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The impact of PIK3R1 mutations and insulin-PI3K-glycolytic pathway regulation in prostate cancer
CONCLUSIONS: Our findings describe a novel genomic feature in metastatic prostate cancer and suggest that PIK3R1 alteration may be a key event for insulin-PI3K-glycolytic pathway regulation in prostate cancer.PMID:35670774 | DOI:10.1158/1078-0432.CCR-21-4272
Source: Clinical Genitourinary Cancer - June 7, 2022 Category: Cancer & Oncology Authors: Goutam Chakraborty Subhiksha Nandakumar Rahim Hirani Bastien Nguyen Konrad H Stopsack Christoph Kreitzer Sai Harisha Rajanala Romina Ghale Ying Z Mazzu Naga Vara Kishore Pillarsetty Gwo-Shu Mary Lee Howard I Scher Michael J Morris Tiffany Traina Pedram Ra Source Type: research

Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen. Materials and Methods B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research

Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin
Conclusion: Our results provide novel evidence that HDGF interacts with DDX5 and promotes the progression of EC through the induction of β-catenin. Introduction Endometrial cancer (EC) comprises the most common malignancy involving the female genital tract and the fourth most common malignancy in women after breast, lung, and colorectal cancers (1). In 2012, approximately 320,000 new cases of EC were diagnosed worldwide and the incidence is increasing (2). Currently, endometrial carcinogenesis is thought to be a multi-step process involving the coordinated interaction of hormonal regulation, gene mutation, ad...
Source: Frontiers in Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

The role of adrenomedullin in the pathogenesis of gastric cancer.
In this study, we examined the role of adrenomedullin in the pathogenesis of gastric cancer. Using clinical specimens and immunohistochemistry, we found that the expression levels of adrenomedullin and its receptors are inordinately elevated as compared to the adjacent non-tumor gastric tissues. We used siRNA gene silencing, in BGC-823 gastric cancer cell lines, to target adrenomedullin genes, and found that increased adrenomedullin expression results in the proliferation of tumor cells, tumor invasion, and metastasis. Furthermore, we found that under hypoxic conditions, gastric cancer BGC-823 cells exhibit higher expressi...
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The role of MALAT-1 in the invasion and metastasis of gastric cancer.
CONCLUSIONS: MALAT-1 may promote the migration and invasion of GC cells in part by regulating EMT. PMID: 28276823 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - March 11, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.
CONCLUSION: ASNS may contribute to gastric cancer tumorigenesis and may represent a novel therapeutic target for prevention or intervention of gastric cancer. PMID: 27251594 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - June 3, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research