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KLF14 and SK1 Lipid Signaling DNA and Chromosomes
In this study, we identified SK1 as a target of the canonical FGF2/FGF receptor 1 activation pathway in endothelial cells and sought to identify novel transcriptional pathways that mediate lipid signaling. Studies using the 1.9-kb SK1 promoter and deletion mutants revealed that basal and FGF2-stimulated promoter activity occurred through two GC-rich regions located within 633 bp of the transcription start site. Screening for GC-rich binding transcription factors that could activate this site demonstrated that KLF14, a gene implicated in obesity and the metabolic syndrome, binds to this region. Congruently, overexpression o...
Source: Journal of Biological Chemistry - May 30, 2014 Category: Chemistry Authors: de Assuncao, T. M., Lomberk, G., Cao, S., Yaqoob, U., Mathison, A., Simonetto, D. A., Huebert, R. C., Urrutia, R. A., Shah, V. H. Tags: Gene Regulation Source Type: research

Resistin regulates the expression of plasminogen activator inhibitor-1 in 3T3-L1 adipocytes.
In this study, to clarify the relationship between expression of resistin and PAI-1, PAI-1 expression in differentiated 3T3-L1 adipocytes was measured after transfection with anti-resistin siRNA. We found that PAI-1 gene expression and secreted PAI-1 protein were significantly decreased by resistin knockdown. Furthermore, phosphorylation of Akt, which can inhibit PAI-1 expression, was accelerated and the activity of protein phosphatase 2A (PP2A) was suppressed in resistin knockdown 3T3-L1 adipocytes. In addition, the expression of glucose transporter type 4, a ChREBP target gene, was reduced and was associated with inhibit...
Source: Biochemical and Biophysical Research communications - March 22, 2014 Category: Biochemistry Authors: Ikeda Y, Tsuchiya H, Hama S, Kajimoto K, Kogure K Tags: Biochem Biophys Res Commun Source Type: research

Resistin affects lipid metabolism during adipocyte maturation of 3T3‐L1 cells
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - September 5, 2013 Category: Research Authors: Yoshito Ikeda, Hiroyuki Tsuchiya, Susumu Hama, Kazuaki Kajimoto, Kentaro Kogure Tags: Original Article Source Type: research

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK Research Articles
ETC-1002 is an investigational drug currently in Phase 2 development for treatment of dyslipidemia and other cardiometabolic risk factors. In dyslipidemic subjects, ETC-1002 not only reduces plasma LDL cholesterol but also significantly attenuates levels of hsCRP, a clinical biomarker of inflammation. Anti-inflammatory properties of ETC-1002 were further investigated in primary human monocyte-derived macrophages and in in vivo models of inflammation. In cells treated with ETC-1002, increased levels of AMP-activated protein kinase (AMPK) phosphorylation coincided with reduced activity of MAP kinases and decreased production...
Source: The Journal of Lipid Research - July 10, 2013 Category: Lipidology Authors: Filippov, S., Pinkosky, S. L., Lister, R. J., Pawloski, C., Hanselman, J. C., Cramer, C. T., Srivastava, R. A. K., Hurley, T. R., Bradshaw, C. D., Spahr, M. A., Newton, R. S. Tags: Research Articles Source Type: research

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome
Conclusion In this model of MS, statin treatment reverses myocardial remodelling and improves ventricular relaxation through AMPK-mediated anti-fibrotic effects.
Source: Cardiovascular Research - June 20, 2013 Category: Cardiology Authors: Hermida, N., Markl, A., Hamelet, J., Van Assche, T., Vanderper, A., Herijgers, P., van Bilsen, M., Hilfiker-Kleiner, D., Noppe, G., Beauloye, C., Horman, S., Balligand, J.-L. Tags: Cardiac biology and remodelling Source Type: research

Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome
Conclusions This study demonstrates specific genomic alterations in HCC/MS and points to CUL7 as a novel gene potentially involved in liver carcinogenesis associated with MS, the amplification of which might influence cell proliferation.
Source: Gut - April 30, 2013 Category: Gastroenterology Authors: Paradis, V., Albuquerque, M., Mebarki, M., Hernandez, L., Zalinski, S., Quentin, S., Belghiti, J., Soulier, J., Bedossa, P. Tags: Hepatic cancer Hepatology Source Type: research

Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells.
In this study, we studied the influence of omentin-1 on two types of human hepatocellular carcinoma cells: HepG2 and HuH-7 cells. Cell viability assay showed that omentin-1 (1 and 2μg/ml) significantly inhibited the proliferation of HepG2 and HuH-7 cells. Both annexin+PI staining and TUNEL assay showed that omentin-1 induced apoptosis in these cells. Moreover, omentin-1 treatment upregulated protein levels of p53 and p21, a main transcriptional target of p53. Interestingly, omentin-1 did not affect p53 mRNA level. Further mechanism study showed that omentin-1 upregulated p53 protein level through decreasing p53 deacetylat...
Source: European Journal of Pharmacology - January 5, 2013 Category: Drugs & Pharmacology Authors: Zhang YY, Zhou LM Tags: Eur J Pharmacol Source Type: research

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