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Conditional medium of gastric cancer mesenchymal stem cells promotes PD-L1 expression in gastric cancer cells and tumor growth via upregulating VGLL4
Conclusion GCMSCs-CM promotes the expression of PD-L1 and tumor growth by upregulating VGLL4 in gastric cancer cells.PMID:35583061
Source: Cancer Control - May 18, 2022 Category: Cancer & Oncology Authors: Ying Ding Wei Zhu Qianqian Wang Bin Chen Mei Wang Yuanyuan Zhao Source Type: research

Inhibition of CCCTC Binding Factor-Programmed Cell Death Ligand 1 Axis Suppresses Emergence of Chemoresistance Induced by Gastric Cancer-Derived Mesenchymal Stem Cells
ConclusionStudy results demonstrate a mechanism where GCMSC-CM promotes GC chemoresistance by upregulating CTCF-PD-L1 and provide strong evidence in support of targeting CTCF-PD-L1 signaling as a strategy to prevent resistance in the clinic.
Source: Frontiers in Immunology - April 27, 2022 Category: Allergy & Immunology Source Type: research

Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes
BMB Rep. 2022 Jan 10:5446. Online ahead of print.ABSTRACTIncreased mRNA levels of cancer upregulated gene (CUG)2 have been detected in many different tumor tissues using Affymetrix microarray. Oncogenic capability of the CUG2 gene has been further reported. However, the mechanism by which CUG2 overexpression promotes cancer stem cell (CSC)-like phenotypes remains unknown. With recent studies showing that pyruvate kinase muscle 2 (PKM2) is overexpressed in clinical tissues from gastric, lung, and cervical cancer patients, we hypothesized that PKM2 might play an important role in CSC-like phenotypes caused by CUG2 overexpres...
Source: BMB Reports - January 10, 2022 Category: Biochemistry Authors: Natpaphan Yawut Sirichat Kaowinn Il-Rae Cho Phatcharaphon Budluang Seonghye Kim Suhkmann Kim So Eun Youn Sang Seok Koh Young-Hwa Chung Source Type: research

Responses of porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses
Cell Signal. 2021 May 17:110047. doi: 10.1016/j.cellsig.2021.110047. Online ahead of print.ABSTRACTThe WNT (Wingless and Int-1) proteins play a role in stem cell development and cell differentiation. Mutations in the WNT proteins lead to the development of various tumours, including gastric tumours. Porcupine (PORCN) is a palmitoyltransferase and Wntless (WLS) is a chaperone protein that modify and fold the WNT proteins respectively and are involved in their proper secretion and binding to the frizzled (FZD) receptor and the lipoprotein receptor-related protein 5 or 6 (LRP5/6). We investigated how modifications of PORCN an...
Source: Cellular Signalling - May 20, 2021 Category: Cytology Authors: Rowida Mohamed Catherine Kennedy William G Willmore Source Type: research

Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Abstract The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development of breast cancer, lung cancer, neuroblastoma, colorectal cancer, leukemia, cervical cancer, gallbladder cancer, gastric cancer, kidney cancer, Ewing's sarcoma, esophageal cancer, and head and neck cancer. Overexpression of these two factors has been associated with increased processes involved in carcinogenesis, such as invasion, migration, epithelial-mesenchymal transition (EMT), angiog...
Source: Cytokine - September 6, 2020 Category: Molecular Biology Authors: Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM Tags: Cytokine Source Type: research

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