determined that it was in fact 19.0 dpc OSCs (as opposed to oocytes), which exhibited a significant chemotactic response to both fetal bovine serum and oocytes themselves. We observed that S100A8, a multi‐funct...
Source: Journal of Cellular Physiology - August 24, 2015 Category: Cytology Authors: Zhen Teng, Chao Wang, Yijing Wang, Kun Huang, Xi Xiang, Wanbao Niu, Lizhao Feng, Lihua Zhao, Hao Yan, Hua Zhang, Guoliang Xia Tags: Original Research Article Source Type: research
CD44 Influences Fibroblast Behaviors Via Modulation of Cell‐Cell and Cell‐Matrix Interactions, Affecting Survivin and Hippo Pathways
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Source: Journal of Cellular Physiology - August 6, 2015 Category: Cytology Authors: Masayuki Tsuneki, Joseph A. Madri Tags: Original Research Article Source Type: research
TGF‐β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells
Ift88 is an intraflagella transport protein, critical for the cilium, and has been shown to be required for the maintenance of chondrocytes and cartilage. However, how Ift88 is controlled by cytokines that play a role in osteoarthritis is not well understood. Therefore, we examined the effects of TGF‐β on the expression of Ift88. We used ATDC5 cells as chondrocytes and analyzed the effects of TGF‐β on gene expression. TGF‐β treatment suppresses the levels of Ift88 mRNA in a dose‐dependent manner starting from as low as 0.5 ng/mL and reaching the nadir at around 2 ng/mL. TGF‐β treatment also suppresses the...
Source: Journal of Cellular Physiology - July 27, 2015 Category: Cytology Authors: Makiri Kawasaki, Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Yayoi Izu, Masaki Noda Tags: Original Research Article Source Type: research
Potential Role of Glycogen Synthase Kinase‐3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells
This study therefore aimed to examine whether and how inhibition of GSK‐3β regulates myocardin activity in human vascular SMCs. Treatment of SMCs with the GSK‐3β inhibitors AR‐A014418 and TWS 119 significantly reduced endogenous myocardin activity, as indicated by lower expression of myocardin target genes (and gene products), CNN1 (calponin), TAGLN1 (SM22) and ACTA2 (SM α‐actin). In human SMCs overexpressing myocardin through the T‐REx system, treatment with either GSK‐3β inhibitor also inhibited the expression of CNN1, TAGLN1 and ACTA2. These effects of GSK‐3β inhibitors were mimicked by transfection w...
Source: Journal of Cellular Physiology - June 30, 2015 Category: Cytology Authors: Yi‐xia Zhou, Zhan Shi, Pavneet Singh, Hao Yin, Yan‐ni Yu, Long Li, Michael P. Walsh, Yu Gui, Xi‐Long Zheng Tags: Original Research Article Source Type: research
Critical Role of AMPK/FoxO3A Axis in Globular Adiponectin‐Induced Cell Cycle Arrest and Apoptosis in Cancer Cells
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Source: Journal of Cellular Physiology - June 18, 2015 Category: Cytology Authors: Anup Shrestha, Saroj Nepal, Mi Jin Kim, Jae Hoon Chang, Sang‐Hyun Kim, Gil‐Saeng Jeong, Chul‐Ho Jeong, Gyu Hwan Park, Sunghee Jung, Jaecheong Lim, Eunha Cho, Soyoung Lee, Pil‐Hoon Park Tags: Original Research Article Source Type: research
