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Cancer: Wilm's Tumor
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Total 11 results found since Jan 2013.
Overexpression of Wilms tumor 1 promotes IL-1 β expression by upregulating histone acetylation in keratinocytes
Int Immunopharmacol. 2021 Jul;96:107793. doi: 10.1016/j.intimp.2021.107793. Epub 2021 Jun 2.ABSTRACTPsoriasis is a common inflammatory skin disease. Infiltration of inflammatory cells and excessive proliferation of keratinocytes are the histopathological markers of psoriasis. The transcription factor Wilms Tumor 1 (WT1) is overexpressed in several tumor types, and plays an important part in the proliferation and apoptosis of cells. Studies have found that, compared with normal skin, WT1expression in the skin lesions of patients with psoriasis are increased significantly. Knockdown of WT1 inhibited the proliferation of a hu...
Source: International Immunopharmacology - June 24, 2021 Category: Allergy & Immunology Authors: Yuan Liao Yuwen Su Ruifang Wu Peng Zhang Chun Feng Source Type: research
WTAP facilitates progression of endometrial cancer via CAV-1/NF- κB axis.
This article is protected by copyright. All rights reserved.
PMID: 33559954 [PubMed - as supplied by publisher]
Source: Cell Biology International - February 9, 2021 Category: Cytology Authors: Li Q, Wang C, Dong W, Su Y, Ma Z Tags: Cell Biol Int Source Type: research
Wilms tumor 1 regulates lipid accumulation in human endometrial stromal cells during decidualization Gene Regulation
We previously reported that the transcription factor Wilms tumor 1 (WT1) regulates the expression of insulin-like growth factor-binding protein-1 (IGFBP-1) and prolactin (PRL) during decidualization of human endometrial stromal cells (ESCs). However, other roles of WT1 in decidualization remain to be fully clarified. Here, we investigated how WT1 regulates the physiological functions of human ESCs during decidualization. We incubated ESCs isolated from proliferative-phase endometrium with cAMP to induce decidualization, knocked down WT1 with siRNA, and generated three types of treatments (nontreated cells, cAMP-treated cel...
Source: Journal of Biological Chemistry - April 2, 2020 Category: Chemistry Authors: Isao Tamura, Haruka Takagi, Yumiko Doi-Tanaka, Yuichiro Shirafuta, Yumiko Mihara, Masahiro Shinagawa, Ryo Maekawa, Toshiaki Taketani, Shun Sato, Hiroshi Tamura, Norihiro Sugino Tags: Gene Regulation Source Type: research
Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1.
In this study, we found that MgIG significantly alleviated kidney dysfunction, proteinuria and podocyte injury in fructose-fed rats. It also restored fructose-induced podocyte apoptosis in rat glomeruli and cultured differentiated podocytes. Of note, high-expression of miR-193a, downregulation of Wilms' tumor protein (WT1) and RelA, as well as upregulation of C-Maf inducing protein (C-mip) were observed in these animal and cell models. The data from the transfection of miR-193a mimic, miR-193a inhibitor, WT1 siRNA or LV5-WT1 in cultured differentiated podocytes showed that fructose increased miR-193a to down-regulate WT1, ...
Source: Biochemical Pharmacology - May 10, 2019 Category: Drugs & Pharmacology Authors: Li TS, Chen L, Wang SC, Yang YZ, Xu HJ, Gu HM, Zhao XJ, Dong P, Pan Y, Shang ZQ, Zhang XQ, Kong LD Tags: Biochem Pharmacol Source Type: research
The Functions of Non-coding RNAs in rRNA Regulation
Qi Yan1, Chengming Zhu1, Shouhong Guang1,2* and Xuezhu Feng1*
1Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
2CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Hefei, China
Ribosomes are ribonucleoprotein machines that decode the genetic information embedded in mRNAs into polypeptides. Ribosome biogenesis is tightly coordinated and controlled from the transcription of pre-rRNAs to the assembly of ribosomes. Defects or disorders in rRNA production result in a number of human ri...
