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Propofol inhibits proliferation and migration of glioma cells by up-regulating lncRNA GAS5
Toxicol In Vitro. 2022 Jan 24:105321. doi: 10.1016/j.tiv.2022.105321. Online ahead of print.ABSTRACTPropofol has been documented to exhibit anti-tumor effects in cancers. However, the underlying mechanisms of its inhibition remain unclear. We conducted this study to investigate the effect of propofol on lncRNA GAS5 in glioma cells, and to probe the role of GAS5 in the anti-tumor effects of propofol. Human glioma cell line U251 were treated with propofol. Cell proliferation, migration, invasion, cell cycle and apoptosis were evaluated, and the expression of GAS5 was measured. After that, we knockdown the expression of GAS5 ...
Source: Toxicology in Vitro - January 27, 2022 Category: Toxicology Authors: Yan Cheng Lina Zheng Haiyun Wang Chenyi Yang Weiwei Zhang Source Type: research

Propofol Affects Non-Small-Cell Lung Cancer Cell Biology By Regulating the miR-21/PTEN/AKT Pathway In Vitro and In Vivo.
CONCLUSIONS: Our study indicated that propofol inhibited A549 cell growth, accelerated apoptosis via the miR-21/PTEN/AKT pathway in vitro, suppressed NSCLC tumor cell growth, and promoted apoptosis in vivo. Our findings provide new implications for propofol in cancer therapy and indicate that propofol is extremely advantageous in surgical treatment. PMID: 32925348 [PubMed - in process]
Source: Anesthesia and Analgesia - September 16, 2020 Category: Anesthesiology Authors: Zheng X, Dong L, Zhao S, Li Q, Liu D, Zhu X, Ge X, Li R, Wang G Tags: Anesth Analg Source Type: research

Propofol induces apoptosis of non-small cell lung cancer cells via ERK1/2-dependent upregulation of PUMA.
CONCLUSIONS: Propofol inhibits viability and induces apoptosis of A549 cells via an ERK1/2-dependent PUMA signaling. PMID: 30024623 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 20, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Propofol inhibits proliferation, migration, and invasion but promotes apoptosis by regulation of Sox4 in endometrial cancer cells.
This study aimed to explore the effects of propofol on EC in vitro and in vivo. Different concentrations of propofol were used to treat Ishikawa cells. Colony number, cell viability, cell cycle, apoptosis, migration, and invasion were analyzed by colony formation, MTT, flow cytometry, and Transwell assays. In addition, the pcDNA3.1-Sox4 and Sox4 siRNA plasmids were transfected into Ishikawa cells to explore the relationship between propofol and Sox4 in EC cell proliferation. Tumor weight in vivo was measured by xenograft tumor model assay. Protein levels of cell cycle-related factors, apoptosis-related factors, matrix meta...
Source: Braz J Med Biol Res - March 1, 2018 Category: Research Authors: Du Q, Liu J, Zhang X, Zhang X, Zhu H, Wei M, Wang S Tags: Braz J Med Biol Res Source Type: research

Propofol inhibits invasion and growth of ovarian cancer cells via regulating miR-9/NF- κB signal.
Propofol inhibits invasion and growth of ovarian cancer cells via regulating miR-9/NF-κB signal. Braz J Med Biol Res. 2016 Dec 12;49(12):e5717 Authors: Huang X, Teng Y, Yang H, Ma J Abstract Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. A previous study has found that propofol can inhibit invasion and induce apoptosis of ovarian cancer cells. However, the underlying mechanisms are not known. miR-9 has been reported to be little expressed in ovarian cancer cells, which has been related to a poor prognosis in patients with ovarian cancer. Studie...
Source: Brazilian Journal of Medical and Biological Research - December 17, 2016 Category: Research Tags: Braz J Med Biol Res Source Type: research

Propofol inhibits growth and invasion of pancreatic cancer cells through regulation of the miR-21/Slug signaling pathway.
CONCLUSIONS: Propofol can effectively inhibit invasion and induce apoptosis of PANC-1 cells by regulating miR-21/Slug signals. PMID: 27829997 [PubMed - in process]
Source: American Journal of Translational Research - November 12, 2016 Category: Research Tags: Am J Transl Res Source Type: research