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Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells

ConclusionThese findings suggest that ESM1 has roles on proliferation and migration of head and neck cancer cells.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - Category: Pathology Authors: Tags: Original Article Source Type: research

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The incidence of mouth and throat cancers caused by the human papilloma virus in men has now surpassed the incidence of HPV-related cervical cancers in women.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Head and Neck Cancer Human Papillomavirus (HPV) Sexually Transmitted Diseases Throat Smoking and Tobacco Men and Boys Vaccination and Immunization Infections Source Type: news
Today, most head and neck cancer subsites, such as the larynx, hypopharynx, nasopharynx, and oropharynx, are treated with radiation therapy with or without chemotherapy as a primary treatment modality. Surgery is reserved for the salvage of recurrent tumors that occur within the head and neck in the absence of distant (ie, lung, liver) metastasis. However, unlike all other head and neck subsites, oral cancer should ideally be managed with primary surgery with the possibility of adjuvant radiation therapy with or without chemotherapy depending on the presence of certain high-risk pathologic features.
Source: Dental Clinics of North America - Category: Dentistry Authors: Source Type: research
The most important prognostic factor in predicting the outcome of oral and oropharyngeal cancer (OPC) is the stage at which it is diagnosed. Only 30% of patients are diagnosed with early-stage disease. The oral health care provider performs an important role in early diagnosis of oral cancer. The conventional oral examination consists of a visual and tactile assessment of accessible oral, and head and neck structures. Any suspicious or equivocal lesion should be reevaluated within 4  weeks. Evidence supporting the use of adjunctive devices to improve the ability to screen for and identify OPCs and oral premalignant lesions remains low.
Source: Dental Clinics of North America - Category: Dentistry Authors: Source Type: research
The objective of this programme was to indoctrinate the most vulnerable and the least tended upon; the basics of head and neck cancers via the medium of their own kins. Voluntary village health workers were educated and trained to pick up the early signs of head and neck cancers. Oral self examination was taught to them and they went to peripheral villages to screen the population. They would refer suspicious cases to tertiary healthcare centre. The population was enlightened upon the basics of preventable measures, treatment options and rehabilitation facilities for head and neck cancer patients. Knowledge, attitude and p...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
ObjectivesTo explore the incidence and treatment pattern of head and neck cancer in different age groups. DesignCohort study. SettingNetherlands Cancer Registry. ParticipantsAll new primary head and neck cancer cases diagnosed between 2010 and 2014 were included and categorised into different age groups. Main outcome measuresTumour site, stage, treatment modality, location of diagnosis and treatment. ResultsThe study population was composed of 11 558 tumours. Oral cancer was the most common primary site (31%), followed by laryngeal (25%) and oropharyngeal cancer (22%). Ninety‐six per cent of the entire study populat...
Source: Clinical Otolaryngology - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
Fear of cancer recurrence (FCR) is common among individuals treated for cancer. Explorations of how this fear is expressed within an oncology setting and responded to are currently lacking. The aim was to investigate how head and neck cancer survivors in follow‐up consultations express FCR, investigate how a healthcare professional addresses recurrence fears, and examine how survivors experience this interaction. We recorded the follow‐up consultations of those participants who have reported FCR as a concern on the Patient Concerns Inventory. We also conducted a follow‐up phone interview with the participants. We ana...
Source: European Journal of Cancer Care - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This article summarizes the current evidence that guides use of chemotherapy both in combination with radiation and as monotherapy for patients with advanced disease. It also addresses the expanding role of immunotherapy, particularly use of programmed cell death-ligand 1 inhibitors, in the treatment of advanced disease.
Source: Dental Clinics of North America - Category: Dentistry Authors: Source Type: research
ConclusionsHead and neck cancers are recurrently affected by FGFR1 amplification, with a predominance in cancers of the oral cavity. Finding only one HPV positive and FGFR1 amplified cancer argues against a causal relationship between HPV and FGFR1 amplifications.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
A stressful event may be sufficient to challenge a strongly held set of assumptions about the world and the self. In some people this may lead to post-traumatic stress disorder (PTSD) and in others to positive psychological change (PPC), whereby a person ’s reactions to the challenge are beneficial. Little research has investigated PPC in people who have had head and neck cancer (HNC). The aim of this study was to identify demographic, clinical, and psychological factors associated with PPC over time.
Source: International Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Research Paper Source Type: research
ObjectivesTo access 1) the value of further surgical resection (completion surgery) in cases with a positive intraoperative margin analysis, and 2) whether cancers that undergo completion surgery following positive intraoperative margin analysis with subsequent negative margins should be considered true margin‐negative (R0) resections in terms of adjuvant treatment planning. Study DesignRetrospective analysis of patients with primary oral cancer. MethodsOne hundred and fifty‐one patients underwent primary surgical resection of oral squamous cell carcinoma with intraoperative margin examination. In all cases for which f...
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
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