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Erratum to: Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment
J Zhejiang Univ Sci B. 2022 Feb 15;23(2):171-172. doi: 10.1631/jzus.B19e0468.ABSTRACTThe online version of the original article can be found at https://doi.org/10.1631/jzus.B1900468 The original version of this article (Liu et al., 2020) unfortunately contained some mistakes. 1. Figs. 7c and 7d in p.229 were incorrect. The upper left and bottom left pictures in Fig. 7c were accidentally duplicated with the pictures at the same position of Fig. 1a. The upper right and bottom right pictures were mistakenly placed in Fig. 7c. Therefore, the calculation results in Fig. 7d were also mistaken. The correct versions should be as f...
Source: J Zhejiang Univ Sci ... - February 21, 2022 Category: Science Authors: Xuan Liu Xueqing Zhou Xuwei Shang Li Wang Yi Li Hong Yuan Fuqiang Hu Source Type: research

Therapeutic siRNA: State-of-the-Art and Future Perspectives
This article reviews the knowledge on siRNA design and chemical modification, as well as issues related to siRNA delivery that may be addressed using different delivery systems. Details on the mode of action and clinical status of the various siRNA therapeutics are provided, before giving an outlook on issues regarding the future of siRNA drugs and on their potential as one emerging standard modality in pharmacotherapy. Notably, this may also cover otherwise un-druggable diseases, the definition of non-coding RNAs as targets, and novel concepts of personalized and combination treatment regimens.
Source: BioDrugs - August 23, 2022 Category: Drugs & Pharmacology Source Type: research

A cathepsin B/GSH dual-responsive fluorinated peptide for effective siRNA delivery to cancer cells
Bioorg Chem. 2023 Mar 20;135:106485. doi: 10.1016/j.bioorg.2023.106485. Online ahead of print.ABSTRACTSmall interfering RNA (siRNA) can be exploited to silence specific genes associated with cancer development, and successful siRNA therapy is highly dependent on the efficiency of the siRNA delivery vector. Herein, a well-designed novel redox- and enzyme-responsive fluorinated polyarginine (PFC-PR) was developed to be used as an anti-cancer siRNA carrier. The multiple guanidine groups could provide positive charges and bind with siRNA efficiently, and further fluorination modification enhanced the interaction with siRNA, re...
Source: Bioorganic Chemistry - March 24, 2023 Category: Chemistry Authors: Zhen Shi Yuhan Yang Ziyang Guo Shun Feng Yu Wan Source Type: research

Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect against growth and tumor immune escape in colorectal cancer
CONCLUSION: Exosomes containing PD-L1 siRNA and CTLA-4 siRNA suppressed CRC progression and enhanced tumor immune responses.PMID:37217085 | DOI:10.1016/j.ygeno.2023.110646
Source: Genomics - May 22, 2023 Category: Genetics & Stem Cells Authors: Jian Li Yuxiang Chen Mingmei Liao Shuyi Yu Binwen Yuan Zeming Jia Lin Zhou Yaping Tang Source Type: research

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine ‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration.
Positron emission tomography is used to study the fate of polyplexes formed by siRNA and modified polyamines. Polyplexes are prepared with either radiolabeled siRNA or radiolabeled polyamines. By comparing biodistribution patterns of labeled siRNA and labeled polyamines conclusions are driven on the stability of the polyplexes in vivo. AbstractPolyamine-based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or ...
Source: Small - August 4, 2023 Category: Nanotechnology Authors: Cristina Simo, Cristian Salvador, Patrizia Andreozzi, Vanessa Gomez ‐Vallejo, Gabriela Romero, Damien Dupin, Jordi Llop, Sergio E. Moya Tags: Research Article Source Type: research

Effect of the combination of cationic lipid and phospholipid on gene-knockdown using siRNA lipoplexes in breast tumor cells and mouse lungs
Mol Med Rep. 2023 Oct;28(4):180. doi: 10.3892/mmr.2023.13067. Epub 2023 Aug 18.ABSTRACTPreviously, using three types of cationic lipids, the effect of phospholipids in liposomal formulations on gene-knockdown efficacy was determined after in vitro and in vivo transfection with small interfering RNA (siRNA)/cationic liposome complexes (siRNA lipoplexes) containing various cationic lipids and phospholipids. In the present study, six other types of cationic lipids, namely N,N-dimethyl-N-tetradecyltetradecan-1-aminium bromide, N-hexadecyl-N,N-dimethylhexadecan-1-aminium bromide (DC-1-16), 2-[bis{2-(tetradecanoyloxy)ethyl}amino...
Source: Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Yoshiyuki Hattori Min Tang Aya Aoki Momoka Ezaki Hana Sakai Kei-Ichi Ozaki Source Type: research