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Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity
J Biomed Res. 2022 May 15:1-14. doi: 10.7555/JBR.36.20210198. Online ahead of print.ABSTRACTThe present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid (GA) in diabetic peripheral neuropathy (DPN). GA significantly mitigated nerve conduction velocity (NCV) deficit and morphological abnormality and reduced high-mobility group box-1 (HMGB1) expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight. Notably, GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells. Furthermore, GA obviously reduced the...
Source: Biomed Res - May 17, 2022 Category: Research Authors: Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han Source Type: research

Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes.
Authors: Zou F, Lai X, Li J, Lei S, Hu L Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the activation of CD4+ T cells induced by proinsulin is alleviated in T1DM patients, and CatG-specific inhibitor reduces the activation of CD4+ cells induced by proinsulin in T1DM patients. Therefore, we hypothesize that CatG may play an important role in the a...
Source: American Journal of Translational Research - December 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Silencing of TRB3 Ameliorates Diabetic Tubule Interstitial Nephropathy via PI3K/AKT Signaling in Rats.
CONCLUSIONS Silencing of TRB3 has a significant ameliorative effect on diabetic nephropathy in rats. PMID: 28600485 [PubMed - in process]
Source: Medical Science Monitor - June 11, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Beta-adrenergic receptor agonist decreases VEGF levels through altered eNOS and PKC signaling in diabetic retina.
Authors: Jiang Y, Zhang Q, Steinle JJ Abstract Vascular endothelial cell growth factor (VEGF) is increased in diabetic macular edema. Compound 49b, a novel β-adrenergic receptor agonist, is protective in a type 1 diabetic rat model. We questioned whether Compound 49b could decrease VEGF levels, suggesting that Compound 49b may be effective against edema. Two-month diabetic rats received topical Compound 49b for 7 days only and/or insulin-like growth factor binding protein 3 (IGFBP-3) siRNA. We also measured endothelial nitric oxide synthase (eNOS) and protein kinase C (PKC)ζ and PKCδ phosphorylation. Retinal end...
Source: Growth Factors - February 18, 2016 Category: Research Tags: Growth Factors Source Type: research

Featured Article: Selective blockade of the OGF-OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing
Naltrexone (NTX) is an opioid receptor antagonist that acts at classical and non-classical opioid receptors including the opioid growth factor receptor (OGFr). Animal models of type 1 and type 2 diabetes, as well as normal rodents, have shown that topical NTX enhances the healing rates of corneal epithelium and full-thickness cutaneous wounds. The mechanism of this general opioid antagonist on growth, and in particular the specific receptor pathway involved, is not understood. Tissue culture studies using NIH 3T3 fibroblasts and primary rat auricular fibroblasts were established to evaluate growth following opioid receptor...
Source: Experimental Biology and Medicine - September 29, 2014 Category: Research Authors: Immonen, J. A., Zagon, I. S., McLaughlin, P. J. Tags: Anatomy & amp;amp; Pathology Source Type: research