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Condition: Rheumatoid Arthritis
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Total 183 results found since Jan 2013.

Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research

Anti-HPV16 oncoproteins siRNA therapy for cervical cancer using a novel transdermal peptide PKU12
In conclusion, the transdermal peptide PKU12 is potentially a good candidate for a siRNA delivery vehicle for the treatment of cervical cancer.PMID:37350944 | PMC:PMC10282752 | DOI:10.3389/fonc.2023.1175958
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Yan Deng Yi Song Quan Du Chi Chiu Wang Hu Li Yi Sui Yuying Zhang Tao Tang Source Type: research

CD5L aggravates rheumatoid arthritis progression via promoting synovial fibroblasts proliferation and activity
In conclusion, CD5L promote RA disease progression via activating RASFs. CD5L blocking is a potential therapeutic approach for RA patients.PMID:37191481 | DOI:10.1093/cei/uxad054
Source: Clinical and Developmental Immunology - May 16, 2023 Category: Allergy & Immunology Authors: Xia-Nan Wu Zhao-Wei Gao Lan Yang Juan Zhang Chong Liu Hui-Zhong Zhang Ke Dong Source Type: research

Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1 α
ConclusionGlycolysis provides additional energy to sustain Rho/ROCK activation in RA subjects, which promotes VEGF-driven angiogenesis and can be inhibited by SIRT1 activation.
Source: Inflammation Research - April 4, 2023 Category: Research Source Type: research