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Source: Journal of Cellular Physiology
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Total 116 results found since Jan 2013.
Invasiveness ‐triggered state transition in malignant melanoma cells
AbstractCancer cells are considered to have high morphological heterogeneity in human melanoma tissue. Here, we report that epithelial cancer cells are dominant in different development stages of human melanoma tissues. The cellular and molecular mechanisms that maintain melanoma cells in the epithelial state are further investigated in the A2058 cell line. We find that micropore (8 µm) transwell invasion, but not superficial migration in the scratch assay, can induce remarkable morphological changes between epithelial and mesenchymal melanoma cells within 4 days. The morphological switch is associated with dynamic cha...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Huan Wang,
Yan ‐Guo Zhang,
Jing Ma,
Jun‐Chang Li,
Jian Zhang,
Yao‐Qing Yu Tags: RAPID COMMUNICATION Source Type: research
miR ‐150 might inhibit cell proliferation and promote cell apoptosis by targeting LMO4 in Burkitt lymphoma
This study aimed at investigating the effect of microRNA ‐150 (miR‐150) on cell proliferation of Burkitt lymphoma and its molecular mechanism. Gene expression analysis was applied to identify target genes of miR‐150 in Burkitt lymphoma cell line ST486 based on the dataset from the Gene Expression Omnibus (GEO) datasets GSE86432. miRNA mimics, inhibi tor and small interfering RNA (siRNA) were fluorescently labeled by Cy3, whereas plasmid vector was labeled by EGFP. Cells were viewed by fluorescence microscope and transfection efficiency was evaluated through fluorescent cell percentage. Quantitative real‐time polym...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Dandan Zhang,
Yanshuan Wei,
Jun Zhou,
Guannan Wang,
Lin Xiao,
Jingjing Xu,
Na Wei,
Wencai Li,
Mingzhi Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pulsed electromagnetic fields regulate osteocyte apoptosis, RANKL/OPG expression, and its control of osteoclastogenesis depending on the presence of primary cilia
This study enriches our basic knowledge for further understanding the biological behaviors of osteocytes, and is also helpful for providing a more comprehensive mechanistic understanding of the effect of electromagnetic stimulation on bone and relevant skeletal diseases (e.g., bone fractu re and osteoporosis). AbstractGrowing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts and osteoclasts in vitro. Osteocytes, accounting for 95% of bone cells, act as the major mechanosensors in bone for transducing external mechanical signals and p...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Pan Wang,
Chi Tang,
Junjie Wu,
Yuefan Yang,
Zedong Yan,
Xiyu Liu,
Xi Shao,
Mingming Zhai,
Jie Gao,
Shengru Liang,
Erping Luo,
Da Jing Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Cancer stem cells (CSCs) in cancer progression and therapy
Most of the tumors are occupied with a number of self ‐renewing cells called cancer stem cells (CSCs) that are contributed to the initiation, maintenance, and thriving cancer. The cells have rather similar characteristics to other stem cells located in the niche of body organs, but they have not essentially the same responses to the diverse stimuli. There is evidence for repopulation of CSCs after treatment with chemo/radiotherapy, which is possibly because of their highly plastic feature. Normal stem cells have the proclivity to transform into CSCs when they undergo continuous mutagenesis or receive tumorigenic signals ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Masoud Najafi,
Bagher Farhood,
Keywan Mortezaee Tags: REVIEW ARTICLE Source Type: research
Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR ‐181b/SIRT1/HO‐1 signaling
This study aimed to investigate the role and underlying mechanism of LA in the abdominal aortic aneurysm (AAA). AAA model was established by continuous infusion of 1000 ng/kg/min of angiotensin II (AngII) in ApoE‐/‐ mice for 4 weeks. At 7 days before AngII administration, 5 mg/kg/day or 10 mg/kg/day of LA was intraperitoneally administered to mice and continued for 4 weeks. The characteristics and quantification of AAAs were determined in situ. Real‐time PCR or western blot was used to measure mRNA or protein levels of matrix metalloproteinase 2 and matrix metal loproteinase 9; pro‐inflammatory cytokines tum...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Xuhui Hou,
