Filtered By:
Drug: Verapamil

This page shows you your search results in order of date.

Order by Relevance | Date

Total 20 results found since Jan 2013.

Thyroid hormone transporters in a human placental cell model
Conclusions Using pharmacological inhibitors, we show that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears independent of known TH transporters, suggesting the presence of, currently unknown, alternative transporter(s).PMID:35699060 | DOI:10.1089/thy.2021.0503
Source: Thyroid : official journal of the American Thyroid Association - June 14, 2022 Category: Endocrinology Authors: Zhongli Chen A S Elise van der Sman Stefan Groeneweg Linda J de Rooij W Edward Visser Robin P Peeters Marcel E Meima Source Type: research

Isoproterenol-induced hypertrophy of neonatal cardiac myocytes and H9c2 cell is dependent on TRPC3-regulated CaV1.2 expression.
In this study, we aimed to examine the relationship between these two proteins and characterize their role in neonatal cardiomyocytes. We measured CaV1.2 expression in the hearts of wild-type (WT) and Trpc3-/- mice, and examined the effects of Trpc3 knockdown and overexpression in the rat cell line H9c2. We also compared the hypertrophic responses of neonatal cardiomyocytes cultured from Trpc3-/- mice to a representative hypertrophy-causing drug, isoproterenol (ISO), and measured the activity of nuclear factor of activated T cells 3 (NFAT3) in neonatal cardiomyocytes (NCMCs). We inhibited the L-type current with nifedipine...
Source: Cell Calcium - October 6, 2020 Category: Cytology Authors: Han JW, Kang C, Kim Y, Lee MG, Kim JY Tags: Cell Calcium Source Type: research

Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1-5).
Authors: Hasegawa N, Furugen A, Ono K, Koishikawa M, Miyazawa Y, Nishimura A, Umazume T, Narumi K, Kobayashi M, Iseki K Abstract Lamotrigine (LTG) is an important antiepileptic drug for the treatment of seizures in pregnant women with epilepsy. However, it is not known if the transport of LTG into placental cells occurs via a carrier-mediated pathway. The aim of this study was to investigate the uptake properties of LTG into placental cell lines (BeWo and JEG-3), and to determine the involvement of organic cation transporters (OCTs, SLC22A1-3) and organic cation/carnitine transporter (OCTNs, SLC22A4-5) in the uptak...
Source: Drug Metabolism and Pharmacokinetics - April 20, 2020 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
CONCLUSIONS Upregulation of UCHL1 enhanced the reversal effect of VER on chemo-resistance to ADM and promoted cell apoptosis. The underlying mechanism of the function of UCHL1 and the signaling pathway involved in its effect are to be investigated in our future research. PMID: 29627846 [PubMed - in process]
Source: Medical Science Monitor - April 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.
Authors: Mahbouli S, Der Vartanian A, Ortega S, Rougé S, Vasson MP, Rossary A Abstract NADPH oxidase (NOX) complexes (a family of seven isoforms) drive cellular ROS production in patho-logical processes such as cancer. NOX-driven ROS production is involved in cell mechanisms from signalling to oxidative stress. Leptin, an adipokine overexpressed in obese patients, has been investigated in studies on breast carcinogenesis, but its effects on oxidative stress remain largely unexplored, especially in breast cancer. The study used three human mammary epithelial cell models presenting different neoplastic status (healt...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia
Publication date: October 2017 Source:Redox Biology, Volume 13 Author(s): Saisudha Koka, Min Xia, Yang Chen, Owais M. Bhat, Xinxu Yuan, Krishna M. Boini, Pin-Lan Li The NLRP3 inflammasome has been reported to be activated by atherogenic factors, whereby endothelial injury and consequent atherosclerotic lesions are triggered in the arterial wall. However, the mechanisms activating and regulating NLRP3 inflammasomes remain poorly understood. The present study tested whether acid sphingomyelinase (ASM) and ceramide associated membrane raft (MR) signaling platforms contribute to the activation of NLRP3 inflammasomes and ather...
Source: Redox Biology - June 19, 2017 Category: Biology Source Type: research

1,25-Dihydroxyvitamin D < sub > 3 < /sub > Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4
Conclusion: 1,25D3 causes ectodomain shedding of TLR4 and thereby decreases the responsiveness of cells to LPS. ADAM10, activated by extracellular Ca2+ influx, was implicated in the ectodomain cleavage of TLR4.Cell Physiol Biochem 2017;41:2104 –2116
Source: Cellular Physiology and Biochemistry - April 20, 2017 Category: Cytology Source Type: research

Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation.
CONCLUSION: Oral administration of hesperidin effectively alleviates rat POI through inhibition of inflammatory responses and stimulation of Ca(2+)-dependent MLC phosphorylation. PMID: 27345626 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - June 26, 2016 Category: Drugs & Pharmacology Authors: Xiong YJ, Chu HW, Lin Y, Han F, Li YC, Wang AG, Wang FJ, Chen DP, Wang JY Tags: Acta Pharmacol Sin Source Type: research

Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
In this study, we examined the potencies of other vitamin D3 and D2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs. 25-Hydroxyvitamin D3 (25D3), a precursor of 1,25D3, and elocalcitol, an analog of 1,25D3, caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D2 (1,25D2) and paricalcitol, a derivative of 1,25D2, did not. Both 25D3 and elocalcitol rapidly induced extracellular Ca2+ influx and markedly increased intracellular Ca2+, while 1,25D2 and paricalcitol caused only small increases in intracellular Ca2+. 25D3- and elocalcitol-induced TNFR1 ectodomain sheddings were abolished ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 30, 2015 Category: Biochemistry Source Type: research

Title: Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
In this study, we examined the potencies of other vitamin D3 and D2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs. 25-Hydroxyvitamin D3 (25D3), a precursor of 1,25D3, and elocalcitol, an analog of 1,25D3, caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D2 (1,25D2) and paricalcitol, a derivative of 1,25D2, did not. Both 25D3 and elocalcitol rapidly induced extracellular Ca2+ influx and markedly increased intracellular Ca2+, while 1,25D2 and paricalcitol caused only small increases in intracellular Ca2+. 25D3- and elocalcitol-induced TNFR1 ectodomain sheddings were abolished ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 16, 2015 Category: Biochemistry Source Type: research

P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement
Conclusion: P-gp over-expression is a possible mechanism of acquired resistance to 17-DMAG in cells with ALK rearrangement.
Source: BMC Cancer - July 29, 2015 Category: Cancer & Oncology Authors: Hee KimKye LeeYoung KimYun ChoiJung-Eun LeeChang ChoiIn-Jeoung BaekJin RhoJae Lee Source Type: research

Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2.
Abstract Hesperetin, the aglycone of hesperidin, occurs naturally in citrus fruits. It exerts extensive pharmacological activities. However, hesperetin's poor solubility and low bioavailability limits its wide application. In order to overcome these limitations, recently a series of novel hesperitin derivatives containing Mannich base moieties were synthesized and the anti-inflammatory activity was evaluated, among which MTBH (8-methylene-tert-butylamine-3',5,7-trihydroxy-4'-methoxyflavanone) showed a significantly improved water solubility, and promising anti-inflammatory activity in vitro and in vivo compared wi...
Source: European Journal of Pharmaceutical Sciences - July 28, 2015 Category: Drugs & Pharmacology Authors: Shen C, Chen R, Qian Z, Meng X, Hu T, Li Y, Chen Z, Huang C, Hu C, Li J Tags: Eur J Pharm Sci Source Type: research

Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
Authors: Higuchi K, Kitamura A, Okura T, Deguchi Y Abstract Memantine is clinically used for the treatment of patients with Alzheimer's disease and is highly distributed to the brain. The aim of this study is to characterize memantine transport at the blood-brain barrier (BBB) using hCMEC/D3 cells, a human BBB model. The initial uptake velocity of memantine in hCMEC/D3 cells was concentration-dependent, and was reduced by metabolic inhibitors, but was independent of extracellular sodium ion and membrane potential. Intracellular alkalization and intracellular acidification markedly reduced and enhanced the uptake, r...
Source: Drug Metabolism and Pharmacokinetics - April 12, 2015 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells.
Abstract Chemotherapy is one of the most common therapeutic option for metastatic tumors and hematological malignancies. ABCB1-mediated multidrug resistance is the major obstacle for chemotherapy. Natural products with diversified structures are ideal source of ABCB1 modulators. Ganoderenic acid B, a lanostane-type triterpene isolated from Ganoderma lucidum, exhibited potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to doxorubicin, vincristine and paclitaxel. Similarly, ganoderenic acid B could also significantly reverse the resistance of ABCB1-overexpressing MCF-7/ADR cells to dox...
Source: International Journal of Oncology - March 12, 2015 Category: Cancer & Oncology Authors: Liu DL, Li YJ, Yang DH, Wang CR, Xu J, Yao N, Zhang XQ, Chen ZS, Ye WC, Zhang DM Tags: Int J Oncol Source Type: research