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Total 353 results found since Jan 2013.
Matrix Metalloproteinases in Human Decidualized Endometrial Stromal Cells
Curr Issues Mol Biol. 2021 Nov 26;43(3):2111-2123. doi: 10.3390/cimb43030146.ABSTRACTCyclic changes, such as growth, decidualization, shedding, and regeneration, in the human endometrium are regulated by the reciprocal action of female hormones, such as estradiol (E2), and progesterone (P4). Matrix metalloproteases (MMPs) and tissue inhibitors of MMPs (TIMPs) control the invasion of extravillous trophoblast cells after implantation. Several MMPs and TIMPs function in the decidua and endometrial stromal cells (ESCs). Here, we aimed to systematically investigate the changes in MMPs and TIMPs associated with ESC decidualizati...
Source: Current Issues in Molecular Biology - December 23, 2021 Category: Molecular Biology Authors: Yoji Hisamatsu Hiromi Murata Hiroaki Tsubokura Yoshiko Hashimoto Masaaki Kitada Susumu Tanaka Hidetaka Okada Source Type: research
X-linked histone H3K27 demethylase Kdm6a regulates sexually dimorphic differentiation of hypothalamic neurons
Cell Mol Life Sci. 2021 Oct 11. doi: 10.1007/s00018-021-03945-0. Online ahead of print.ABSTRACTSeveral X-linked genes are involved in neuronal differentiation and may contribute to the generation of sex dimorphisms in the brain. Previous results showed that XX hypothalamic neurons grow faster, have longer axons, and exhibit higher expression of the neuritogenic gene neurogenin 3 (Ngn3) than XY before perinatal masculinization. Here we evaluated the participation of candidate X-linked genes in the development of these sex differences, focusing mainly on Kdm6a, a gene encoding for an H3K27 demethylase with functions controll...
Source: Cellular and Molecular Life Sciences : CMLS - October 11, 2021 Category: Cytology Authors: Lucas E Cabrera Zapata Carla D Cisternas Camila Sosa Luis Miguel Garcia-Segura Maria Angeles Arevalo Mar ía Julia Cambiasso Source Type: research
The multifaceted biology of PCSK9
This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating LDL-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain (CHRD), its bind...
Source: Endocrine Reviews - October 9, 2021 Category: Endocrinology Authors: Nabil G Seidah Annik Prat Source Type: research
17 β-Estradiol activates Cl < sup > - < /sup > channels via the estrogen receptor α pathway in human thyroid cells
In this study, the effects of estrogen on chloride channel activities in human thyroid Nthy-ori3-1 cells were therefore investigated using the whole cell patch-clamp technique. The results showed that the extracellular application of 17β-estradiol (E2) activated Cl- currents, which reversed at a potential close to Cl- equilibrium potential and showed remarkable outward rectification and an anion permeability of I- > Br- > Cl- > gluconate. The Cl- currents were inhibited by the chloride channel blockers, NPPB and tamoxifen. Quantitative Real-time PCR results demonstrated that ClC-3 expression was highest in ClC fa...
Source: Channels - August 20, 2021 Category: Molecular Biology Authors: Meisheng Yu Yuan Wei Yanfang Zheng Lili Yang Long Meng Jiawei Lin Peisheng Xu Sanaa Ahmed Nagi Abdu Mahdy Linyan Zhu Shuang Peng Lixin Chen Liwei Wang Source Type: research
