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Specialty: Drugs & Pharmacology
Cancer: Bone Cancers

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Total 22 results found since Jan 2013.

Thiram, an inhibitor of 11 ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway
CONCLUSIONS: Hydrocortisone inhibits osteosarcoma through the Wnt/β-catenin pathway. Thiram inhibits 11HSD2 enzyme activity, reducing hydrocortisone inactivation and promoting the effect of hydrocortisone through the same pathway.PMID:36978114 | PMC:PMC10045229 | DOI:10.1186/s40360-023-00655-0
Source: BMC Pharmacology and Toxicology - March 28, 2023 Category: Drugs & Pharmacology Authors: You Zhang Nanjing Li He Li Maojia Chen Wei Jiang Wenhao Guo Source Type: research

Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy
This study provides a new reference to improve the efficacy of OS clinically.
Source: Frontiers in Pharmacology - December 20, 2021 Category: Drugs & Pharmacology Source Type: research

LncRNA FOXD2-AS1 knockdown inhibits the resistance of human osteosarcoma cells to cisplatin by inhibiting miR-143 expression.
CONCLUSIONS: LncRNA FOXD2-AS1 knockdown inhibits the resistance of human osteosarcoma cells to cisplatin, promotes their apoptosis and weakens their invasion and migration abilities. The possible underlying mechanism may be related to the inhibition of miR-143 expression by lncRNA FOXD2-AS1 in drug-resistant cell lines. PMID: 33577022 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

LncRNA-TMPO-AS1 promotes apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1.
CONCLUSIONS: TMPO-AS1 can function as a diagnostic and prognostic marker for osteosarcoma. LncRNA-TMPO-AS1 can promote apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1, which is a potent treatment option for osteosarcoma. PMID: 33215415 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 22, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2
ConclusionOverall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment.
Source: Biomedicine and Pharmacotherapy - February 9, 2020 Category: Drugs & Pharmacology Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
CONCLUSION: Overall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment. PMID: 32044716 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 6, 2020 Category: Drugs & Pharmacology Authors: Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J Tags: Biomed Pharmacother Source Type: research

LncRNA NKILA inhibits invasion and migration of osteosarcoma cells via NF- κB/Snail signaling pathway.
CONCLUSIONS: NKILA was lowly expressed in osteosarcoma tissues. In addition, high expression of NKILA could suppress the migration and invasion of osteosarcoma cells by inhibiting the NF-κB/Snail signaling pathway. PMID: 31173281 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 9, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Isoliquiritigenin inhibits mouse S180 tumors with a new mechanism that regulates autophagy by GSK-3 β/TNF-α pathway.
In this study, the pharmacokinetic properties and stability of isoliquiritigenin (ILQ) in microsomes were evaluated. The data showed ILQ administrated by i.h had high absorption degree (absolute bioavailability> 90%), and strong elimination ability (average t1/2≈ 67min). ILQ in rat tissues could reach peak at 0.25h, and be detected in almost all tissues. In vitro, stability of ILQ in four species liver microsomes were rat > beagle dog > monkey > human > mouse. On the basis of pharmacokinetic (PK) profiles, mechanism of ILQ against S180 was explored. ILQ could not inhibit S180 growth directly in vitro. Howe...
Source: European Journal of Pharmacology - August 29, 2018 Category: Drugs & Pharmacology Authors: Yushan R, Ying Y, Yujun T, Jingchun Y, Dongguang L, Lihong P, Pingping W, Lili Z, Fanhui Z, Zhong L, Guimin Z, Jie L Tags: Eur J Pharmacol Source Type: research

LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein
In conclusion, this study makes clear that lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein. Overall, our study illustrates that lncRNA THOR/c-myc molecular cascade might be another potent target for retinoblastoma treatment.
Source: Biomedicine and Pharmacotherapy - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Abstract The purpose of this study was to explore the role by which the DNA-dependent protein kinase complex catalytic subunit (DNA-PKcs) influences osteosarcoma MG-63 cell apoptosis, proliferation, migration and invasion. Osteosarcoma tissues and adjacent normal tissues were obtained from 57 osteosarcoma patients. Human osteosarcoma MG-63 cells were assigned into designated groups including the blank, siRNA-negative control (NC) and siRNA-DNA-PKcs groups. RT-qPCR and Western blotting methods were employed to evaluate the mRNA and protein expressions of DNA-PKcs. A cell counting kit-8 (CCK-8) assay was performed t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 1, 2017 Category: Drugs & Pharmacology Authors: Jin PY, Lu HJ, Tang Y, Fan SH, Zhang ZF, Wang Y, Li XN, Wu DM, Lu J, Zheng YL Tags: Biomed Pharmacother Source Type: research

IL-1 β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1.
IL-1β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1. Biomed Pharmacother. 2017 Sep 15;95:1147-1155 Authors: Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q, Chen S Abstract Nowadays, the role of miRNA in tumorigenesis has been largely reported. It was found that miR-506 might be associated with tumorigenesis of various cancers. The present study was aimed to investigate the character of miR-506 and some related factors in human osteosarcoma (OS) carcinogenesis. The expression level of miR-506 was downregulated in OS compared with the normal ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2017 Category: Drugs & Pharmacology Authors: Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q, Chen S Tags: Biomed Pharmacother Source Type: research

Effects of ZEB1 on regulating osteosarcoma cells via NF- κB/iNOS.
CONCLUSIONS: Inhibition of ZEB1 can facilitate osteosarcoma cell apoptosis and inhibit cell proliferation or invasion via down-regulating NF-kB/iNOS signal pathway. PMID: 28387915 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth
SummaryTranscription factor Specificity protein  1 (Sp1) and its downstream target survivin (inhibitor of apoptosis protein), play major roles in the pathogenesis of various cancers. Ewing Sarcoma (ES) is a common soft tissue/bone tumor in adolescent and young adults. Overexpression of survivin is also linked to the aggressiveness and poor prog nosis of ES. Small molecule Tolfenamic acid (TA) inhibits Sp1 and survivin in cancer cells. In this investigation, we demonstrate a strategy to target Sp1 and survivin using TA and positive control Mithramycin A (Mit) to inhibit ES cell growth. Knock down of Sp1 using small interf...
Source: Investigational New Drugs - December 25, 2016 Category: Drugs & Pharmacology Source Type: research

Targeting miR-29 induces apoptosis of osteosarcoma MG-63 cells via regulation of TGF- β1/PUMA signal.
CONCLUSIONS: Targeting miR-29 exhibits significant in vivo and in vitro anti-tumor activities in OS through a novel mechanism resulting in inhibition of TGF-β1 expression and inducing PUMA expression. PMID: 27649654 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 23, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research