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Specialty: Pathology
Cancer: Glioma

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Total 20 results found since Jan 2013.

ERK-CREB pathway is involved in HSPB8-mediated glioma cell growth and metastatic properties
CONCLUSION: Silencing HSPB8 can inhibit the malignant features, while facilitate the apoptosis of glioma cells, with inactivation of ERK-CREB pathway.PMID:34043982 | DOI:10.1016/j.yexmp.2021.104653
Source: Experimental and Molecular Pathology - May 27, 2021 Category: Pathology Authors: Xia Li Cui Sun Jing Chen Ji-Fen Ma Yi-Heng Pan Source Type: research

The guanine nucleotide exchange factor, LARG, and RhoC play a role in glioblastoma cell invasion and resistance.
Abstract Glioblastoma (GBM) is the most common primary malignant brain cancer in adults. A hallmark of GBM is aggressive invasion of tumor cells into the surrounding normal brain. The current standard of care therapy, as well as targeted therapies, have largely failed to specifically address this issue. Therefore, identifying key regulators of GBM cell migration and invasion is of particular interest. The leukemia-associated RhoGEF (LARG) has previously been implicated in cell invasion in other tumor types; however, the role of LARG in GBM pathobiology remains undefined. Here, we report that the expression level o...
Source: The American Journal of Pathology - July 17, 2020 Category: Pathology Authors: Ding Z, Dong Z, Yang Y, Fortin Ensign SP, Sabit H, Nakada M, Ruggieri R, Kloss JM, Symons M, Tran NL, Loftus JC Tags: Am J Pathol Source Type: research

KDELR2 is an unfavorable prognostic biomarker and regulates CCND1 to promote tumor progression in glioma.
CONCLUSIONS: KDELR2 is highly expressed in human glioma tissues and cell lines, a higher expression of KDELR2 is associated with a poor prognosis of glioma patients. Moreover, KDELR2 regulated the cellular functions of U87 cells by targeting CCND1. The KDELR2/CCND1 axis may provide a new therapeutic target for the treatment of glioma and deepen our understanding of glioma mechanisms. PMID: 32534703 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - June 16, 2020 Category: Pathology Authors: Hui M, Nian J, Wang Z, Li X, Huang C Tags: Pathol Res Pract Source Type: research

Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis
ConclusionElevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway.
Source: Pathology Research and Practice - December 18, 2019 Category: Pathology Source Type: research

Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis.
CONCLUSION: Elevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway. PMID: 31864713 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - December 16, 2019 Category: Pathology Authors: Cheng L, Shao X, Wang Q, Jiang X, Dai Y, Chen S Tags: Pathol Res Pract Source Type: research

miR-452 promotes the development of gastric cancer via targeting EPB41L3
In this study, we found that miR-452 was highly expressed in both tumor tissue and gastric cancer cells, and could directly target the cancer suppressor gene EPB41L3 3′-UTR. miR-452 significantly promoted the proliferation, migration and the S-phase arrest of gastric cancer cells, but EPB41L3 as a downstream target gene of miR-452 reversed such promoting effect. While down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells, but this inhibitory effect was reversed by EPB41L3 siRNA. In addition, miR-452 in the gastric cancer xenograft model in nude mice could ...
Source: Pathology Research and Practice - November 1, 2019 Category: Pathology Source Type: research

Participation of tumor suppressors long non-coding RNA MEG3, microRNA-377 and PTEN in glioma cell invasion and migration
ConclusionsThese results suggested the link interaction of MEG3 with miR-377 and PTEN, but not functioning as the competing endogenous RNA. MiR-377 mimics and MEG3 were tumor suppressors in glioma cells through regulating PTEN expression.
Source: Pathology Research and Practice - July 24, 2019 Category: Pathology Source Type: research

Cell Division Cycle Associated 7 Like Predicts Unfavorable Prognosis and Promotes Invasion in Glioma
ConclusionsCDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients. Moreover, CDCA7L can promote glioma invasion, which can serve as an independent potential prognostic biomarker for glioma patients.
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research

Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.
CONCLUSIONS: CDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients. Moreover, CDCA7L can promote glioma invasion, which can serve as an independent potential prognostic biomarker for glioma patients. PMID: 30389317 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - October 24, 2018 Category: Pathology Authors: Shen FZ, Li XS, Ma JW, Wang XY, Zhao SP, Meng L, Liang SF, Zhao XL Tags: Pathol Res Pract Source Type: research

Knockdown of DSPP inhibits the migration and invasion of glioma cells
In this study, we aimed to investigate the expression and biological function of DSPP in human glioma cells. We demonstrated through Western blot that DSPP is overexpressed in glioma tissues comparing to normal brain tissues. To investigate the role of DSPP in glioma carcinogenesis, we reduced the DSPP expression by small interfering RNA (siRNA) and found that DSPP silencing significantly inhibited the migration and invasion of glioma cells, the critical characteristics of glioma. Furthermore, we showed that DSPP down-regulation significantly decreased the activation of the AKT/mTOR/p70S6K pathway in glioma cells. Taken to...
Source: Pathology Research and Practice - October 5, 2018 Category: Pathology Source Type: research

Gpx 4 is involved in the proliferation, migration and apoptosis of glioma cells
In this report, we defined Gpx4 as a therapeutic target for glioma. Western blot and immunohistochemistry(IHC) analysis revealed that the protein level of Gpx4 was higher in glioma tissues and cell lines. In addition, IHC stain revealed that there was statistical significance between the expression of Gpx4 and the WHO grade (P=0.004) and Ki-67(P=0.000) expression. Kaplan–Meier curve showed that high expression of Gpx4 was associated with poor prognosis of glioma patients (P <0.01). To determine whether Gpx4 could regulate the proliferation and migration of glioma cells, we transfected glioma cells with Gpx4-siRNA ...
Source: Pathology Research and Practice - May 5, 2017 Category: Pathology Source Type: research

Gpx 4 is involved in the proliferation, migration and apoptosis of glioma cells.
In this report, we defined Gpx4 as a therapeutic target for glioma. Western blot and immunohistochemistry(IHC) analysis revealed that the protein level of Gpx4 was higher in glioma tissues and cell lines. In addition, IHC stain revealed that there was statistical significance between the expression of Gpx4 and the WHO grade (P=0.004) and Ki-67(P=0.000) expression. Kaplan-Meier curve showed that high expression of Gpx4 was associated with poor prognosis of glioma patients (P<0.01). To determine whether Gpx4 could regulate the proliferation and migration of glioma cells, we transfected glioma cells with Gpx4-siRNA and the...
Source: Pathology, Research and Practice - May 4, 2017 Category: Pathology Authors: Zhao H, Ji B, Chen J, Huang Q, Lu X Tags: Pathol Res Pract Source Type: research