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Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1084-3888The human urea transporter SLC14A1 (HUT11/UT-B) has been suggested as a marker for the adipogenic differentiation of bone cells with a relevance for bone diseases. We investigated the function of SLC14A1 in different cells models from bone environment. SLC14A1 expression and cytokine production was investigated in bone cells obtained from patients with osteoporosis. Gene and protein expression of SLC14A1 was studied during adipogenic or osteogenic differentiation of human mesenchymal progenitor cells (hMSCs) and of the single-cell–derived hMSC line (SCP-1), as well as ...
Source: Experimental and Clinical Endocrinology and Diabetes - January 19, 2020 Category: Endocrinology Authors: Komrakova, Marina Blaschke, Martina Ponce, Maria Laura Kl üver, Anne K öpp, Regine H üfner, Michael Schieker, Matthias Miosge, Nicolai Siggelkow, Heide Tags: Article Source Type: research

Estrogen signaling increases nuclear receptor subfamily 4 group A member 1 expression and energy production in skeletal muscle cells.
Authors: Nagai S, Ikeda K, Horie-Inoue K, Takeda S, Inoue S Abstract Estrogen deficiency has been known to associate with musculoskeletal diseases in women, based on the clinical observations of frequent susceptibility to osteoporosis and sarcopenia among postmenopausal women. In skeletal muscles, estrogen has been assumed to play physiological roles in maintaining muscle mass and strength, although its precise molecular mechanism remains to be elucidated. We have previously shown that estrogen regulates energy metabolism through the downregulation of mitochondrial uncoupling protein 3 (UCP3) in skeletal muscles, w...
Source: Endocrine Journal - October 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Serpina3n, dominantly expressed in female osteoblasts, suppresses the phenotypes of differentiated osteoblasts in mice.
In conclusion, we first found Serpina3n as the most female osteoblast-dominant gene. Serpina3n exerts a suppression of the osteoblast phenotypes such as Col1a1 expression and ALP activity in differentiated osteoblasts, which might partly explain sex differences of the osteoblast phenotypes in mice. PMID: 30304388 [PubMed - as supplied by publisher]
Source: Endocrinology - October 9, 2018 Category: Endocrinology Authors: Ishida M, Kawao N, Okada K, Tatsumi K, Sakai K, Nishio K, Kaji H Tags: Endocrinology Source Type: research

MiR-106a increases granulosa cell viability and is down-regulated in women with diminished ovarian reserve.
Conclusions: Down-regulation of miR-106a may contribute to the pathogenesis of DOR by reducing granulosa cell viability and promoting apoptosis via enhanced ASK1 signaling. PMID: 29590425 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 23, 2018 Category: Endocrinology Authors: Hong L, Peng S, Li Y, Fang Y, Wang Q, Klausen C, Yin C, Wang S, Leung PCK, Yang X Tags: J Clin Endocrinol Metab Source Type: research

Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia
Publication date: 15 March 2015 Source:Molecular and Cellular Endocrinology, Volume 404 Author(s): Juan-Li Yan , Jian Zhou , Hui-Ping Ma , Xiao-Ni Ma , Yu-Hai Gao , Wen-Gui Shi , Qing-Qing Fang , Qian Ren , Cory J. Xian , Ke-Ming Chen Although pulsed electromagnetic fields (PEMFs) have been approved as a therapy for osteoporosis, action mechanisms and optimal parameters are elusive. To determine the optimal intensity, exposure effects of 50 Hz PEMFs of 0.6–3.6 mT (0.6 interval at 90 min/day) were investigated on proliferation and osteogenic differentiation of cultured calvarial osteoblasts. All intensity groups sti...
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research

Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion.
Abstract In diabetic patients, advanced glycation end products (AGEs) cause bone fragility because of deterioration of bone quality. We previously showed that AGEs suppressed the mineralization of mouse stromal ST2 cells. Transforming growth factor (TGF)-β is abundant in bone, and enhancement of its signal causes bone quality deterioration. However, whether TGF-β signaling is involved in the AGE-induced suppression of mineralization during the osteoblast lineage remains unknown. We therefore examined the roles of TGF-β in the AGE-induced suppression of mineralization of ST2 cells and human mesenchymal stem cell...
Source: Endocrinology - April 23, 2014 Category: Endocrinology Authors: Notsu M, Yamaguchi T, Okazaki K, Tanaka KI, Ogawa N, Kanazawa I, Sugimoto T Tags: Endocrinology Source Type: research