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Cancer: Acute Leukemia
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Total 260 results found since Jan 2013.
Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells.
CONCLUSIONS Our findings show that dysregulation of miR-9 is responsible for the development of IA via targeting MYOCD. miR-9 and its direct target, MYOCD, might novel therapeutic targets in the treatment of IA.
PMID: 27824808 [PubMed - in process]
Source: Medical Science Monitor - November 10, 2016 Category: Research Tags: Med Sci Monit Source Type: research
Acute myotube protein synthesis regulation by IL-6-related cytokines
IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the involvement of the ...
Source: AJP: Cell Physiology - November 1, 2017 Category: Cytology Authors: Gao, S., Durstine, J. L., Koh, H.-J., Carver, W. E., Frizzell, N., Carson, J. A. Tags: RESEARCH ARTICLE Source Type: research
Acute myotube protein synthesis regulation by IL-6-related cytokines.
Abstract
IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the i...
Source: Am J Physiol Cell Ph... - November 1, 2017 Category: Cytology Authors: Gao S, Durstine JL, Koh HJ, Carver WE, Frizzell N, Carson JA Tags: Am J Physiol Cell Physiol Source Type: research
SAMHD1 Is Variably Expressed in Mantle Cell Lymphoma and Correlated to SOX11 but Not to Survival
ConclusionsIn MCL the expression of SAMHD1 varies over a broad range and correlates to expression of SOX11. However, no significant difference in PFS or OS among patients receiving Ara-C containing induction chemotherapy is found in this study.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Wasik, A. M., Marin, E., Merrien, M., de Matos Rodrigues, J., Lord, M., Xagoraris, I., Christensson, B., Rassidakis, G., Jerkeman, M., Ek, S., Sander, B. Tags: 622. Lymphoma Biology-Non-Genetic Studies: Poster III Source Type: research
Modulation of FLT3 through decitabine-activated C/EBPa-PU.1 signal pathway in FLT3-ITD positive cells.
This study aimed to examine the effect of decitabine (DAC) on FLT3-ITD positive AML. In our study, we found that expression of FLT3 and its downstream targets was decreased in FLT3-ITD mutant cell lines treated with DAC. DAC treatment could increase the percentage of apoptotic cells and CD11b positive cells tested by flow cytometry and upregulate the expression of cleaved caspase3, cleaved PARP, C/EBPa and PU.1 detected by western blot. To explore the effect of increased expression of PU.1 on FLT3 protein, we transiently transfected MOLM13 and MV4-11 cells with siRNA against PU.1 and a siRNA control. In both FLT3-ITD posit...
Source: Cellular Signalling - August 30, 2019 Category: Cytology Authors: Hu X, Cai J, Zhu J, Lang W, Zhong J, Zhong H, Chen F Tags: Cell Signal Source Type: research
ZEB2 knock-down induces apoptosis in human myeloid leukemia HL-60 cells.
CONCLUSION: Our study results suggest that ZEB2 suppression in myeloid leukemia cells through apoptosis induction could be a proper therapeutic method.
PMID: 33475058 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - January 20, 2021 Category: Genetics & Stem Cells Authors: Fardi M, Mohammadi A, Baradaran B, Safaee S, Solali S Tags: Curr Gene Ther Source Type: research
Kinesin family member 2A acts as a potential prognostic marker and treatment target via interaction with PI3K/AKT and RhoA/ROCK pathways in acute myeloid leukemia
Oncol Rep. 2022 Jan;47(1):18. doi: 10.3892/or.2021.8229. Epub 2021 Nov 18.ABSTRACTKIF2A has been shown to be involved in the regulation of AML pathology, however, the mechanistic role of KIF2A in AML has not been fully identified. The present study aimed to identify the underlying mechanism of KIF2A regulation of AML cell function and chemosensitivity. A total of 58 patients with AML and 30 healthy subjects were enrolled for clinical analysis. AML cells (KG‑1 and Kasumi‑1) were transfected with KIF2A or control small interfering (si)RNA. PI3K/AKT pathway activator (740 Y‑P) and RhoA overexpression plasmid were added ...
Source: Oncology Reports - November 18, 2021 Category: Cancer & Oncology Authors: Xinglin Liang Ruixiang Xia Source Type: research
Dual Targeting of Anti-Apoptotic Proteins Enhances Chemosensitivity of the Acute Myeloid Leukemia Cells
CONCLUSIONS: Our investigation suggests that suppression of Mcl-1 and survivin by siRNA can effectually inhibit cell growth and overcome chemoresistance of AML cells. Therefore siRNAs may be an important adjuvant in chemotherapy for AML patients.PMID:35901361 | DOI:10.31557/APJCP.2022.23.7.2523
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2022 Category: Cancer & Oncology Authors: Behzad Baradaran Roya Nazmabadi Zohreh Ariyan Ebrahim Sakhinia Hadi Karami Source Type: research
