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Akt1 and Jak1 siRNA based silencing effects on the proliferation and apoptosis in head and neck squamous cell carcinoma.
In conclusion, the combination of siRNA-mediated gene-silencing strategy can be considered as a valuable and safe approach for sensitizing cancer cells to chemotherapeutic agents thus proposed further studies regarding this issue to approve some siRNA based therapeutics for using in clinic. PMID: 31348981 [PubMed - as supplied by publisher]
Source: Gene - July 22, 2019 Category: Genetics & Stem Cells Authors: Saatloo MV, Aghbali AA, Koohsoltani M, Khosroushahi AY Tags: Gene Source Type: research

Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells
ConclusionThese findings suggest that ESM1 has roles on proliferation and migration of head and neck cancer cells.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - October 11, 2017 Category: Pathology Authors: Onur Bender, Mehmet Gunduz, Sadik Cigdem, Omer Faruk Hatipoglu, Muradiye Acar, Mesut Kaya, Reidar Grenman, Esra Gunduz, Kadriye Serife Ugur Tags: Original Article Source Type: research