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Specialty: Molecular Biology
Cancer: Lung Cancer
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Total 91 results found since Jan 2013.
A pancancer analysis of the oncogenic role of ZNRF2 in human tumours
J Cell Mol Med. 2023 Aug 8. doi: 10.1111/jcmm.17900. Online ahead of print.ABSTRACTFinding effective treatments for cancer requires a thorough understanding of how it develops and progresses. Recent research has revealed the crucial role that Zinc and ring finger 2 (ZNRF2) play in the progression of non-small cell lung cancer (NSCLC) by controlling cell growth and death. However, a comprehensive analysis of ZNRF2's role in cancer as a whole has yet to be conducted. Our study sought to investigate the impact of ZNRF2 on diverse human tumours, as well as the molecular pathways involved, using databases such as TCGA (The Canc...
Source: J Cell Mol Med - August 8, 2023 Category: Molecular Biology Authors: Fujie Shi Yunfei Wu Kai Wang Jiafan Wang Minghui Liu Xinlei Sun Source Type: research
Selective CDK9 knockdown sensitizes TRAIL response by suppression of antiapoptotic factors and NF-kappaB pathway
AbstractThe aberrantly up-regulated CDK9 can be targeted for cancer therapy. The CDK inhibitor dinaciclib (Dina) has been found to drastically sensitizes cancer response to TRAIL-expressing extracellular vesicle (EV-T). However, the low selectivity of Dina has limited its application for cancer. We propose that CDK9-targeted siRNA (siCDK9) may be a good alternative to Dina. The siCDK9 molecules were encapsulated into EV-Ts to prepare a complexed nanodrug (siEV-T). It was shown to efficiently suppress CDK9 expression and overcome TRAIL resistance to induce strikingly augmented apoptosis in lung cancer both in vitro and in v...
Source: Apoptosis - April 15, 2023 Category: Molecular Biology Source Type: research
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
CONCLUSION: Taken together, RPL11 has a tumor-promoting role in NSCLC. It promotes the cell proliferation of NSCLC cells by regulating ERS and autophagy.PMID:36869281 | PMC:PMC9985270 | DOI:10.1186/s12860-023-00469-2
Source: Mol Biol Cell - March 3, 2023 Category: Molecular Biology Authors: Jie Chen Changda Lei Huahua Zhang Xiaoyong Huang Yang Yang Junli Liu Yuna Jia Haiyan Shi Yunqing Zhang Jing Zhang Juan Du Source Type: research
Airborne particulate matter (PM < sub > 10 < /sub > ) induces cell invasion through Aryl Hydrocarbon Receptor and Activator Protein 1 (AP-1) pathway deregulation in A549 lung epithelial cells
CONCLUSION: Our results demonstrated that PM10 exposure induces upregulation of the c-Jun, Jun B, and Fra-1 activity, the expression/activity of MMP-9, and the cell invasion in lung epithelial cells, effects mediated through the AhR. Also, the Fos B and C-Fos activity were downregulated. In addition, the effects induced by PM10 exposure were like those induced by BaP, which highlights the potentially toxic effects of the PM10 mixture in lung epithelial cells.PMID:36309615 | DOI:10.1007/s11033-022-07986-x
Source: Mol Biol Cell - October 30, 2022 Category: Molecular Biology Authors: Roc ío Morales-Bárcenas Yesennia S ánchez-Pérez Miguel Santib áñez-Andrade Yolanda I Chirino Ernesto Soto-Reyes Claudia M Garc ía-Cuellar Source Type: research
Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling
Cell Mol Immunol. 2022 Oct 14. doi: 10.1038/s41423-022-00930-w. Online ahead of print.ABSTRACTThe interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role in promoting these events through paracrine communication. Here, we demonstrate that conditioned medium (CM) from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and CAFs. Direct exposure of CAFs to apoptotic 344SQ cells (ApoSQ) inhibited CAF migration and invasion and the expression of CAF acti...
Source: Cellular and Molecular Immunology - October 14, 2022 Category: Molecular Biology Authors: Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye-Ji Lee Sieun Lee Sung Yong Ahn Young-Ho Ahn Jihee Lee Kang Source Type: research
Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells
CONCLUSIONS: Data provided suggest that TGFβ1 modulates the expression of DUSP genes and that upregulation of DUSP26 may be required for TGFβ1-promoted EMT in A549 and PANC1 cells. Further studies should be carried out to elucidate the requirement of individual DUSPs in TGFβ1-associated EMT in tumor cells.PMID:36053282 | DOI:10.1007/s11033-022-07893-1
Source: Molecular Biology Reports - September 2, 2022 Category: Molecular Biology Authors: Sabire Guler Berrin Zik Abdullah Yalcin Source Type: research
