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Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
Biochem Biophys Res Commun. 2022 Aug 31;628:110-115. doi: 10.1016/j.bbrc.2022.08.082. Online ahead of print.ABSTRACTColorectal cancer is a significant cause of morbidity and represents a serious public health issue in many countries. The development of a breakthrough preventive method for colorectal cancer is urgently needed. Aspirin has recently been attracting attention as a cancer preventive drug, and its inhibitory effects on the development of various cancers have been reported in several large prospective studies. However, the underlying molecular mechanisms have not yet been elucidated in detail. In the present stud...
Source: Biochemical and Biophysical Research communications - September 9, 2022 Category: Biochemistry Authors: Ayaka Imai Mano Horinaka Yuichi Aono Yosuke Iizumi Hideki Takakura Hisako Ono Shusuke Yasuda Keiko Taniguchi Emi Nishimoto Hideki Ishikawa Michihiro Mutoh Toshiyuki Sakai Source Type: research

Aspirin-induced long non-coding RNA suppresses colon cancer growth
CONCLUSIONS: lncRNA NEAT1 and LOC152578 are involved in the inhibition of tumor cell growth and metastasis by aspirin. The results of these analyses will help us further understand the mechanism of action of aspirin and the roles of lncRNAs in the prevention and treatment of colon cancer.PMID:35116527 | PMC:PMC8798653 | DOI:10.21037/tcr-20-2248
Source: Cancer Control - February 4, 2022 Category: Cancer & Oncology Authors: Mingwei Chen Lili Wu Huajie Zhan Tonghua Liu Yan He Source Type: research

PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research