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Cancer: Endometrial Cancer

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Total 190 results found since Jan 2013.

Impact of growth hormone-releasing hormone (GHRH) antagonist on Decidual stromal cell growth and apoptosis in vitro
Biol Reprod. 2021 Nov 18:ioab214. doi: 10.1093/biolre/ioab214. Online ahead of print.ABSTRACTEndometrial stromal cells remodeling is critical during human pregnancy. GHRH and its functional receptor have been shown to be expressed in gynecological cancer cells and eutopic endometrial stromal cells. Recent studies have demonstrated the potential clinical uses of antagonists of GHRH as effective antitumor agents because of its directly antagonistic effect on the locally produced GHRH in gynecological tumors. However, the impact of GHRH antagonists on normal endometrial stromal cell growth remained to be elucidated. The aim o...
Source: Reproductive Biology - November 18, 2021 Category: Reproduction Medicine Authors: Hsien-Ming Wu Liang-Hsuan Chen Andrew V Schally Hong-Yuan Huang Yung-Kuei Soong Peter C K Leung Hsin-Shih Wang Source Type: research

Follicle-Stimulating Hormone Induces Lipid Droplets via G αi/o and β-Arrestin in an Endometrial Cancer Cell Line
In this study, we identify an additional mechanism of FSH-mediated signaling and downstream function in the endometrial adenocarcinoma Ishikawa cell line. While FSH did not induce increases in cAMP levels, this hormone potently activated pertussis toxin sensitive Gαi/o signaling. A selective allosteric FSHR ligand, B3, also activated Gαi/o signaling in these cells, supporting a role for receptor-mediated activation despite the low levels of FSHR mRNA. The low expression levels may attribute to the lack of Gαs/cAMP signaling as increasing FSHR expression resulted in FSH-mediated activation of the Gαs pathway. Unlike pri...
Source: Frontiers in Endocrinology - February 3, 2022 Category: Endocrinology Source Type: research

Hypoxic induction of apoptosis occurs through HIF-1 α and accompanies mammalian sterile 20-like kinase 2 cleavage in human endometrial adenocarcinoma Ishikawa cells
Biochem Biophys Res Commun. 2022 Mar 4;604:104-108. doi: 10.1016/j.bbrc.2022.03.016. Online ahead of print.ABSTRACTThe incidence of endometrial cancer is increasing worldwide. One of the main causes of this cancer is a hormone imbalance; progesterone derivatives have been used for treatment. However, reports have shown that hypoxia plays important and possibly beneficial roles in endometrial function. Here, we show the effect of hypoxia on the proliferation of human endometrial adenocarcinoma Ishikawa cells. Hypoxia induced caspase-dependent apoptosis in Ishikawa cells. Overexpression and siRNA-mediated knockdown of hypoxi...
Source: Biochemical and Biophysical Research communications - March 18, 2022 Category: Biochemistry Authors: Jeonggeun Lee Namkyu Lee Hee Dong Han YoungJoo Lee Source Type: research

Cancers, Vol. 14, Pages 1877: The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers
s Borhane Annabi Sortilin (SORT1) receptor-mediated endocytosis functions were exploited for this new approach for effective and safe treatments of gynecological cancers. Here, high expression of SORT1 was found in >75% of the clinically annotated ovarian and endometrial tumors analyzed by immunohistochemistry. Therefore, the anticancer properties of the peptide-drug conjugate TH1902, a peptide that targets SORT1 and which is linked to docetaxel molecules, were investigated both in vitro using ovarian and endometrial cancer cell cultures and in vivo using xenograft models. In vitro, TH1902 inhibited cell p...
Source: Cancers - April 8, 2022 Category: Cancer & Oncology Authors: Jean-Christophe Currie Michel Demeule Cyndia Charfi Alain Zgheib Alain Larocque Bogdan Alexandru Danalache Amira Ouanouki Richard B éliveau Christian Marsolais Borhane Annabi Tags: Article Source Type: research

Metformin Regulates TET2 Expression to Inhibit Endometrial Carcinoma Proliferation: A New Mechanism
ConclusionsTET2 may play an important role in EC development and may be a prognostic marker. Moreover, TET2 may be involved in a novel mechanism by which metformin inhibits EC cell proliferation.
Source: Frontiers in Oncology - April 11, 2022 Category: Cancer & Oncology Source Type: research