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Total 90 results found since Jan 2013.
Linc-ROR promotes invasion and metastasis of gastric cancer by activating epithelial-mesenchymal transition
CONCLUSION: Linc-ROR can regulate cell invasion and metastasis by activating the epithelial-mesenchymal transition process partially through Wnt/β-catenin signal pathway in the gastric cancer cells. Link-ROR may be an important molecule for the metastasis of gastric cancer.PMID:35900480 | DOI:10.4103/ijpm.ijpm_696_21
Source: Indian Journal of Pathology and Microbiology - July 28, 2022 Category: Pathology Authors: Mengyao Liu Mingkai Zhang Hongshan Yin Source Type: research
Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines
Eur J Pharmacol. 2022 Jun 21:175113. doi: 10.1016/j.ejphar.2022.175113. Online ahead of print.ABSTRACTWithaferin A (WFA), a withanolide, is isolated from plants of Withania somnifera (L.) Dual (Solanaceae), known as Indian ginseng, Indian winter cherry or Ashwagandha. It has been reported to exert multifaceted anti-neoplastic effects. Here, we analyzed the impact of WFA on apoptosis and autophagy activation in different human colorectal cancer cell lines. We observed that WFA exposure caused an increased aggregation of cells in the subG1 arrest in cell cycle, and increased the number of late apoptotic cells. WFA also induc...
Source: European Journal of Pharmacology - June 24, 2022 Category: Drugs & Pharmacology Authors: Young Yun Jung Jae-Young Um Arunachalam Chinnathambi Chandramohan Govindasamy Acharan S Narula Ojas A Namjoshi Bruce E Blough Gautam Sethi Kwang Seok Ahn Source Type: research
Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation
Infect Genet Evol. 2022 May 27:105310. doi: 10.1016/j.meegid.2022.105310. Online ahead of print.ABSTRACTNipah virus (NiV), a zoonotic virus, engenders severe infections with noticeable complications and deaths in humans and animals. Since its emergence, it is frightening that this virus has been causing regular outbreaks in various countries, particularly Bangladesh, India, and Malaysia. Unfortunately, no efficient vaccine or drug is available to combat this baneful virus. It employs the nucleocapsid protein in its genetic material encapsidation, which is a crucial for viral replication. The small interfering RNAs (siRNAs)...
Source: Infection, Genetics and Evolution - May 31, 2022 Category: Genetics & Stem Cells Authors: A M U B Mahfuz Md Arif Khan Emran Hossain Sajib Anamika Deb Shafi Mahmud Mahmudul Hasan Otun Saha Ariful Islam M Mizanur Rahaman Source Type: research
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains
Comput Biol Chem. 2022 Apr 29;98:107687. doi: 10.1016/j.compbiolchem.2022.107687. Online ahead of print.ABSTRACTSARS-CoV-2 is a highly transmissible and pathogenic coronavirus that first emerged in late 2019 and has since triggered a pandemic of acute respiratory disease named COVID-19 which poses a significant threat to all public health institutions in the absence of specific antiviral treatment. Since the outbreak began in March 2020, India has reported 4.77 lakh Coronavirus deaths, according to the World Health Organization (WHO). The innate RNA interference (RNAi) pathway, on the other hand, allows for the development...
Source: Computational Biology and Chemistry - May 10, 2022 Category: Bioinformatics Authors: Premnath Madanagopal Harshini Muthukumar Kothai Thiruvengadam Source Type: research
Discovering the role of FZD4 Gene in human cutaneous squamous cell carcinoma
Conclusion: The results indicated that FZD4 may play as a tumor suppressor gene in the pathogenesis of CSCC.
Source: Indian Journal of Dermatology - December 9, 2021 Category: Dermatology Authors: Ke Zhang Qun Lv Liming Li Mingjun Jiang Fang Fang Source Type: research
miR-143 is implicated in growth plate injury by targeting IHH in precartilaginous stem cells
Int J Med Sci. 2021 Mar 3;18(9):1999-2007. doi: 10.7150/ijms.46474. eCollection 2021.ABSTRACTPrecartilaginous stem cells (PCSCs) are able to initiate chondrocyte and bone development. The present study aimed to investigate the role of miR-143 and the underlying mechanisms involved in PCSC proliferation. In a rat growth plate injury model, tissue from the injury site was collected and the expression of miR-143 and its potential targets was determined. PCSCs were isolated from the rabbits' distal epiphyseal growth plate. Cell viability, DNA synthesis, and apoptosis were determined with MTT, BrdU, and flow cytometric analysis...
Source: International Journal of Medical Sciences - April 14, 2021 Category: Biomedical Science Authors: Fu-Yong Zhang Yun-Fang Zhen Zhi-Xiong Guo Jin Dai Lun-Qing Zhu Pei-Rong Liang Guang-Hao Su Wen-Yan Zhang Jian-Feng Fang Quan-Wen Yuan Feng Yao Ya Liu Yi Qiao Ya Zhang Wan-Liang Guo Yao Liu Xiao-Dong Wang Source Type: research
Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway
This study focused on the effects of TRPM7 on arthritic chondrocyte injury and its underlying mechanisms of action. Sodium nitroprusside (SNP)-induced rat primary chondrocyte apoptosis and rat adjuvant arthritis (AA) were used as in vitro and in vivo models, respectively. Blockage of TRPM7 with 2-APB or specific siRNA resulted in increased chondrocyte viability and reduced toxicity of SNP. Moreover, treatment with 2-APB enhanced the Bcl-2/Bax ratio and reduced cleaved PARP and IL-6, MMP-13 and ADAMTS-5 expression in SNP-treated chondrocytes. Activation of Indian Hedgehog with purmorphamine reversed the protective effects o...
Source: Frontiers in Pharmacology - April 13, 2021 Category: Drugs & Pharmacology Source Type: research
Strategic Design of Dicer Substrate siRNA to Mitigate the Resistance Mediated by ABCC1 in Doxorubicinresistant Breast Cancer
A. K. GATTA, R. CHANDRASHEKHAR, N. UDUPA, M. S. REDDY, S. MUTALIK AND V. R. JOSYULA*
Source: Indian Journal of Pharmaceutical Sciences - August 19, 2020 Category: Drugs & Pharmacology Source Type: research
Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.
This study explored the role IHH in the senescence of BMSC obtained from human samples and senescent mice. Isolated BMSC were transfected with IHH siRNA or incubated with exogenous IHH protein and the mechanisms of aging and differentiation investigated. Moreover, the interactions between IHH, and mammalian target of rapamycin (mTOR) and reactive oxygen species (ROS) were evaluated using the corresponding inhibitors and antioxidants. BMSC transfected with IHH siRNA showed characteristics of senescence-associated features including increased senescence-associated β-galactosidase activity (SA-β-gal), induction of cell cycl...
Source: Aging - March 31, 2020 Category: Biomedical Science Authors: Al-Azab M, Wang B, Elkhider A, Walana W, Li W, Yuan B, Ye Y, Tang Y, Almoiliqy M, Adlat S, Wei J, Zhang Y, Li X Tags: Aging (Albany NY) Source Type: research
