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Specialty: Cytology
Condition: Heart Failure
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Total 30 results found since Jan 2013.
SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF- β1
Cell Signal. 2023 Jun 19;109:110778. doi: 10.1016/j.cellsig.2023.110778. Online ahead of print.ABSTRACTCardiac fibroblasts (CFs) activation is a common response to most pathological conditions affecting the heart, characterized by increased cellular secretory capacity and increased expression of fibrotic markers, such as collagen I and smooth muscle actin type alpha (α-SMA). Fibrotic activation of CFs induces the increase in tissue protein content, with the consequent tissue stiffness, diastolic dysfunction, and heart failure. Therefore, the search for new mechanisms of CFs activation is important to find novel treatments...
Source: Cellular Signalling - June 21, 2023 Category: Cytology Authors: Fabiola Gonz ález-Herrera Mabel Catal án Renatto Anfossi Juan Diego Maya Zully Pedrozo Guillermo D íaz-Araya Ra úl Vivar Source Type: research
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1
Phytother Res. 2023 May 1. doi: 10.1002/ptr.7831. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and development of DCM. Additionally, the upregulation/activation of silent information regulation 2 homolog-1 (SIRT1) has been shown to protect against DCM. Tanshinone II A (Tan IIA), the main active component of Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), has protective effe...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Shun Wu Dingchun Lu Babu Gajendran Qilan Hu Jian Zhang Shengquan Wang Minzhen Han Yini Xu Xiangchun Shen Source Type: research
Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury
In conclusion, we successfully constructed Ndufs4 siRNA recombinant adenovirus; furthermore, the downexpression of the Ndufs4 gene may alleviate H2O2-induced H9c2 cell apoptosis.PMID:36741296 | PMC:PMC9897913 | DOI:10.1155/2023/8141129
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Beibei Wang Jinsheng Zhang Aijun Xu Source Type: research
Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression
CONCLUSIONS: Administration of two-dose hUCMSCs has better therapeutic effects than single-dose therapy for inhibiting myocardial inflammation to improve LV function in DCM rats. These effects are associated with upregulating IDO expression and its systemic anti-inflammatory activities.PMID:35962420 | DOI:10.1186/s13287-022-03101-w
Source: Cell Research - August 12, 2022 Category: Cytology Authors: Chenyi Gong Lei Chang Xuan Sun Yu Qi Rong Huang Ke Chen Bin Wang Lina Kang Lian Wang Biao Xu Source Type: research
Chaperone Mediated Autophagy Protects Cardiomyocytes Against Hypoxic-Cell Death
This study for the first time establishes a protective role for CMA (via Lamp2a overexpression) against hypoxia-induced cardiomyocyte loss and reveals the intriguing possibility that CMA activation may offer a cardioprotective treatment for ischemic heart disease.PMID:35584327 | DOI:10.1152/ajpcell.00369.2021
Source: Am J Physiol Cell Ph... - May 18, 2022 Category: Cytology Authors: Rajeshwary Ghosh Jennifer Jason Gillaspie Kenneth S Campbell J David Symons Sihem Boudina James Scott Pattison Source Type: research
