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Specialty: Neuroscience
Condition: Spinal Cord Injury
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Total 45 results found since Jan 2013.
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway
CONCLUSION: PXR is involved in the recovery of motor function after SCI by regulating NRF2/HO-1 pathway.PMID:37269088 | DOI:10.1111/cns.14279
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Li-Na Xuan Zhen-Xin Hu Zhen-Fu Jiang Cong Zhang Xiao-Wan Sun Wen-Hua Ming Hui-Tao Liu Rong-Fang Qiao Lin-Jie Shen Shao-Bo Liu Guan-Yu Wang Lin Wen Zhi-Lin Luan Jian Yin Source Type: research
SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons
CONCLUSION: SUMOylation of the Kir7.1 in the spinal cord might contribute to the development of SNI-induced mechanical allodynia by decreasing the Kir7.1 surface expression in rats.PMID:35633059 | DOI:10.1111/cns.13871
Source: CNS Neuroscience and Therapeutics - May 28, 2022 Category: Neuroscience Authors: You-You Lv Han Wang Hai-Ting Fan Ting Xu Wen-Jun Xin Rui-Xian Guo Source Type: research
Repair of Spinal Cord Injury by Inhibition of PLK4 Expression Through Local Delivery of siRNA-Loaded Nanoparticles
In conclusion, inhibition of PLK4 expression via siRNA-loaded nanoparticles may be a potential treatment for SCI.
Source: Journal of Molecular Neuroscience - September 1, 2021 Category: Neuroscience Source Type: research
Epigenetic Restoration of Voltage ‐gated Potassium Channel Kv1.2 Alleviates Nerve Injury‐induced Neuropathic Pain
AbstractVoltage ‐gated potassium channels (Kv) are important regulators of neuronal excitability for its role of regulating resting membrane potential and repolarization. Recent studies show that Kv channels participate in neuropathic pain, but the detailed underlying mechanisms are far from being clear. In the c urrent study, we used siRNA, miR‐137 agomir and antagomir to regulate the expression of Kv1.2 in spinal cord and dorsal root ganglia (DRG) of naïve and chronic constriction injury (CCI) rats. Kv currents and neuron excitability in DRG neurons were examined by patch‐clamp whole‐cell recording to verify the...
Source: Journal of Neurochemistry - July 2, 2020 Category: Neuroscience Authors: Jingjing Zhang,
Lina Rong,
Jinping Shao,
Yidan Zhang,
Yaping Liu,
Sen Zhao,
Lei Li,
Wenli Yu,
Mengya Zhang,
Xiuhua Ren,
Qingzan Zhao,
Changlian Zhu,
Huan Luo,
Weidong Zang,
Jing Cao Tags: ORIGINAL ARTICLE Source Type: research
MicroRNA ‐22‐3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5
AbstractCell death after spinal cord ischemia/reperfusion (I/R) can occur through necrosis, apoptosis and autophagy, resulting in changes to the immune environment. However, the molecular mechanism of this immune regulation is not clear. Accumulating evidence indicates that microRNAs (miRs) play a crucial role in the pathogenesis of spinal cord I/R injury. Here, we hypothesized miR ‐22‐3p may be involved in spinal cord I/R injury by interacting with interferon regulatory factor (IRF) 5. Rat models of spinal cord I/R injury were established by 12‐min occlusion of the aortic arch followed by 48‐h reperfusion, with L4...
Source: Journal of Neurochemistry - May 13, 2020 Category: Neuroscience Authors: Hua Fang,
Miao Yang,
Qin Pan,
Hon ‐Ling Jin,
Hua‐Feng Li,
Ru‐Rong Wang,
Quan‐Yun Wang,
Jian‐Ping Zhang Tags: ORIGINAL ARTICLE Source Type: research
Receptor for Activated C Kinase 1 Mediates the Chronic Constriction Injury-induced Neuropathic Pain in the Rats’ Peripheral and Central Nervous System
In this study, the biological effects and mechanisms of RACK1 contributes to the pathogenesis of chronic constriction injury (CCI)-induced neuropathic pain were investigated. By western blot and staining, we found that RACK1 protein changed in dorsal root ganglion (DRG) neurons and spinal cord (SC) neurons except glial cells after CCI. Especially, RACK1 was co-located with IB4-, CGRP-positive neurons, suggesting it was related to integrate nociceptive information from the primary afferents in DRG. The successful establishment of CCI models also directly led to mechanical allodynia and heat hyperalgesia, which could be rev...
Source: Neuroscience Letters - September 4, 2019 Category: Neuroscience Source Type: research
i-Fect used to Study Angiogenesis in Brain Injury
This study revealed that LDHA, which is a known damage marker, promotes CNS-specific angiogenesis. LDHA-mediated angiogenesis depends on vimentin on the surface of vascular endothelial cells. The work described here proposes a novel mechanism by which neurodegeneration drives angiogenesis in the CNS.A mixture of ouri-FectTM and LDHA siRNA, in this study, were directly injected into mice cortexes: Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita.Extracellular Lactate Dehydrogenase A Release ...
Source: siRNA and DsiRNA Transfection Efficiency - May 9, 2019 Category: Neuroscience Tags: Angiogenesis iFect TBI traumatic brain injury Source Type: news
HDAC2, but Not HDAC1, Regulates Kv1.2 Expression to Mediate Neuropathic Pain in CCI Rats
In this study we established a chronic constrictive injury (CCI) model and used western blot, quantitative real-time PCR, immunostaining, intrathecal injection, and siRNA methods to explore which HDAC subunit is involved in regulating Kv1.2 expression to mediate NPP. Our results demonstrated that nerve injury led to upregulation of HDAC1 expression in the DRG, and of HDAC2 in the DRG and spinal cord. Double-labeling immunofluorescence histochemistry showed that Kv1.2 principally co-localized with HDAC2, but not HDAC1, in NF200-positive large neurons of the DRG. Intrathecal injection with the HDAC inhibitor, suberoylanilide...
Source: Neuroscience - April 24, 2019 Category: Neuroscience Source Type: research
