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Specialty: Cytology
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Total 135 results found since Jan 2013.
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
In conclusion, AMPK activation is an obvious inducer of ADAM10 shedding activity. Our findings suggest that AMPK boosts ADAM10 shedding activity in HAECs by promoting Rab14-dependent ADAM10 cell surface translocation.PMID:37451218 | DOI:10.1016/j.bbrc.2023.07.010
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Chung Hee Baek Hyosang Kim Soo Young Moon Won Seok Yang Source Type: research
IL-1 β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
In this study, we examined the activation of non-canonical nuclear factor Kappa B (NFκB) signalling in U2OS cells, a cellular metastatic bone cancer model. Whilst Lymphotoxin α1β2 (LTα1β2) stimulated the expected slow, delayed, sustained activation of serine 866/870 p100 phosphorylation and increased cellular expression of p52 NFκB, we found that canonical agonists, Interleukin-1β (IL-1β) and also Tumour necrosis factor-α (TNFα) generated a rapid transient increase in pp100, which was maximal by 15-30 min. This rapid phosphorylation was also observed in other cells types, such as DU145 and HCAECs suggesting the p...
Source: Cellular Signalling - April 20, 2023 Category: Cytology Authors: Kathryn McIntosh Yousif H Khalaf Rachel Craig Christopher West Ashley McCulloch Ajay Waghmare Christopher Lawson Edmond Y W Chan Simon Mackay Andrew Paul Robin Plevin Source Type: research
STAMP2 alleviates microglial neurotoxicity by inhibiting LPS-induced NF- κB activation
ConclusionThese findings revealed that STAMP2 is involved in regulating the LPS-NF-kB signal pathway to modulate inflammatory processes in microglia cells, which could represent a possible therapeutic therapy for neurodegenerative disorders.Graphical abstract
Source: Molecular and Cellular Toxicology - March 10, 2023 Category: Cytology Source Type: research
A20 functions as a negative regulator of the lipopolysaccharide-induced inflammation in corneal epithelial cells
Exp Eye Res. 2023 Jan 27:109392. doi: 10.1016/j.exer.2023.109392. Online ahead of print.ABSTRACTA20, also called TNFAIP3, is a crucial regulator of inflammation in various diseases but has not evidenced its function in the cornea. We aimed to evaluate the existence and the functions of A20 in human corneal epithelial (HCE-T) cells. After being treated with lipopolysaccharide (LPS) in different concentrations or at separate times, cells were collected to analyze A20 expressions. We then constructed the A20 knockdown system by siRNA and the A20 overexpressing system by lentivirus transduction. Systems were further exposed to...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Yubin Yu Kunke Li Ran Xue Sihao Liu Xiuping Liu Kaili Wu Source Type: research
Strontium-modified titanium substrate promotes osteogenic differentiation of MSCs and implant osseointegration via upregulating CDH2
In this study, transcriptome analysis of peri-implant bone tissue was performed, and N-cadherin (CDH2) was selected as a key mediator of Sr-SLA-mediated osseointegration. In vitro validation experiments have confirmed that indeed, CDH2 expression in MSCs on Sr-SLA was higher than the control group, which was in parallel with the enhanced cell migration, adhesion, and upregulation of early osteogenic markers. Knocking down CDH2 in MSCs resulted in decreased cell viability and osteogenic differentiation, and the elevated biocompatibility and osteoinductive effect of Sr-SLA were greatly diminished. Surprisingly, Sr-SLA-induce...
Source: Cell Research - January 24, 2023 Category: Cytology Authors: Chuan Zhou Ziyu Ge Lu Song Jiahui Yan Xinrui Lang Yanzhen Zhang Fuming He Source Type: research
Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway
J Bioenerg Biomembr. 2022 Dec 23. doi: 10.1007/s10863-022-09954-3. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury is a major cause of poor hemodynamic reconstitution outcomes after myocardial infarction or circulatory arrest. Currently, the search for effective therapeutic agents and tools is a focus of research in the field of myocardial I/R injury. Resveratrol (Res) has been extensively studied in recent years because of its good cardiovascular therapeutic effects, but its specific mechanism of action has not been fully elucidated. Therefore, the aim of this study was to investigate the mechan...
Source: Cell Research - December 23, 2022 Category: Cytology Authors: Hao Tian Yonghong Xiong Zhongyuan Xia Source Type: research
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
In this study, we investigated the neuroprotective effects and underlying mechanism for WFA in the regulation of ICH-induced oxidative stress and ferroptosis. We established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced ICH. WFA was injected intracerebroventricularly at 0.1, 1 or 5 µg/kg once daily for 7 days, starting immediately after ICH operation. WFA markedly reduced brain tissue injury and iron deposition and improved neurological function in a dose-dependent manner 7 days after cerebral hemorrhage. Through in vitro experiments,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Zi-Xian Zhou Qi Cui Ying-Mei Zhang Jia-Xin Yang Wen-Jing Xiang Ning Tian Yan-Lin Jiang Mei-Ling Chen Bin Yang Qing-Hua Li Ru-Jia Liao Source Type: research
Inhibition of TRPC6 suppressed TGF β-induced fibroblast-myofibroblast transdifferentiation in renal interstitial NRK-49F cells
In conclusion, we demonstrate that TRPC6 is a key regulator of TGF-β1-induced fibroblast-myofibroblast transdifferentiation and provides the mechanism of how TGF-β1 exposure regulates TRPC6 expression in NRK-49F fibroblasts.PMID:36206825 | DOI:10.1016/j.yexcr.2022.113374
Source: Experimental Cell Research - October 7, 2022 Category: Cytology Authors: Shan Jiang Lifei Gu Yixin Hu Younan Ren Zhao Yang Chengzhi Chai Boyang Yu Haitao Ge Zhengyu Cao Fang Zhao Source Type: research
Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage
This study aimed to explore the mechanism by which miR-410 transferred by bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) may alleviate hypoxic-ischemic brain damage (HIBD) in newborn mice. BMSCs were isolated from total bone marrow cells of femur and tibia of newborn mice, and primary neurons were extracted from the cerebral cortex of newborn mice within 24 h of birth. EVs were extracted from BMSCs transfected with the mimic or inhibitor of miR-410. Primary neurons were subjected to hypoxia and treated with overexpression (oe)-HDAC4, small interfering RNA (siRNA)-β-catenin, or Wnt path...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Mingqi Shen Rongxiu Zheng Xuan Kan Source Type: research
PGC-1 α attenuates TNF-α-induced inflammatory responses in OCCM-30 cells
CONCLUSIONS: PGC-1α can attenuate TNF-α-induced inflammatory responses in OCCM-30 cells.PMID:35903958 | DOI:10.1111/jre.13042
Source: Cell Research - July 29, 2022 Category: Cytology Authors: Yihui Fu Mingyuan Du Zhengguo Cao Hong He Source Type: research
