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CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells
J Cell Mol Med. 2023 Apr 21. doi: 10.1111/jcmm.17750. Online ahead of print.ABSTRACTHuman oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased ...
Source: J Cell Mol Med - April 21, 2023 Category: Molecular Biology Authors: Chia-Yu Wu Pei-Wen Peng Ting-Yi Renn Chia-Jung Lee Tsung-Ming Chang Augusta I-Chin Wei Ju-Fang Liu Source Type: research

Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells
Chem Biol Interact. 2022 Nov 4:110254. doi: 10.1016/j.cbi.2022.110254. Online ahead of print.ABSTRACTIt is widely accepted that siRNA transfection can promote some off-target effects in the genome; however, little is known about how the cells can respond to the presence of non-viral dsRNA. In the present study, non-targeting control siRNA (NTC-siRNA) was used to evaluate its effects on the activity of pathogen and host-derived nucleic acid-associated signaling pathways such as cGAS-STING, RIG-I, MDA5 and NF-κB in A431 skin cancer cells and BJ fibroblasts. NTC-siRNA treatment promoted cytotoxicity in cancer cells. Furtherm...
Source: Chemico-Biological Interactions - November 7, 2022 Category: Molecular Biology Authors: Gabriela Betlej Dominika B łoniarz Anna Lewi ńska Maciej Wnuk Source Type: research

Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1 α-EphA2-Laminin-5γ2 network in human oral cancer
J Cell Commun Signal. 2022 Sep 5. doi: 10.1007/s12079-022-00693-z. Online ahead of print.ABSTRACTVasculogenic mimicry (VM), defined as an endothelial cell independent alternative mechanism of blood and nutrient supply by dysregulated tumor cells, is associated with poor prognosis in oral squamous cell carcinoma (OSCC). Here we aim to investigate the underlying molecular mechanism of the synergistic effect of phytochemical Lupeol and standard microtubule inhibitor Paclitaxel in reversing the hypoxia induced VM formation in OSCC. The results demonstrated that the hypoxia induced upregulation of HIF-1α led to augmentation of...
Source: Journal of Cell Communication and Signaling - September 5, 2022 Category: Molecular Biology Authors: Depanwita Saha Debarpan Mitra Neyaz Alam Sagar Sen Saunak Mitra Mustafi Pradip K Majumder Biswanath Majumder Nabendu Murmu Source Type: research

LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription
Exp Mol Med. 2022 Jun 27. doi: 10.1038/s12276-022-00791-3. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and tumor progression. However, the roles and mechanisms of lncRNAs in ESCC require further exploration. Here, in combination with a small interfering RNA (siRNA) library targeting specific lncRNAs, we performed MTS and Transwell assays to screen functional lncRNAs that were overexpressed in ESCC. TMPO-AS1 expressi...
Source: Molecular Medicine - June 27, 2022 Category: Molecular Biology Authors: Xiao-Jing Luo Ming-Ming He Jia Liu Jia-Bo Zheng Qi-Nian Wu Yan-Xing Chen Qi Meng Kong-Jia Luo Dong-Liang Chen Rui-Hua Xu Zhao-Lei Zeng Ze-Xian Liu Hui-Yan Luo Source Type: research

Farnesoid X receptor functions in cervical cancer via the p14 < sup > ARF < /sup > -mouse double minute 2-p53 pathway
CONCLUSIONS: FXR inhibits cervical cancer by upregulating the p14ARF-MDM2-p53 pathway. Activation of FXR may be a potential strategy for the treatment of cervical cancer.PMID:35347542 | DOI:10.1007/s11033-022-07201-x
Source: Molecular Biology Reports - March 29, 2022 Category: Molecular Biology Authors: Xiaohua Huang Bin Wang Huimin Shen Danmei Huang Ganggang Shi Source Type: research

Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells
CONCLUSIONS: MT2A downregulation reduced cell proliferation, migration and invasion activities. Therefore, MT2A has an important role in cell proliferation, migration and invasion in human oral SCC cells.PMID:35107738 | DOI:10.1007/s11033-022-07206-6
Source: Mol Biol Cell - February 2, 2022 Category: Molecular Biology Authors: Aline Marques Dias Ra íssa Pinheiro de Mendonça Maria Sueli da Silva Kataoka Ruy G Jaeger Jo ão de Jesus Viana Pinheiro S érgio de Melo Alves Junior Source Type: research

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