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Total 1499 results found since Jan 2013.

Tongxinluo attenuates oxygen-glucose-serum deprivation/restoration-induced endothelial barrier breakdown via peroxisome proliferator activated receptor-α/angiopoietin-like 4 pathway in high glucose-incubated human cardiac microvascular endothelial cells
Conclusion: These data suggest cell-intrinsic and endothelial-specific Angptl4 mediates the protection of TXL against endothelial barrier breakdown during oxygen-glucose-serum deprivation and restoration under high glucose condition partly via the PPAR-α/Angptl4 pathway.
Source: Medicine - August 21, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/ β-catenin signaling pathway
CONCLUSIONS: TSIIA was able to attenuate high glucose-induced EMT in HK2 cells by up-regulating VDR levels, which might be related to the inhibitory effect of VDR on the Wnt pathway.PMID:34852178 | DOI:10.5603/FHC.a2021.0025
Source: Folia Histochemica et Cytobiologica - December 1, 2021 Category: Cytology Authors: Jingyi Zeng Xiaorong Bao Source Type: research

PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease
ConclusionsThese findings provide evidence that PFKP may be a potential target for podocyte injury in DN and provide a rationale for applying podocyte glycolysis enhancing agents in patients with DKD.
Source: Frontiers in Endocrinology - January 14, 2022 Category: Endocrinology Source Type: research

Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research

Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1
In this study, we explored whether metformin improves a high-glucose-induced senescence and fibrosis of renal tubular epithelial cells through cell cycle-related protein E2F1. In the in vivo experiments, the recombinant adeno-associated virus (AAV-shE2F1) knockdown E2F1 gene was injected into the tail vein of 16-weeks-old db/db mice for 8 weeks. The 16-week-old db/db mice were administered metformin (260 mg/kg/d) continuously for 8 weeks. The normal control group (NC) and diabetic model group (DM) were set up simultaneously. Mice renal tubular epithelial cells (mRTECs) were cultured in vitro. The cells were randomly div...
Source: Frontiers in Pharmacology - June 23, 2022 Category: Drugs & Pharmacology Source Type: research