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Drug: Estradiol
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Total 353 results found since Jan 2013.
Protective effect of estrogen receptors (ER α/β) against the intervertebral disc degeneration involves activating CCN5 via the promoter
CONCLUSIONS: Upregulation of ERα and ERβ protects the NP cell degeneration during IDD through the activation of CCN5 by binding to its promoter.PMID:33660790 | DOI:10.26355/eurrev_202102_25075
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: M-X Song X-X Ma C Wang Y Wang C Sun D-R Xu K Zhu G-H Li H Zhao C Zhang Source Type: research
Bmal1 promotes prostaglandin E2 synthesis by up-regulating Ptgs2 transcription in response to increasing estradiol levels in day 4 pregnant mice.
Abstract
Prostaglandin G/H synthase 2 (Ptgs2) is a rate-limiting enzyme in prostaglandin synthesis. The present study assessed the role of the uterine circadian clock on Ptgs2 transcription in response to steroid hormones during early pregnancy. We demonstrated that the core clock genes (Bmal1, Per2, Nr1d1, and Dbp), Vegf, and Ptgs2, and their encoded proteins, have rhythmic expression in the mouse uterus from days 3.5 to 4.5 (D3.5-4.5) of pregnancy. Progesterone (P4) treatment of cultured uterus endometrial stromal cells (UESCs) isolated from mPer2Luciferase reporter gene knock-in mice on D4 induced a phase shift...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 8, 2021 Category: Physiology Authors: Zhao L, Yang L, Zhang J, Xiao Y, Wu M, Ma T, Wang X, Zhang L, Jiang H, Chao HW, Wang A, Jin Y, Chen H Tags: Am J Physiol Endocrinol Metab Source Type: research
Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion.PMID:33334789
Source: Annals of Clinical and Laboratory Science - December 18, 2020 Category: Laboratory Medicine Authors: Zhengming Yang Jianjun Qian Wei Yu Minfei Yang Bin Liu Huimin Tao Source Type: research
Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells.
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion.
PMID: 33334789 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - November 1, 2020 Category: Laboratory Medicine Authors: Yang Z, Qian J, Yu W, Yang M, Liu B, Tao H Tags: Ann Clin Lab Sci Source Type: research
Modulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells.
CONCLUSION: Our findings suggest that estrogen induces BPH possibly by promoting AQP5 expression. Hence, AQP5 might be a novel target for modulating EMT in prostate epithelial cells.
PMID: 33031138 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - October 7, 2020 Category: General Medicine Authors: Fan Y, Song TR, Wei Q, Yang L, Lin T, Feng XB, Wang XD, Huang ZL, Feng SJ Tags: Chin Med J (Engl) Source Type: research
