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Source: Journal of Cellular Biochemistry

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Total 134 results found since Jan 2013.

Role of JAK2–STAT3 in TLR2‐mediated tissue factor expression
This study investigated the mechanism regulating TF expression in macrophages using Pam3CSK4, a TLR2 ligand. Pam3CSK4 induced TF expression in two types of macrophages (Raw264.7 and BMDM), but not in TLR2 KO mice derived BMDM. Pam3CSK4 induced TF expression was inhibited by pretreatment with pan‐JAK inhibitor or JAK2 inhibitor AG490. JAK2 knock‐down by siRNA inhibited Pam3CSK4 induced TF expression. Pam3CSK4 stimulated STAT3 phosphorylation (S727), while STAT3 knock‐down by siRNA reduced Pam3CSK4 induced TF expression. These results suggest that Pam3CSK4 induced TF expression is regulated by the JAK2–STAT3 signalin...
Source: Journal of Cellular Biochemistry - April 16, 2013 Category: Biochemistry Authors: Dae‐Weon Park, Ji Hyo Lyu, Jin‐Sik Kim, Haemin Chin, Yoe‐Sik Bae, Suk‐Hwan Baek Tags: Article Source Type: research

Knockdown of PU.1 as lncRNA inhibits adipogenesis through enhancing PU.1 1 mRNA translation
Abstract PU.1 is an Ets family transcription factor involved in the myelo‐lymphoid differentiation. We have previously demonstrated that PU.1 is also expressed in the adipocyte lineage. However, the expression levels of PU.1 mRNA and protein in preadipocytes do not match the levels in mature adipocytes. PU.1 mRNA level is higher in preadipocytes, whereas its protein is expressed in the adipocytes but not in the preadipocytes. The underlying mechanism remains elusive. Here, we find that miR‐155 knockdown or overexpression has no effect on the levels of PU.1 mRNA and protein in preadipocytes or adipocytes. MiR‐155 regu...
Source: Journal of Cellular Biochemistry - June 7, 2013 Category: Biochemistry Authors: Wei‐Jun Pang, Li‐Gen Lin, Yan Xiong, Ning Wei, Yu Wang, Qing‐Wu Shen, Gong‐She Yang Tags: Article Source Type: research

Knockdown of PU.1 AS lncRNA inhibits adipogenesis through enhancing PU.1 mRNA translation
ABSTRACT PU.1 is an Ets family transcription factor involved in the myelo‐lymphoid differentiation. We have previously demonstrated that PU.1 is also expressed in the adipocyte lineage. However, the expression levels of PU.1 mRNA and protein in preadipocytes do not match the levels in mature adipocytes. PU.1 mRNA level is higher in preadipocytes, whereas its protein is expressed in the adipocytes but not in the preadipocytes. The underlying mechanism remains elusive. Here, we find that miR‐155 knockdown or overexpression has no effect on the levels of PU.1 mRNA and protein in preadipocytes or adipocytes. MiR‐155 regu...
Source: Journal of Cellular Biochemistry - September 12, 2013 Category: Biochemistry Authors: Wei‐Jun Pang, Li‐Gen Lin, Yan Xiong, Ning Wei, Yu Wang, Qing‐Wu Shen, Gong‐She Yang Tags: Article Source Type: research

Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL‐60 cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 5, 2015 Category: Biochemistry Authors: Suresh Kumar, Santosh Kumar Guru, Anup Singh Pathania, Sudhakar Manda, Ajay Kumar, Sandip B Bharate, Ram A Vishwakarma, Fayaz Malik, Shashi Bhushan Tags: Article Source Type: research

HIF‐2 inhibition supresses inflammatory responses and osteoclastic differentiation in human periodontal ligament cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 7, 2015 Category: Biochemistry Authors: Won‐Jung Bae, Mee‐Ran Shin, Soo‐Kyung Kang, Zhang Jun, Jun‐Yeol Kim, Sang‐Cheon Lee, Eun‐Cheol Kim Tags: Article Source Type: research

Increased SPHK2 transcription of human colon cancer cells in serum‐depleted culture: the involvement of CREB transcription factor
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Source: Journal of Cellular Biochemistry - March 24, 2015 Category: Biochemistry Authors: Naoki Mizutani, Yukari Omori, Koji Tanaka, Hiromi Ito, Akira Takagi, Tetsuhito Kojima, Masahiro Nakatochi, Hideo Ogiso, Yoshiyuki Kawamoto, Mitsuhiro Nakamura, Motoshi Suzuki, Mamoru Kyogashima, Keiko Tamiya‐Koizumi, Yoshinori Nozawa, Takashi Murate Tags: Article Source Type: research

