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1,25-Dihydroxyvitamin D < sub > 3 < /sub > Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4
Conclusion: 1,25D3 causes ectodomain shedding of TLR4 and thereby decreases the responsiveness of cells to LPS. ADAM10, activated by extracellular Ca2+ influx, was implicated in the ectodomain cleavage of TLR4.Cell Physiol Biochem 2017;41:2104 –2116
Source: Cellular Physiology and Biochemistry - April 20, 2017 Category: Cytology Source Type: research

Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
In this study, we examined the potencies of other vitamin D3 and D2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs. 25-Hydroxyvitamin D3 (25D3), a precursor of 1,25D3, and elocalcitol, an analog of 1,25D3, caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D2 (1,25D2) and paricalcitol, a derivative of 1,25D2, did not. Both 25D3 and elocalcitol rapidly induced extracellular Ca2+ influx and markedly increased intracellular Ca2+, while 1,25D2 and paricalcitol caused only small increases in intracellular Ca2+. 25D3- and elocalcitol-induced TNFR1 ectodomain sheddings were abolished ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 30, 2015 Category: Biochemistry Source Type: research

Title: Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
In this study, we examined the potencies of other vitamin D3 and D2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs. 25-Hydroxyvitamin D3 (25D3), a precursor of 1,25D3, and elocalcitol, an analog of 1,25D3, caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D2 (1,25D2) and paricalcitol, a derivative of 1,25D2, did not. Both 25D3 and elocalcitol rapidly induced extracellular Ca2+ influx and markedly increased intracellular Ca2+, while 1,25D2 and paricalcitol caused only small increases in intracellular Ca2+. 25D3- and elocalcitol-induced TNFR1 ectodomain sheddings were abolished ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 16, 2015 Category: Biochemistry Source Type: research

Role of the parathyroid hormone type 1 receptor (PTH1R) as a mechanosensor in osteocyte survival
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - December 1, 2014 Category: Orthopaedics Authors: Marta Maycas, Juan A. Ardura, Luis Fernández de Castro, Beatriz Bravo, Arancha R. Gortázar, Pedro Esbrit Tags: Original Article Source Type: research