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Source: Journal of Cellular Biochemistry

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Total 134 results found since Jan 2013.

Synergistic effect of siRNA ‐mediated silencing of TGF‐β R1 and TGF‐β R2 genes on the proliferation and apoptosis of penile urethral epithelial cells in hypospadiac male rats
This study ultimately demonstrated that the silencing of TGF‐β R1 and TGF‐β R2 genes could promote cell proliferation and inhibit apoptosis of penile UECs in hypospadiac male rats. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 4, 2017 Category: Biochemistry Authors: Chao Wang, Yan ‐Yan Qiao Tags: Article Source Type: research

SiRNA ‐mediated down‐regulation of CLIC4 gene inhibits cell proliferation and accelerates cell apoptosis of mouse liver cancer Hca‐F and Hca‐P cells
This study explored the effects involved in silencing CLIC4 on apoptosis and proliferation of mouse liver cancer Hca‐F and Hca‐P cells. A CLIC4‐target small interfering RNA (siRNA) was designed to compound into two individual complementary oligonucleotide chains. A process of annealing and connection to a pSilencer vector was followed by transfection with Hca‐F and Hca‐P cells. Quantitative real‐time polymerase chain reaction and western blotting techniques were used to determine CLIC4 mRNA and protein expressions. CCK8 assay and flow cytometry were employed for analysis of the survival and apoptosis rate as we...
Source: Journal of Cellular Biochemistry - June 21, 2017 Category: Biochemistry Authors: Qiu ‐Yun Yu, Xin‐Feng Zhou, Qing Xia, Jia Shen, Jia Yan, Jiu‐Ting Zhu, Xiang Li, Ming Shu Tags: Article Source Type: research

Hypoxia ‐induced microRNA‐26b inhibition contributes to hypoxic pulmonary hypertension via CTGF
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 17, 2017 Category: Biochemistry Authors: Sijing Zhou, Li Sun, Chao Cao, Peipei Wu, Min Li, Gengyun Sun, Guanghe Fei, Xing Ding, Ran Wang Tags: Article Source Type: research

NGAL gene silencing inhibits proliferation and promotes apoptosis of human gastric cancer cells: an in vivo and in vitro study
This study aims to explore effects of neutrophil gelatinase‐associated lipocalin (NGAL) gene silencing on the proliferation and apoptosis of human gastric cancer MGC‐803 and SGC‐7901 cells. NGAL‐siRNA was designed, synthesized and randomly divided into NGAL‐siRNA and control‐siRNA groups. Gastric cancer cells MGC‐803 and SGC‐7901 were grouped into blank, NGAL‐OE, and control‐OE groups. Expression of NGAL and apoptosis‐related proteins were detected by qRT‐PCR and Western blotting. Cell cycle and apoptosis were tested by flow cytometry, and cell proliferation by water soluble tetrazolium‐1 (WST‐1...
Source: Journal of Cellular Biochemistry - December 11, 2017 Category: Biochemistry Authors: Ming ‐Yang Han, Jie‐Wei Nie, Yuan‐Yuan Li, Yuan‐Zeng Zhu, Gang Wu Tags: Article Source Type: research

Upregulation of SRF Is Associated with Hypoxic Pulmonary Hypertension by Promoting Viability of Smooth Muscle Cells via Increasing Expression of Bcl ‐2
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - February 7, 2017 Category: Biochemistry Authors: Xing Ding, Sijing Zhou, Min Li, Chao Cao, Peipei Wu, Li Sun, Guanghe Fei, Ran Wang Tags: Article Source Type: research

mTORC1 signaling is essential for neurofibromatosis type I gene modulated osteogenic differentiation of BMSCs
In conclusion, NF1 modulates osteogenic differentiation and cell proliferation of human BMSCs and mTORC1 signaling is essential for this process. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - December 20, 2017 Category: Biochemistry Authors: YiQiang Li, JingChun Li, QingHe Zhou, Yuanzhong Liu, WeiDong Chen, HongWen Xu Tags: Article Source Type: research

Gremlin Aggravates Hyperglycemia‐Induced Podocyte Injury by a TGFβ/Smad Dependent Signaling Pathway
In conclusion, gremlin was clearly elevated in high glucose cultured mouse podocytes, and likely employed endogenous canonical TGFβ1/Smad signaling to induce podocyte injury. Knockdown gremlin1 by siRNA may be clinically useful in the attenuation of podocyte injury. J. Cell. Biochem. © 2013 Wiley Periodicals, Inc.
Source: Journal of Cellular Biochemistry - March 31, 2013 Category: Biochemistry Authors: Guiying Li, Ying Li, Shuxia Liu, Yonghong Shi, Yanqing Chi, Guijing Liu, Tieying Shan Tags: Article Source Type: research

An ATF4‐Signal‐Modulating Machine Other Than GADD34 Acts in ATF4‐to‐CHOP Signaling to Block CHOP Expression in ER‐Stress‐Related Autophagy
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - March 3, 2015 Category: Biochemistry Authors: Noboru Iwasaki, Yoshiki Sugiyama, Shuichi Miyazaki, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsuo Tags: Article Source Type: research

Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain‐Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - November 18, 2015 Category: Biochemistry Authors: Kei Kashiwai, Mikihito Kajiya, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara Tags: Article Source Type: research