Source: Frontiers in Genetics - April 4, 2019 Category: Genetics & Stem Cells Source Type: research
Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis.
Abstract
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that arises from the surface of the pleura and is associated with a history of asbestos exposure. The tumor is characterized by a strong local invasiveness and a poor response to any single modality therapy. Therefore clinical outcome of patients with MPM is poor and median survival time of untreated patients with MPM is 7 months from initial diagnosis. The Wilms Tumor Protein 1 (WT1) is a transcription factor which is highly expressed by MPM and is involved in cellular development and survival. We evaluated the role of WT1 in two human MP...
Source: Pathology Oncology Research - January 3, 2017 Category: Pathology Authors: Plönes T, Fischer M, Höhne K, Sato H, Müller-Quernheim J, Zissel G Tags: Pathol Oncol Res Source Type: research
Pitavastatin Suppresses Hyperglycemia-induced Podocyte Injury via Bone Morphogenetic Protein-7 Preservation.
CONCLUSION: Pitavastatin attenuates hyperglycemia-induced podocyte injury via Rho-Rho kinase-dependent BMP-7 preservation. This article is protected by copyright. All rights reserved.
PMID: 27997722 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - December 19, 2016 Category: Drugs & Pharmacology Authors: Ohigashi M, Kobara M, Takahashi T, Toba H, Wada T, Nakata T Tags: Clin Exp Pharmacol Physiol Source Type: research
Abstract 3012: The Snm1B/Apollo DNA nuclease functions in resolution of replication stress and maintenance of genome stability
A critical aspect of normal cellular processes is the maintenance of genomic stability. Defects in cellular responses to DNA damage can lead to an accumulation of unrepaired or misrepaired lesions and ultimately, increased genome instability. Genomic DNA is constantly damaged through exposure to exogenous agents as well as during endogenous processes, including DNA replication. Progression of the replication fork can be impaired by structural or physical blocks leading to fork stalling. If stalled forks are not properly restarted or repaired, they can collapse, leading to chromosomal damage including breaks, deletions, and...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Das, I., Mason, J., Sekiguchi, J. Tags: Molecular and Cellular Biology Source Type: research
Identification of WTAP Complex Cell Biology
Wilms' tumor 1-associating protein (WTAP) is a putative splicing regulator that is thought to be required for cell cycle progression through the stabilization of cyclin A2 mRNA and mammalian early embryo development. To further understand how WTAP acts in the context of the cellular machinery, we identified its interacting proteins in human umbilical vein endothelial cells and HeLa cells using shotgun proteomics. Here we show that WTAP forms a novel protein complex including Hakai, Virilizer homolog, KIAA0853, RBM15, the arginine/serine-rich domain-containing proteins BCLAF1 and THRAP3, and certain general splicing regulat...
Source: Journal of Biological Chemistry - November 15, 2013 Category: Chemistry Authors: Horiuchi, K., Kawamura, T., Iwanari, H., Ohashi, R., Naito, M., Kodama, T., Hamakubo, T. Tags: Cell Biology Source Type: research
The wilms tumor suppressor WT1 enhances CD95L expression and promotes activation‐induced‐cell‐death in leukemic T cells
In this study, we investigated WT‐1 expression in ten T‐ALL cell lines established from leukemia/lymphoma patients. We show that consistent with the finding in primary T‐ALL cells, most of the leukemic T‐cell lines tested do not over‐express WT1 proteins. We found that leukemic T‐cells over‐expressing WT1 protein produce higher levels of CD95L and show elevated CD95L‐mediated activation‐induced cell death compared to cells lacking or expressing low levels of WT1. Ectopic expression of WT1 in the WT1‐non‐expressing leukemic T‐cell line increases CD95L expression and elevates activation‐induced apop...
Source: International Journal of Cancer - July 7, 2013 Category: Cancer & Oncology Authors: Konstantina Bourkoula, Christoph Englert, Marco Giaisi, Rebecca Köhler, Peter H. Krammer, Min Li‐Weber Tags: Cancer Cell Biology Source Type: research
