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Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Conclusion YTHDF1 impairs antitumour immunity via an m6A-p65-CXCL1/CXCR2 axis to promote CRC and serves as a therapeutic target in immune checkpoint blockade therapy.
Source: Gut - July 6, 2023 Category: Gastroenterology Authors: Bao, Y., Zhai, J., Chen, H., Wong, C. C., Liang, C., Ding, Y., Huang, D., Gou, H., Chen, D., Pan, Y., Kang, W., To, K. F., Yu, J. Tags: Open access, Gut Colon Source Type: research

Correction: Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer
Pichler M, Rodriguez-Aguayo C, Nam SY, et al. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut 2020;69:1818–31. In figure 6A a wrong panel was included in the bottom row. The correct figure 6 is below. The figure legend remains the same. In the section: siRNA therapeutics targeting FLANC leads to decreased proliferation and metastasis in vivo the paragraph should read as: ‘Regarding tumour growth related parameters, we observed a lower number of mice with bioluminescence signals in the whole mouse (figure 6A), as well as in the isolated livers (figure 6B), i...
Source: Gut - September 10, 2022 Category: Gastroenterology Tags: Miscellaneous Source Type: research

Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.
CONCLUSION: Overall, our data demonstrate the oncogenic role of circPIP5K1A-miR-1273a axis in regulation of colon cancer development, which provides a novel insights into colon cancer pathogenesis. PMID: 31558874 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 20, 2019 Category: Gastroenterology Authors: Zhang Q, Zhang C, Ma JX, Ren H, Sun Y, Xu JZ Tags: World J Gastroenterol Source Type: research

Downregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6
ConclusionsDownregulation of NR2F2-AS1 induces G1 arrest of CRC cells by downregulating CDK6.
Source: Digestive Diseases and Sciences - August 19, 2019 Category: Gastroenterology Source Type: research

Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer
ConclusionsSPOP could down-regulate MMP2 expression in CRC, and this regulation is mediated by inhibiting SP1 phosphorylation and nuclear translocation through PI3K/Akt signaling pathway. Our findings in this study provide understanding of MMP2 regulation in CRC and may also shed lights on the development of anti-CRC treatments.
Source: Digestive Diseases and Sciences - December 19, 2017 Category: Gastroenterology Source Type: research

Downregulation of LncRNA-RP11-317J10.2 promotes cell proliferation and invasion and predicts poor prognosis in colorectal cancer.
CONCLUSIONS: This study reveals a crucial role for lncRNA-RP11-317J10.2 in CRC growth and invasion via upregulation of cyclin D1 expression and suggests that expression of this lncRNA may be a potential prognostic biomarker for CRC. PMID: 29073791 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - October 28, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.
CONCLUSION: AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy. These findings could have applications in cancer management. PMID: 28596680 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 21, 2017 Category: Gastroenterology Authors: Abdel-Rahman WM, Al-Khayyal NA, Nair VA, Aravind SR, Saber-Ayad M Tags: World J Gastroenterol Source Type: research

The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/{beta}-catenin signalling pathway
Conclusions We identified PRC1 as a novel Wnt target that functions in a positive feedback loop that reinforces Wnt signalling to promote early HCC recurrence.
Source: Gut - August 8, 2016 Category: Gastroenterology Authors: Chen, J., Rajasekaran, M., Xia, H., Zhang, X., Kong, S. N., Sekar, K., Seshachalam, V. P., Deivasigamani, A., Goh, B. K. P., Ooi, L. L., Hong, W., Hui, K. M. Tags: Open access, Colon cancer, Hepatic cancer Hepatology Source Type: research

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer
Conclusions We developed a high-throughput deep sequencing approach for concomitant MSI and mutational analyses in FFPE specimens. We provided novel insights into clinically relevant alterations in MSI CRC and a rationale for targeting ERBB2/HER2 mutations in Lynch and Lynch-like CRC.
Source: Gut - July 7, 2016 Category: Gastroenterology Authors: Kloth, M., Ruesseler, V., Engel, C., Koenig, K., Peifer, M., Mariotti, E., Kuenstlinger, H., Florin, A., Rommerscheidt-Fuss, U., Koitzsch, U., Wodtke, C., Ueckeroth, F., Holzapfel, S., Aretz, S., Propping, P., Loeffler, M., Merkelbach-Bruse, S., Odenthal, Tags: Colon cancer Source Type: research

Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.
CONCLUSION: ASNS may contribute to gastric cancer tumorigenesis and may represent a novel therapeutic target for prevention or intervention of gastric cancer. PMID: 27251594 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - June 3, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling
Conclusions Our study helps to unravel the mechanism by which BCL-3 is linked to poor prognosis in colorectal cancer; we suggest that targeting BCL-3 activity represents an exciting therapeutic opportunity potentially increasing the sensitivity of tumour cells to conventional therapy.
Source: Gut - June 2, 2016 Category: Gastroenterology Authors: Urban, B. C., Collard, T. J., Eagle, C. J., Southern, S. L., Greenhough, A., Hamdollah-Zadeh, M., Ghosh, A., Poulsom, R., Paraskeva, C., Silver, A., Williams, A. C. Tags: Open access, Colon cancer Source Type: research

Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells.
CONCLUSION: ILK overexpression improved the proliferation, metastasis, and invasion ability of SW480 cells, and this effect may be mediated by the NF-κB signaling pathway. PMID: 27099440 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 20, 2016 Category: Gastroenterology Authors: Shen H, Ma JL, Zhang Y, Deng GL, Qu YL, Wu XL, He JX, Zhang S, Zeng S Tags: World J Gastroenterol Source Type: research

Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development.
Conclusions TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. Therefore, this protein may represent a novel therapeutic target for prevention or intervention of CRC. PMID: 26691157 [PubMed - in process]
Source: Scandinavian Journal of Gastroenterology - February 14, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway
Conclusions We identified a novel CRC regulatory circuit involving the miR-519-Orai1 axis, and dysfunction of this drives diverse aspects of CRC pathogenesis.
Source: Digestive Diseases and Sciences - January 20, 2016 Category: Gastroenterology Source Type: research

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