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Procedure: Liver Transplant
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Total 13440 results found since Jan 2013.
Correction: Liver Transplantation After Hepatic Artery Infusion Pump Therapy: Single-Center Experience and Technical Considerations
Ann Surg Oncol. 2023 Sep 22. doi: 10.1245/s10434-023-14351-0. Online ahead of print.NO ABSTRACTPMID:37737969 | DOI:10.1245/s10434-023-14351-0
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Angela L Hill Darren R Cullinan Ola Ahmed Neeta Vachharajani Meranda D Scherer Franklin Olumba Adeel S Khan William C Chapman Majella B Doyle Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
Euro Surveill. 2023 Sep;28(38). doi: 10.2807/1560-7917.ES.2023.28.38.2300171.ABSTRACTOn 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary Task Force (TF) for rapid detection of probable cases and response. The experts of the TF came from various disciplines: clinicians, laboratory experts, epidemiologists, public health experts an...
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Berta Grau-Pujol Jo ão Vieira Martins Isabel Goncalves Fernanda Rodrigues Rita de Sousa Dina Oliveira Joana Bettencourt Diana Mendes In ês Mateus de Cunha Sara Pocinho Ana Firme Benvinda Estela Dos Santos Andr é Peralta Santos Maria Jo ão Albuquerque Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Non-coding RNAs: The potential biomarker or therapeutic target in hepatic ischemia-reperfusion injury
World J Gastroenterol. 2023 Sep 7;29(33):4927-4941. doi: 10.3748/wjg.v29.i33.4927.ABSTRACTHepatic ischemia-reperfusion injury (HIRI) is the major complication of liver surgery and liver transplantation, that may increase the postoperative morbidity, mortality, tumor progression, and metastasis. The underlying mechanisms have been extensively investigated in recent years. Among these, oxidative stress, inflammatory responses, immunoreactions, and cell death are the most studied. Non-coding RNAs (ncRNAs) are defined as the RNAs that do not encode proteins, but can regulate gene expressions. In recent years, ncRNAs have emerg...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Jia-Li Shao Li-Juan Wang Ji Xiao Jin-Feng Yang Source Type: research
Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.ABSTRACTHepatitis due to hepatitis B virus (HBV) reactivation can be serious and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving chemotherapy, especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation. Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver. The expression of these silent genomes is controlled by the immune system. Suppression or ablation of immune cells, most imp...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law Source Type: research
Non-coding RNAs: The potential biomarker or therapeutic target in hepatic ischemia-reperfusion injury
World J Gastroenterol. 2023 Sep 7;29(33):4927-4941. doi: 10.3748/wjg.v29.i33.4927.ABSTRACTHepatic ischemia-reperfusion injury (HIRI) is the major complication of liver surgery and liver transplantation, that may increase the postoperative morbidity, mortality, tumor progression, and metastasis. The underlying mechanisms have been extensively investigated in recent years. Among these, oxidative stress, inflammatory responses, immunoreactions, and cell death are the most studied. Non-coding RNAs (ncRNAs) are defined as the RNAs that do not encode proteins, but can regulate gene expressions. In recent years, ncRNAs have emerg...
Source: World Journal of Gastroenterology - September 21, 2023 Category: Gastroenterology Authors: Jia-Li Shao Li-Juan Wang Ji Xiao Jin-Feng Yang Source Type: research
Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.ABSTRACTHepatitis due to hepatitis B virus (HBV) reactivation can be serious and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving chemotherapy, especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation. Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver. The expression of these silent genomes is controlled by the immune system. Suppression or ablation of immune cells, most imp...
Source: World Journal of Gastroenterology - September 21, 2023 Category: Gastroenterology Authors: Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
Pain management for liver transplant recipients
We present current evidence-based literature that reviews optimal pain management strategies for this challenging patient demographic.RECENT FINDINGS: Multiple studies have shown that thoracic epidurals provide superior pain control in open hepatic resections. Recent data suggests thoracic epidurals may be safely considered in select liver transplant recipients with normal preoperative coagulation status; however, this evidence is limited, and further studies are needed. When the risks of coagulopathy prohibit epidural placement, truncal blocks such as transversus abdominis plane blocks or quadratus lumborum blocks and abd...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Simrat Kaur Patrick Henthorn Adrian Hendrickse Source Type: research
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions
Curr Opin Organ Transplant. 2023 Sep 19. doi: 10.1097/MOT.0000000000001101. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).RECENT FINDINGS: Contemporary viscoelastic coagulation monitoring systems have demonstrated advantages over conventional coagulation tests in assessing the patient's coagu...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Kofi B Vandyck Walter Rusin Samhati Mondal Kenichi A Tanaka Source Type: research
Pain management for liver transplant recipients
We present current evidence-based literature that reviews optimal pain management strategies for this challenging patient demographic.RECENT FINDINGS: Multiple studies have shown that thoracic epidurals provide superior pain control in open hepatic resections. Recent data suggests thoracic epidurals may be safely considered in select liver transplant recipients with normal preoperative coagulation status; however, this evidence is limited, and further studies are needed. When the risks of coagulopathy prohibit epidural placement, truncal blocks such as transversus abdominis plane blocks or quadratus lumborum blocks and abd...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Simrat Kaur Patrick Henthorn Adrian Hendrickse Source Type: research
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions
Curr Opin Organ Transplant. 2023 Sep 19. doi: 10.1097/MOT.0000000000001101. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).RECENT FINDINGS: Contemporary viscoelastic coagulation monitoring systems have demonstrated advantages over conventional coagulation tests in assessing the patient's coagu...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Kofi B Vandyck Walter Rusin Samhati Mondal Kenichi A Tanaka Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
Donor bile duct evaluation with magnetic resonance cholangiography in living-donor liver transplantation: a novel anatomical classification for predicting surgical techniques
CONCLUSION: The proposed classification in this study includes all anatomical variations. This inclusive classification accurately predicts the surgical technique for LDLT.PMID:37724709 | DOI:10.4274/dir.2023.232321
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - September 19, 2023 Category: Radiology Authors: Afak Durur Karakaya Cemal Ayd ın Gündoğmuş Turan Kanmaz Cihan Karata ş Samet Kapakin Source Type: research
