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Specialty: Biochemistry
Cancer: Carcinoma

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Total 162 results found since Jan 2013.

NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species
Acta Biochim Pol. 2023 Sep 18. doi: 10.18388/abp.2020_6580. Online ahead of print.ABSTRACTNicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is an enzyme that regulates reactive oxygen species (ROS) generation, and its function in the development of chondrosarcoma remains unclear. In the present study, we studied NOX4 expression in chondrosarcoma by immunochemical examination, and analyzed the role of NOX4 in viability and apoptosis of human chondrosarcoma cell line SW1353 using NOX4 siRNA or NOX4 inhibitor GKT137831. NOX4 level significantly increased in tumor compared to that in para-carcinoma sample. The level...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Zheng Jun Wang Lei Fang Ce Ren Wen Tao Meng Xiang Hui Qing Ci Nan Source Type: research

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA
Biomacromolecules. 2023 Jul 31. doi: 10.1021/acs.biomac.3c00424. Online ahead of print.ABSTRACTGene knockdown by siRNA offers an unrestricted choice of targets and specificity based on the principle of complementary Watson-Crick base pairing with mRNA. However, the negative charge, large molecular size, and susceptibility to enzymatic degradation of siRNA impede its successful transfection, hence limiting its potential for therapeutic use. The development of efficient and safe siRNA transfection agents is, therefore, critical for siRNA-based therapy. Herein, we developed a protein-based biodynamic polymer (biodynamer) that...
Source: Biomacromolecules - July 31, 2023 Category: Biochemistry Authors: Yun Liu Salma Ashmawy Lorenz Latta Agnes-Valencia Weiss Alexander F Kiefer Sarah Nasr Brigitta Loretz Anna K H Hirsch Sangeun Lee Claus-Michael Lehr Source Type: research

CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma
Arch Biochem Biophys. 2023 Jul 25:109701. doi: 10.1016/j.abb.2023.109701. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. Cytochrome P450 2E1 (CYP2E1) is an enzyme, primarily involved in the metabolism of xenobiotics and procarcinogens. The present study was designed to investigate the potential role of CYP2E1 triggered endoplasmic reticulum stress in the progression of HCC through inhibition of apoptosis. In vitro CYP2E1 promotes HepG2 cell migration, reduced chromatin condensation, enhanced intracellular ROS accumulation and induce cell cycle progressio...
Source: Archives of Biochemistry and Biophysics - July 27, 2023 Category: Biochemistry Authors: Sharmeen Ishteyaque Karan Singh Yadav Smriti Verma Kaveri R Washimkar Madhav Nilakanth Mugale Source Type: research

MESP1-knockdown inhibits the proliferation and epithelial mesenchymal transition of hepatocellular carcinoma and enhances the tumor-suppressive effect of 5-fluorouracil
Biochem Biophys Res Commun. 2023 May 29;670:1-11. doi: 10.1016/j.bbrc.2023.05.036. Online ahead of print.ABSTRACTPrimary liver hepatocellular carcinoma (HCC) is the third most deadly malignancy worldwide,in part, because it is often diagnosed at an advanced stage. Thus, molecular markers are needed to aid in the early diagnosis and treatment of HCC. Expression of abnormal mesoderm posterior-1 (MESP1) promotes tumorigenesis; however,its role in the regulation of HCC proliferation, apoptosis,and invasion is unknown. Here,we analyzed data in The Cancer Genome Atlas (TCGA)and Genotype Tissue Expression (GTEx) databases on the ...
Source: Biochemical and Biophysical Research communications - June 4, 2023 Category: Biochemistry Authors: Shuqin Ji Man Xu Chenyu Cai Xinyue He Source Type: research

Expression and Purification of FGFR1-Fc Fusion Protein and Its Effects on Human Lung Squamous Carcinoma
Appl Biochem Biotechnol. 2023 May 9. doi: 10.1007/s12010-023-04542-6. Online ahead of print.ABSTRACTMolecular-targeted therapies for lung squamous cell carcinoma (LSCC) are limited mainly because targetable oncogenic aberrations are absent in LSCC. Recent genomic analyses have revealed that the fibroblast growth factor (FGF) signaling pathway plays a fundamental role in LSCC progression via cancer cell proliferation and angiogenesis. In the present study, we designed, expressed, and purified a fibroblast growth factor receptor fragment (FGFR1-Fc) fusion protein using NS/0 cells. In FGF2-FGFR1 overexpressed NCI-H1703 cells,...
Source: Applied Biochemistry and Biotechnology - May 9, 2023 Category: Biochemistry Authors: Lulu Zheng Huan Liu Lingfeng Chen Xinyi You Fangyi Lv Haibing Fan Qi Hui Baohua Liu Xiaojie Wang Source Type: research

Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma
In this study, we found that SUV420H2 is overexpressed in renal cancers and that high SUV420H2 expression is associated with a poor prognosis, as evidenced by RCC RNA-seq results derived from the TCGA. SUV420H2 knockdown using siRNA led to growth suppression and cell apoptosis in the A498 cell line. Furthermore, we identified DHRS2 as a direct target of SUV420H2 in the apoptosis process through a ChIP assay with a histone 4 lysine 20 (H4K20) trimethylation antibody. Rescue experiments showed that cotreatment with siSUV420H2 and siDHRS2 attenuated cell growth suppression induced by SUV420H2 knockdown only. Additionally, tre...
Source: Biochemical and Biophysical Research communications - April 29, 2023 Category: Biochemistry Authors: Tae Young Ryu Jinkwon Lee Yunsang Kang Mi-Young Son Dae-Soo Kim Youn Su Lee Mi-Young Kim Hyun-Soo Cho Source Type: research

miR-183-5p overexpression orchestrates collective invasion in salivary adenoid cystic carcinoma through the FAT1/YAP1 signaling pathway
Biochem Biophys Res Commun. 2023 Mar 8;655:127-137. doi: 10.1016/j.bbrc.2023.03.015. Online ahead of print.ABSTRACTThe invasion of cancer cells into interstitial tissues in a cohesive unit is termed collective invasion, and it is important for the invasion and metastasis of salivary adenoid cystic carcinoma (SACC). However, the underlying mechanisms regulating SACC collective invasion are still poorly understood. Here, we found that SACC tissues exhibited remarkable FAT1 downregulation and YAP1 upregulation at the invasive front, which was closely associated with collective invasion and distant metastasis. Decreasing FAT1 ...
Source: Biochemical and Biophysical Research communications - March 19, 2023 Category: Biochemistry Authors: Bing-Jun Chen Jian Jiang Tan Li Hong-Jie Jiang Xin-Hua Liang Ya-Ling Tang Source Type: research

ANXA2 as a novel substrate of FBXW7 promoting esophageal squamous cell carcinoma via ERK phosphorylation
In conclusion, this study provided evidence that FBXW7 loss of function could promote esophageal cancer through ANXA2 overexpression, and this novel regulation pathway may be used as an efficient target for ESCC treatment.PMID:36758484 | DOI:10.1016/j.bbrc.2023.01.082
Source: Biochemical and Biophysical Research communications - February 9, 2023 Category: Biochemistry Authors: Zongfei Li Yunzhi Pan Jiayi Yao Yingyin Gao Yulan Qian Minxue Zheng Sai Ma Source Type: research

SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway
Biochem Biophys Res Commun. 2022 Nov 12;637:161-169. doi: 10.1016/j.bbrc.2022.11.015. Online ahead of print.ABSTRACTThe influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells was investigated. HCC cells were transfected with siRNA and lentivirus to achieve SOS1 knock down/overexpression and changes in RNA and protein levels analyzed by q-PCR and Western blotting (WB). Transwell assay was utilized to assess variations in cell invasion and migration in vitro and by a lung metastasis model of liver cancer in vivo. High expression of SOS1 was observed in most human liv...
Source: Biochemical and Biophysical Research communications - November 20, 2022 Category: Biochemistry Authors: Yonghe Li Yaolin Yin Yi He Kun He Jingdong Li Source Type: research

Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells
In conclusion, enhancement of ferritinophagy is an important step involved in the mechanism of Artesunate-induced ferroptosis, and ferritin heavy chain levels may contribute to the regulation of sensitivity in Artesunate-induced ferroptosis in ovarian serous carcinoma cells.PMID:35903602 | PMC:PMC9309081 | DOI:10.3164/jcbn.21-82
Source: Clinical Biochemistry - July 29, 2022 Category: Biochemistry Authors: Tiger Koike Motoki Takenaka Noriko Suzuki Yoko Ueda Minako Mori Tasuku Hirayama Hideko Nagasawa Ken-Ichirou Morishige Source Type: research