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SIRT3 attenuates coronary atherosclerosis in diabetic patients by regulating endothelial cell function
CONCLUSION: SIRT3 was associated with the progression of atherosclerosis in T2DM patients through upregulation of PPAR-α and eNOS and downregulation of iNOS, which are involved in endothelial dysfunction under hyperglycemic conditions.PMID:35791925 | DOI:10.1002/jcla.24586
Source: Atherosclerosis - July 6, 2022 Category: Cardiology Authors: Huiping Gong Jing Liu Zhiwei Xue Wenwen Wang Cuicui Li Fanfan Xu Yimeng Du Xiaona Lyu Source Type: research

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis
Conclusion: Our findings indicate that the positive role of RES in diabetic wound healing via its SIRT1-dependent endothelial protection and pro-angiogenic effects involves the inhibition of FOXO1 and the de-repression of c-Myc expression. Introduction Diabetes mellitus is a metabolic disease with an increasing incidence worldwide (Zimmet et al., 2014). The disease often leads to the development of serious complications such as microangiopathy, mainly including retinopathy, nephropathy, neuropathy, and diabetic non-healing skin ulcers (Zheng et al., 2018). Diabetic non-healing skin ulcers such as foot ulcers are ca...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Hepatic miR-181b-5p Contributes to Glycogen Synthesis Through Targeting EGR1
ConclusionWe demonstrated that miR-181b-5p contributes to glycogen synthesis by targeting EGR1, thereby regulating PTEN expression to mediate hepatic insulin resistance.
Source: Digestive Diseases and Sciences - January 9, 2019 Category: Gastroenterology Source Type: research

CIDEC Gene Silencing Alleviates Pulmonary Vascular Remodeling in a Type 2 Diabetic Rat Model
ConclusionsCIDEC/AMPK signaling pathway could be a potential therapeutic candidate against pulmonary vascular diseases in type 2 diabetes.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - September 1, 2017 Category: Endocrinology Authors: Dong ‐xin Sui, Hui‐min Zhou, Feng Wang, Ming Zhong, Wei Zhang, Yun Ti Tags: Original Article Source Type: research