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DNA methylation regulates Sirtuin 1 expression in osteoarthritic chondrocytes
CONCLUSIONS: Our results suggest the impact of DNA methylation on SIRT1 suppression in OA chondrocytes contributing to OA pathogenesis.PMID:36913826 | DOI:10.1016/j.advms.2023.02.002
Source: Advances in Medical Sciences - March 13, 2023 Category: Biomedical Science Authors: Aliki-Alexandra Papageorgiou Malamo Litsaki Evanthia Mourmoura Ioanna Papathanasiou Aspasia Tsezou Source Type: research

High TRB3 expression induces chondrocyte autophagy and senescence in osteoarthritis cartilage
CONCLUSIONS: Interfering with TRB3 expression in cartilage may serve as a target in the prevention and treatment of age-related osteoarthritis.PMID:35776529 | DOI:10.18632/aging.204066
Source: Aging - July 1, 2022 Category: Biomedical Science Authors: Yanqing Gu Ren Yan Yang Wang Yiwen Zeng Qingqiang Yao Source Type: research

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.
This study aims to explore the effect of p38 mitogen-activated protein kinase and its downstream target HMG-box transcription factor 1 (HBP1) in the chondrocyte (CH) senescence caused by hyperosmotic stress. Human cartilage tissue with or without osteoarthritis (OA) were collected to detect the differential expression of p38 and HBP1 by Western blot. CHs were isolated from cartilage without OA and used the hyperosmotic medium to accelerate CH senescence in vitro. A p38 inhibitor and siRNA were used to mediate the expression of p38 and HBP1. The viability of CHs was determined by cell counting kit 8 (CCK8) assay. CH-related...
Source: Journal of Biological Regulators and Homeostatic Agents - June 20, 2020 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Biphasic activation of nuclear factor-kappa B in chondrocyte death induced by interleukin-1beta: The expression of inducible nitric oxide synthase and phagocyte-type NADPH oxidase through immediate and monocarboxylate transporter-1-mediated late-phase activation of nuclear factor-kappa B
Conclusion We found that MCT-1 contributed to the expression of NOX-2 via late-phase activation of nuclear factor κB in a ROS-dependent manner in cells exposed to IL-1β. Hence, MCT-1 could be a potential target for the treatment of degenerative joint diseases.
Source: Journal of Oral Biosciences - February 24, 2016 Category: Biomedical Science Source Type: research