Cycloartenyl Ferulate Inhibits Paraquat‐Induced Apoptosis in HK‐2 Cells with the Involvement of ABCC1
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Source: Journal of Cellular Biochemistry - September 12, 2015 Category: Biochemistry Authors: Guang‐Liang Hong, Jia‐Ming Liu, Guang‐Ju Zhao, Jia‐Ping Tan, Bin Wu, Meng‐Fang Li, Guang Liang, Qiao‐Meng Qiu, Zhong‐Qiu Lu Tags: Article Source Type: research

Foxc1 Expression in Early Osteogenic Differentiation Is Regulated by BMP4‐SMAD Activity
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Source: Journal of Cellular Biochemistry - December 15, 2015 Category: Biochemistry Authors: Alexander Hopkins, Freda Mirzayans, Fred Berry Tags: Article Source Type: research

Inhibition of Inositol 1, 4, 5 ‐trisphosphate Receptor Induce Breast Cancer Cell Death through Deregulated Autophagy and Cellular Bioenergetics
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Source: Journal of Cellular Biochemistry - January 19, 2017 Category: Biochemistry Authors: Aru Singh, Megha Chagtoo, Swasti Tiwari, Nelson George, Bandana Chakravarti, Sajid Khan, Sripada Lakshmi, Madan M Godbole Tags: Article Source Type: research

Angiopoietin ‐2 Enhances Osteogenic Differentiation of Bone Marrow Stem Cells
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Source: Journal of Cellular Biochemistry - February 17, 2017 Category: Biochemistry Authors: Mi ‐Lan Kang, Eun‐Ah Kim, Se‐Young Jeong, Gun‐Il Im Tags: Article Source Type: research

Lycopene protects keratinocytes against UVB radiation ‐induced carcinogenesis via negative regulation of FOXO3a through the mTORC2/AKT signaling pathway
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Source: Journal of Cellular Biochemistry - June 6, 2017 Category: Biochemistry Authors: Ping Chen, Shina Xu, Jinlong Qu Tags: Article Source Type: research

DJ ‐1 alleviates angiotensin II‐induced endothelial progenitor cell damage by activating the PPARγ/HO‐1 pathway
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Source: Journal of Cellular Biochemistry - June 10, 2017 Category: Biochemistry Authors: Tao Han, Meihan Liu, Songbai Yang Tags: Article Source Type: research

Effect of TET1 regulating MGMT on chemotherapy resistance of oral squamous cell carcinoma stem cells
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Source: Journal of Cellular Biochemistry - June 23, 2017 Category: Biochemistry Authors: Wei Wang, Xin Li, Fan Wang, Xiang ‐Yu Sun Tags: Article Source Type: research

Long noncoding RNA BDNF ‐AS inversely regulated BDNF and modulated high‐glucose induced apoptosis in human retinal pigment epithelial cells
Conclusion: Our results suggest that BDNF‐AS, through inverse regulation of BDNF, might play a critical role in the process of DGI apoptosis in diabetic retinopathy. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 28, 2017 Category: Biochemistry Authors: Yanyan Li, Feng Xu, Hanyan Xiao, Feng Han Tags: Article Source Type: research

Advanced glycation end ‐products and Porphyromonas gingivalis lipopolysaccharide increase calprotectin expression in human gingival epithelial cells
This study aimed at investigating the effects of AGE and Porphyromonas gingivalis lipopolysaccharide (PgLPS) on calprotectin expression in the human gingival epithelial cell line OBA‐9. AGE and PgLPS increased the expression of S100A8 and S100A9 mRNAs, and AGE + PgLPS co‐stimulation amplified their expression in OBA‐9 cells. A higher concentration of calprotectin in cell lysates was also induced by stimulation with AGE and/or PgLPS. S100A8 was mainly translocated from the nucleus to the cytoplasm by AGE stimulation, while cytoplasmic localization of S100A9 was not altered following stimulation with AGE and/or PgL...
Source: Journal of Cellular Biochemistry - August 3, 2017 Category: Biochemistry Authors: Yuka Hiroshima, Eijiro Sakamoto, Kaya Yoshida, Kaori Abe, Koji Naruishi, Takenori Yamamoto, Yasuo Shinohara, Jun ‐ichi Kido, Carolyn L. Geczy Tags: Article Source Type: research