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MicroRNA ‐155 inhibition up‐regulates LEPR to inhibit osteoclast activation and bone resorption via activation of AMPK in alendronate‐treated osteoporotic mice
AbstractOsteoporosis is characterized by a progressive increase in bone fragility, leading to low bone mass and structural deterioration of bone tissue. MicroRNA ‐155 (miR‐155) is highly expressed in osteoporosis. Thus, the current study aimed to investigate the effect of miR‐155 on the inhibition of osteoclast activation and bone resorption by targeting leptin receptor (LEPR) through the adenosine monophosphate activated protein kinase (AMPK) pathway in alendronate‐treated osteoporotic mice. An osteoporosis mouse model was established to examine the bone tension and bone density and the expression of miR‐155 in ...
Source: IUBMB Life - July 17, 2019 Category: Research Authors: Zhongxuan Mao, Yihai Zhu, Weimin Hao, Chao Chu, Hongmin Su Tags: RESEARCH COMMUNICATION Source Type: research

Decrease of GSK3 β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model
AbstractNowadays, the cumulative intake of glucocorticoids has become the most common pathogenic factor for non-traumatic osteonecrosis of the femoral head (ONFH). Apoptosis of osteoblasts is considered as the main reason of ONFH at the molecular level. Glycogen synthase kinase 3 β (GSK3β) is an important regulator of cellular differentiation and apoptosis pathway, which can modulate the balance between osteoblasts and osteoclasts. Several studies have reported about its function in osteoporosis, but little is known about it in osteonecrosis. In our study, lipopolysacchari de and methylprednisolone were utilized to estab...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 31, 2019 Category: Research Source Type: research

Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP-pathway.
Authors: Li M, Zhang C, Li X, Lv Z, Chen Y, Zhao J Abstract Isoquercitrin is widely present in fruits, vegetables and medicinal herbs. As a natural phytoestrogen, isoquercitrin has been considered a possible osteoporosis prevention option to avoid the risk of hormone therapy. In this work, we studied the effects of isoquercitrin on the cell proliferation and osteogenic differentiation of osteoblasts and bone mesenchymal stem cells (BMSCs), as well as the molecular mechanism of isoquercitrin action. The cell proliferation of osteoblasts and BMSCs was promoted by isoquercitrin at low concentrations. High concentratio...
Source: Connective Tissue Research - June 4, 2018 Category: Research Tags: Connect Tissue Res Source Type: research

MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling.
In conclusion, miR-30a attenuated osteoclastogenesis via suppression of DC-STAMP-c-Fos-NFATc1 signaling pathway. On these grounds, this study may reveal a new promising target for the treatment of osteoporosis and other osteopenic disorders. PMID: 29312525 [PubMed]
Source: American Journal of Translational Research - January 11, 2018 Category: Research Tags: Am J Transl Res Source Type: research