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The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
Conclusion and Perspectives The IL-6/JAK/STAT signaling cascade plays a dominant role in skeletal muscle pathophysiology. IL-6 autocrine, paracrine, and endocrine functions assign to its downstream effectors pivotal importance in skeletal muscle-wasting-associated diseases and other multiple system diseases where muscle acts in communication with other organs. Targeting the components of the JAK/STAT pathway recently emerged as a strategic approach for the treatment of inflammatory diseases and human cancer. This review highlights the opposite outcomes on muscle biology caused by the amount of local and systemic release ...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Up-regulation of receptor interaction protein 140 promotes glucolipotoxicity-induced damage in MIN6 cells.
Authors: Xue LJ, Huang Q, Zeng JE, Zhu H, Xu CY Abstract The receptor interaction protein 140 (RIP140) cofactor is a key regulator of metabolic balance, but its function in glucose- and lipid-mediated damage in islet β cells is unknown and was investigated in this study. RIP140 expression and distribution was evaluated in MIN6 cells under high glucose and lipid conditions using real-time Polymerase Chain Reaction (PCR), western blotting and confocal laser scanning microscopy. Cells were separately treated with 500 μM palmitic acid and 25 mM glucose when RIP140 expression was upregulated or downregulated, and cell...
Source: Cellular and Molecular Biology - April 13, 2018 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

The role of adrenomedullin in the pathogenesis of gastric cancer.
In this study, we examined the role of adrenomedullin in the pathogenesis of gastric cancer. Using clinical specimens and immunohistochemistry, we found that the expression levels of adrenomedullin and its receptors are inordinately elevated as compared to the adjacent non-tumor gastric tissues. We used siRNA gene silencing, in BGC-823 gastric cancer cell lines, to target adrenomedullin genes, and found that increased adrenomedullin expression results in the proliferation of tumor cells, tumor invasion, and metastasis. Furthermore, we found that under hypoxic conditions, gastric cancer BGC-823 cells exhibit higher expressi...
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pro‐IL‐16 is associated with MHC class II‐mediated negative regulation of mouse resting B cell activation through MAP kinases, NF‐κB, and Skp2‐dependent p27kip regulation
Abstract MHC class II molecules, in addition to their essential role as antigen‐presenting molecules to CD4+ T cell receptor, have a signal‐transducing role related to B cell function. We identified pro‐IL‐16 as one of the proteins associated with MHC class II‐mediated signaling in an analysis of MHC class II‐associated molecules using immunoprecipitation and proteomics data obtained from the 38B9 resting B‐cell line, and investigated the role of pro‐IL‐16 in resting B‐cell activation. We found that pro‐IL‐16, rather than mature form of IL‐16, is present in both in the cytoplasm and nucleus of res...
Source: Scandinavian Journal of Immunology - January 8, 2013 Category: Allergy & Immunology Authors: Hee‐Young Yang, Ju Kim, Sae‐Hae Kim, Chung‐Hyeon Choe, Yong‐Suk Jang Tags: Experimental Immunology Source Type: research