Filtered By:
Specialty: Cytology
Condition: Diabetes Type 2
This page shows you your search results in order of date.
Order by Relevance | Date
Total 24 results found since Jan 2013.
SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome
CONCLUSIONS: Our study for the first time demonstrates that CANA exerts a protective effect on vascular calcification at least partially via suppressing NLRP3 signaling pathway. Therefore, supplementation of CANA as well as inhibition of NLRP3 inflammasome presents a potential therapy for vascular calcification.PMID:37523743 | DOI:10.1093/cvr/cvad119
Source: Cell Research - July 31, 2023 Category: Cytology Authors: An Chen Zirong Lan Li Li Luting Xie Xiaoyu Liu Xiulin Yang Siyi Wang Qingchun Liang Qianqian Dong Liyun Feng Yining Li Yuanzhi Ye Mingwei Fu Lihe Lu Jianyun Yan Source Type: research
Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research
Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides
CONCLUSION: lEVs mediate the induction of apoptosis in endothelial cells in response to hyperglycemic injury through intercellular transfer of ceramides.PMID:34951654 | DOI:10.1007/s00018-021-04049-5
Source: Cellular and Molecular Life Sciences : CMLS - December 24, 2021 Category: Cytology Authors: Andreas Zietzer Alina Lisann Jahnel Marko Bulic Katharina Gutbrod Philip D üsing Mohammed Rabiul Hosen Peter D örmann Nikos Werner Georg Nickenig Felix Jansen Source Type: research
Human umbilical cord mesenchymal stem cells reduce oxidative damage and apoptosis in diabetic nephropathy by activating Nrf2
CONCLUSIONS: hUCMSCs attenuated renal oxidative damage and apoptosis in type 2 diabetes mellitus and Nrf2 activation is one of the important mechanisms of this effect. hUCMSCs show potential as drug targets for DN.PMID:34380544 | DOI:10.1186/s13287-021-02447-x
Source: Cell Research - August 12, 2021 Category: Cytology Authors: Ping Nie Xue Bai Yan Lou Yuexin Zhu Shan Jiang Lina Zhang Na Tian Ping Luo Bing Li Source Type: research
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca < sup > 2+ < /sup > -PPP3/calcineurin-TFEB axis
Autophagy. 2021 Aug 2:1-17. doi: 10.1080/15548627.2021.1956123. Online ahead of print.ABSTRACTMacroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (glucagon like peptide 1 receptor) agonist exendin-4 stimulates autophagic flux in a setting of chronic nutrient excess. The aim of this study was to identify the underlying pathways contributing to enhanced autophagic flux.Pancreatic β-cells (INS-1E),mouse and human islets were treated...
Source: Autophagy - August 2, 2021 Category: Cytology Authors: Francesco P Zummo Stanislaus I Krishnanda Merilin Georgiou Finbarr Pm O'Harte Vadivel Parthsarathy Kirsty S Cullen Minna Honkanen-Scott James Am Shaw Penny E Lovat Catherine Arden Source Type: research
Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes.
CONCLUSION: Combined AT and RT is an effective way to improve EPC function through upregulation of caveolin-1 in mice with type 2 diabetes.
PMID: 31900223 [PubMed - in process]
Source: Cell Research - January 2, 2020 Category: Cytology Authors: Zhai L, Liu Y, Zhao W, Chen Q, Guo T, Wei W, Luo Z, Huang Y, Ma C, Huang F, Dai X Tags: Stem Cell Res Ther Source Type: research
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
In conclusion, our results showed that the pathophysiological factors in type 2 diabetes, including AGEs, were able to induce centrosome amplification. It is suggested that secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway which is upstream of ROCK1 and 14-3-3σ, which is the cell signaling pathway underlying the diabetes-associated centrosome amplification.
PMID: 31618077 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - October 15, 2019 Category: Cytology Authors: He QJ, Wang P, Liu Q, Wu Q, Li YF, Wang J, Lee SC Tags: Am J Physiol Cell Physiol Source Type: research
The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes
Conclusion: These results suggest a potentially important new mechanism that regulates glucose transport in podocytes and that could be injurious during diabetes.Cell Physiol Biochem 2018;51:393 –410
Source: Cellular Physiology and Biochemistry - November 19, 2018 Category: Cytology Source Type: research
Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF- κB/MAPK/ PI3K Signaling Systems
Conclusion: Collectively, our results show that palmitate induces CCL4 expression via activation of the TLR4-MyD88/NF-kB/MAPK/ PI3K signaling cascade. Thus, our findings suggest that the palmitate-induced CCL4 production might be an underlying mechanism of metabolic inflammation.Cell Physiol Biochem 2018;46:953 –964
Source: Cellular Physiology and Biochemistry - April 18, 2018 Category: Cytology Source Type: research
Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research
