Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells
ConclusionThese findings suggest that ESM1 has roles on proliferation and migration of head and neck cancer cells.This article is protected by copyright. All rights reserved.
Conclusions Ultrasound elastography is helpful for the diagnosis of lymph node metastases in patients with head and neck cancer. Due to its non-invasive character, it can be used safety in combination with other radiological techniques to support or improve their diagnostic performance.
ConclusionOur results suggested that using fluorescence visualization to guide surgery has the potential to spare more normal tissue at surgical margins.
Conclusions: Using conformal treatment planning, it was desirable to keep the dose to the mandible, spinal cord, and salivary glands at an acceptable level. The quantitative plan evaluation may help us find correlations between dosimetric parameters and clinical outcome, which may lead to improve the quality of the treatment, but it requires longer follow-up and results from other studies. PMID: 29441100 [PubMed]
Publication date: Available online 1 February 2018 Source:British Journal of Oral and Maxillofacial Surgery Author(s): H. Boyes, J. Barraclough, R. Ratansi, S.N. Rogers, A. Kanatas The number of clinical trials that relate to patients with cancer of the head and neck is growing. Patient-reported outcomes, which are rarely the primary outcome, are now an important component, and in this structured review to identify and report the characteristics of the questionnaires that have been used in these trials, we summarise the findings reported. We searched several online databases using the key terms: head and neck oncology, he...
ConclusionIn patients with history of HNCA and radiation, office‐based TNE with esophageal dilation appears safe, well‐tolerated, and cost‐effective. In a small cohort, the technique has low complication rate and is feasible in an otolaryngology outpatient office setting. Level of Evidence4. Laryngoscope, 2018
This study's aim was to develop a holistic surgical follow‐up clinic for oral and oropharyngeal cancer patients were participants completed a disease‐specific health‐related quality of life tool (UWQOLv4) and item prompt list (Patient Concern Inventory) on a touchscreen computer. Information generated was used to focus the consultation on patient's identified needs and concerns. By means of a prospective non‐randomised, pre‐test post‐test design, this follow‐up clinic was evaluated using the patient enablement instrument (PEI) and patient content checklist (PCC). Feasibility was explored from the patient pers...
The aim of this study was to evaluate the clinical results of surgery for head and neck cancer (HNC) in elderly patients and to determine whether surgery for elderly HNC patients is safe and what types of surgery result in the most favourable outcomes for this age group. The cases of 637 elderly patients who were diagnosed with HNC and underwent surgical treatment were studied retrospectively. Patient demographic characteristics and treatment data were extracted from the appropriate patient records and analysed.
Radioactive colloids are routinely employed in sentinel lymph node (SLN) detection procedures [1 –5]. Indocyanine green (ICG) with near-infrared (NIR) fluorescence imaging has also been successfully used in SLN procedures [6–8]. However, minimal skin incisions were not achievable. Hybrid dyes, combining ICG and radioactive colloids, have also been used in SLN procedures [9,10]. However, the use of a hybrid dye will require market authorization and investment to elaborate the tracer. In head and neck cancers, SLN mapping using sequential injection of a radioactive colloid followed by ICG has not been described yet.
Opinion statementSecond malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5–10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarci nomas and with chronic graft-versus-host disease which is associated with squamous cell cancers. There is ...
In conclusion, modified b iweekly TPEx is of comparable efficacy with conventional TPEx and represents a well-tolerated regimen in R/M SCCHN patients. Further evaluation of this protocol in prospective clinical trials is warranted.