Role of Small Interfering RNA Silencing Protein Kinase C ‐α Gene on the Occurrence of Ultrafiltration Failure in Peritoneal Dialysis Rats
This study aims to explore the effect of PKC‐α gene silencing on the occurrence of ultrafiltration failure (UFF) in peritoneal dialysis (PD) rats. Forty‐eight male SD rats were collected to establish 5/6 renal resection uremic and uremic PD rats models. Rats were assigned into control, sham operation, uremia, PD‐2 W (peritoneal dialysis for 2 weeks), PD‐4 W (peritoneal dialysis for 4 weeks), negative control (NC) (peritoneal dialysis for 4 weeks, and injected 0.1 mg/kg blank plasmid into abdominal cavity) and PKC‐α siRNA (peritoneal dialysis for 4 weeks, and injected 0.1 mg/kg PKC‐α siRNA into abdomi...
Source: Journal of Cellular Biochemistry - May 9, 2017 Category: Biochemistry Authors: Zhi ‐Wei Sun, Jian Wang, Min Weng, Jian‐Zhong Tang, Jun‐Feng Wang, Jian Xu, Ling Lin, Hong‐Ling Yuan Tags: Article Source Type: research

Activation of the Nrf2 ‐ARE Signaling Pathway Prevents Hyperphosphatemia‐Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells
This study investigates the effect of nuclear factor erythroid 2‐related factor 2‐antioxidant response element (Nrf2‐ARE) signaling pathway in vascular calcification (VC) via inducing Autophagy in renal vascular smooth muscle cells (VSMCs). VSMCs were assigned into six experimental groups: the normal control, high phosphorus, si‐negative control (si‐NC), Nrf2‐siRNA, over‐expressed Nrf2 and negative control (NC) groups. RT‐PCR was applied to detect the mRNA expressions of the desired Nrf2‐ARE signaling pathway‐related genes (Nrf2, NQO‐1, HO‐1, γ‐GCS). The protein products of these genes: apoptosis...
Source: Journal of Cellular Biochemistry - May 17, 2017 Category: Biochemistry Authors: Li Yao, Jian Wang, Bin ‐Yao Tian, Tian‐Hua Xu, Zi‐Tong Sheng Tags: Resaearch Article Source Type: research

Effects of S100A12 Gene Silencing on Serum Levels of Anti ‐Inflammatory/Pro‐Inflammatory Cytokines in Septic Rats through the ERK Signaling Pathway
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 3, 2018 Category: Biochemistry Authors: Xin Wen, Xin ‐Rui Han, Yong‐Jian Wang, Shao‐Hua Fan, Zi‐Feng Zhang, Dong‐Mei Wu, Jun Lu, Yuan‐Lin Zheng Tags: Article Source Type: research

Inhibition of apolipoprotein A‐I gene expression by tumor necrosis factor alpha in HepG2 cells: Requirement for c‐jun
Abstract Tumor necrosis factor alpha (TNF α) signals in part through the mitogen activated protein (MAP) kinase c‐jun‐N‐terminal kinase (JNK). Activation of JNK has been shown to promote insulin resistance and dyslipidemia, including reductions in plasma high‐density lipoprotein (HDL) and apolipoprotein A‐I (apo A‐I). To examine how TNF α‐mediated JNK activation inhibits hepatic apo A‐I production, the effects of c‐jun activation on apo A‐I gene expression were examined in HepG2 cells. Apo A‐I gene expression and promoter activity were measured by Northern and Western blotting and transient transfec...
Source: Journal of Cellular Biochemistry - August 22, 2013 Category: Biochemistry Authors: Shant Parseghian, Luisa M. Onstead‐Haas, Norman C.W. Wong, Arshag D. Mooradian, Michael J. Haas Tags: Article Source Type: research

Inhibition of Apolipoprotein A‐I Expression by TNF‐Alpha in HepG2 Cells: Requirement for c‐jun
ABSTRACT Tumor necrosis factor alpha (TNF α) signals in part through the mitogen activated protein (MAP) kinase c‐jun‐N‐terminal kinase (JNK). Activation of JNK has been shown to promote insulin resistance and dyslipidemia, including reductions in plasma high‐density lipoprotein (HDL) and apolipoprotein A‐I (apo A‐I). To examine how TNF α‐mediated JNK activation inhibits hepatic apo A‐I production, the effects of c‐jun activation on apo A‐I gene expression were examined in HepG2 cells. Apo A‐I gene expression and promoter activity were measured by Northern and Western blotting and transient transfec...
Source: Journal of Cellular Biochemistry - December 13, 2013 Category: Biochemistry Authors: Shant Parseghian, Luisa M. Onstead‐Haas, Norman C.W. Wong, Arshag D. Mooradian, Michael J. Haas Tags: Article Source Type: research

MicroRNA ‐329 inhibits cell proliferation and tumor growth while facilitates apoptosis via negative regulation of KDM1A in gastric cancer
Conclusion: We conclude that miRNA‐329 functions as a tumor suppressor in GC, which could be achieved via transcriptional suppression of KDM1A. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - November 11, 2017 Category: Biochemistry Authors: Lisheng Cai, Qiuxian Chen, Shunyong Fang, Mingqiao Lian, Mingzhi Cai Tags: Article Source Type: research