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The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice
In conclusion, this research demonstrated that Palmatine attenuated depressive like behavior by modulating microglia polarization via PDE4B/KLF4 signaling.PMID:35917005 | DOI:10.1007/s11064-022-03672-3
Source: Neurochemical Research - August 2, 2022 Category: Neuroscience Authors: Lei Wang Min Li Cuiping Zhu Aiping Qin Jinchun Wang Xianni Wei Source Type: research

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non –Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway
This study mainly focused on the discovery of the molecular basis of the inhibitory effect of fluoxetine in lung cancer. The specific anti-proliferation effect and autophagy induced by fluoxetine on lung cancer cell were shown in CCK8 and immunofluorescence. The RNA sequence hinted that the endoplasmic reticulum (ER) stress-related protein and mTOR pathway were enriched after fluoxetine treatment. Western blot results revealed that the ER stress pathway was activated by fluoxetine, including PERK, ATF4, and CHOP, while the AKT/mTOR pathway was inhibited. In addition, the transfection of ATF4 siRNA further discovered that E...
Source: Frontiers in Pharmacology - May 10, 2022 Category: Drugs & Pharmacology Source Type: research

Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior
AbstractAging induces cellular and molecular changes including gene expression alteration in the brain, which might be associated with aging-induced decrease in stress coping ability. In the present study, we investigate how aging changes the ability to cope with stress and increases sensitivity to stress. Aged mice show decreased expression of SUV39H1 histone methyltransferase and increased expression of Mkp-1 in the hippocampus. The siRNA-mediated knockdown of SUV39H1 increases Mkp-1 expression and suppresses p-CREB and Bdnf expression in HT22 cells and in the hippocampus of mice. Chromatin immunoprecipitation assays ind...
Source: Molecular Neurobiology - September 18, 2021 Category: Neurology Source Type: research

Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF- κB.
Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB. Brain Res Bull. 2020 Jan 08;: Authors: Chao B, Huang S, Pan J, Zhang Y, Wang Y Abstract Saikosaponin d (SSd) is a traditional Chinese medicine that has been widely used in depression treatment. Given the lack of studies demonstrating the underlying mechanism of action of SSd in depression, the presented study was conducted with aims of investigating the effect of SSd on rats with depression-like behaviors induced by un...
Source: Brain Research Bulletin - January 7, 2020 Category: Neurology Authors: Chao B, Huang S, Pan J, Zhang Y, Wang Y Tags: Brain Res Bull Source Type: research

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression.
We examined the ability of the neuropeptide Galanin(1-15) [GAL(1-15)] to modulate the behavioral effects of FLX in the forced swimming test (FST) and studied feasible molecular mechanisms. The data show that GAL(1-15) enhances the antidepressant-like effects induced by FLX in the FST, and we demonstrate the involvement of GALR1/GALR2 heteroreceptor complex in the GAL(1-15)-mediated effect using in vivo rat models for siRNA GALR1 or GALR2 knockdown. Importantly, 5-HT1A receptors (5HT1AR) also participate in the GAL(1-15)/FLX interactions since the 5HT1AR antagonist WAY100635 blocked the behavioral effects in the FST induced...
Source: Neuropharmacology - March 9, 2017 Category: Drugs & Pharmacology Authors: Flores-Burgess A, Millón C, Gago B, Narváez M, Borroto-Escuela DO, Mengod G, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z Tags: Neuropharmacology Source Type: research