Songbai Yang,
Yan Zheng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Effects of microRNA ‐217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4‐induced liver injury by targeting NAT2
This study aims to explore the effects of miR ‐217 targeting NAT2 on hepatocyte proliferation, apoptosis, and autophagy following carbon tetrachloride (CCL4)‐induced liver injury. Rat models of CCL4‐induced liver injury were established. Healthy Wistar rats were randomized into the normal, blank, negative control (NC), microRNA‐217 (miR ‐217) mimic, miR‐217 inhibitor, small interfering RNA (siRNA)‐N‐acetyltransferase 2 (NAT2), and miR‐217 inhibitor + siRNA‐NAT2 groups. NAT2 activity was evaluated with reversed‐phase high‐performance liquid chromatographic method. Immunohistochemistry was used t...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Cheng ‐Liang Yang,
Xiao‐Li Zheng,
Ke Ye,
Ya‐Nan Sun,
Yu‐Fei Lu,
Hong Ge,
Hui Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro
Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - August 22, 2018 Category: Cytology Authors: HabibZarredar
,
ShadiPashapour
,
KhalilAnsarin
,
MajidKhalili
,
RoghayyehBaghban
,
SafarFarajnia Source Type: research
Increased N6 ‐Methyladenosine causes infertility is associated with FTO expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 31, 2018 Category: Cytology Authors: Chenyue Ding, Qinyan Zou, Jie Ding, Mingfa Ling, Wei Wang, Hong Li, Boxian Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Calcium ‐sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 18, 2018 Category: Cytology Authors: Amanda D'Espessailles, Yuly A Mora, Cecilia Fuentes, Mariana Cifuentes Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ADAM17 Participates in the Protective Effect of Paeoniflorin on Mouse Brain Microvascular Endothelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Haifang Wang, Shuhui Ma, Jing Li, Miaomiao Zhao, Xueping Huo, Jingying Sun, Lijun Sun, Jun Hu, Qinshe Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Effects of small interfering RNA targeting TLR4 on expressions of adipocytokines in obstructive sleep apnea hyponea syndrome with hypertension in a rat model
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Jing ‐Guo Wu, Nan Xun, Li‐Jin Zeng, Zhen‐Yu Li, Yan‐Bing Liang, Hao Tang, Zhong‐Fu Ma Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Protective effect of epigenetic silencing of CyclinD1 against spinal cord injury using bone marrow ‐derived mesenchymal stem cells in rats
Conclusion: Our study provides evidence that epigenetic silencing of CyclinD1 using BMSCs might accelerate the repair of SCI in rats. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Yuan Wang, Qing ‐Jie Kong, Jin‐Chuan Sun, Xi‐Ming Xu, Yong Yang, Ning Liu, Jian‐Gang Shi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
FGF ‐2 promotes osteocyte differentiation through increased E11/podoplanin expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Ekele Ikpegbu, Lena Basta, Dylan N. Clements, Robert Fleming, Tonia L. Vincent, David J. Buttle, Andrew A. Pitsillides, Katherine A. Staines, Colin Farquharson Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Inhibition of HSP90 α protects cultured neurons from oxygen‐glucose deprivation induced necroptosis by decreasing RIP3 expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - November 20, 2017 Category: Cytology Authors: Zhen Wang, Li ‐min Guo, Yong Wang, Hong‐kang Zhou, Shu‐chao Wang, Dan Chen, Ju‐fang Huang, Kun Xiong Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Epithelial Cell Adhesion Molecule Fragments and Signaling in Primary Human Liver Cells
In conclusion, signaling through the intracellular domain of EpCAM appears to be a mechanism that induces proliferation specifically in tumorigenic cells but not in normal primary EpCAM‐positive liver cells. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - November 18, 2017 Category: Cytology Authors: J örg C. Gerlach, Hubert G. Foka, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
