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Drug: Metformin
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AUTH/2793/9/15 - Clinical pharmacist v AstraZenecaCase number:AUTH/2793/9/15Case ref:Clinical pharmacist v AstraZenecaDescription:Identifying patients suitable for Forxiga treatment and failing to provide an accurate response to the PanelNo breach:No breaches Clauses 2 and 7.2Breach:Breaches Clauses 3.2, 7.2 and 9.1. Corrective statement and public reprimand.Appeal:No appealReview:Published in the May 2016 ReviewReceived:10/09/2015Completed:17/03/20162793Case Summary:A clinical pharmacist complained about an AstraZeneca leavepiece about how to create a clinical system search to identify patients suitable for tr...
Source: PharmaGossip - September 27, 2016 Category: Pharmaceuticals Authors: insider Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In search of the mechanisms of metformin in cancer
In search of the mechanisms of metformin in cancer, Published online: 26 September 2018; doi:10.1038/s41574-018-0104-3In search of the mechanisms of metformin in cancer
Source: Nature Reviews Endocrinology - September 26, 2018 Category: Endocrinology Authors: Alan Morris Source Type: research
Endometrial function in women with polycystic ovary syndrome: a comprehensive review
AbstractBACKGROUNDPolycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. An endometrial component has been suggested to contribute to subfertility and poor reproductive outcomes in affected women.OBJECTIVE AND RATIONALEThe aim of this review was to determine whether there is sufficient evidence to support that endometrial function is altered in women with PCOS, whether clinical features of PCOS affect the endometrium, and whether there are evidence-based interventions to improve endometrial dysfunction in PCOS women.SEARCH METHODSAn extensive literature search was performed from 1970 up to Ju...
Source: Human Reproduction Update - December 10, 2020 Category: OBGYN Source Type: research
Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database
rman
& S J Freedland
Source: Prostate Cancer and Prostatic Diseases - October 8, 2013 Category: Urology & Nephrology Authors: E H AllottM R AbernL GerberC J KetoW J AronsonM K TerrisC J KaneC L AmlingM R CooperbergP G MoormanS J Freedland Tags: metformin diabetes biochemical recurrence outcomes Source Type: research
Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS: A systematic review
Publication date: June 2014 Source:Middle East Fertility Society Journal, Volume 19, Issue 2 Author(s): Sabraj Gill , Ailsa Gemmell , Rebecca Colleran , Nurhazwani Bt Zanuri , Helen O’Brien , Amudha Poobalan Background Polycystic Ovary Syndrome (PCOS) is clinically associated with infertility. Many women are resistant to Clomiphene Citrate and the addition of insulin sensitisers may help to overcome this challenge. Objective This review aims to assess if Metformin added to Clomiphene Citrate improves pregnancy outcomes in patients with PCOS and are resistant to Clomiphene Citrate. Search strategy A systematic search ...
Source: Middle East Fertility Society Journal - November 3, 2014 Category: Reproduction Medicine Source Type: research
Using Age-Related Gene Expression Changes to Search for Drugs to Slow Aging
In this study, using gene expression data for human brain ageing, we aimed to discover not only new pro-longevity drugs but also those that can improve health during ageing. The biological processes showing a change in expression include pathways related to synaptic and cognitive functions as well as proteostasis, suggesting gene expression changes in the ageing brain could be used as a surrogate to find drugs to target detrimental effects.
Using multiple gene expression datasets from brain tissue, taken from patients of different ages, we first identified the expression changes that characterise ageing. Then, we c...
Source: Fight Aging! - July 2, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Systematic Review of Cost-Effectiveness of Sodium-Glucose Cotransporter Inhibitors for Type 2 Diabetes
The objective of this review was to evaluate the most updated evidence that examined the cost-effectiveness of SGLT2i for T2DM.Recent FindingsWe systematically searched Medline (PubMed), EMBASE, and Web of Science for eligible articles from January 1, 2011, to October 31, 2019, using combinations of search words. A supplementary search using reference lists of eligible articles and other review articles was also performed. A multistage screening process was carried out with duplicates removal, abstract screening, and full-text reading to confirm eligibility. Two reviewers independently screened the eligible articles and as...
Source: Current Diabetes Reports - March 11, 2020 Category: Endocrinology Source Type: research
Search list of recalled metformin products
Source: FDA Center for Drug Evaluation and Research - What's New - July 13, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Impact of Chinese Herbal Medicine on Glucolipid Metabolic Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
CONCLUSION: Compared with the placebo group, Chinese herbal medicine had positive effects on glucolipid metabolism in women with PCOS. Chinese herbal medicine had a positive effect on lipid metabolism when the control group was metformin, but no effect on glucose metabolism. These findings need to be verified in high-quality, large-sample, randomized controlled trials in the future.PMID:36212945 | PMC:PMC9546672 | DOI:10.1155/2022/3245663
Source: Evidence-based Complementary and Alternative Medicine - October 10, 2022 Category: Complementary Medicine Authors: Jie Li Ruqun Zheng Zixin Lin Fangyuan Hu Ying Lin Guomei Zeng Jieni Fang Yingyan Shen Huiyan Tan Mei Han Juan Li Source Type: research
Metformin is a Novel Suppressor for Vimentin in Human Gastric Cancer Cell Line
In this study, AGS gastric cancer cells were treated with metformin and vimentin-specific siRNA (vim-siRNA) for 48 h. The impact of metformin and vim-siRNA on vimentin downregulation in AGS cells were analyzed by quantitative PCR and Western blot. Following treatment with metformin and vim-siRNA, cell motility, migration and invasion abilities of AGS cells were also analyzed. The results showed that inhibition of vimentin due to metformin was comparable with the vim-siRNA. Furthermore, wound-healing and invasion assays showed a significant decrease in migration and invasion of AGS cells following metformin and vim-siRNA tr...
Source: Molecular Medicine - February 18, 2022 Category: Molecular Biology Authors: Shiva Valaee Mehdi Shamsara Mohammad Mehdi Yaghoobi Source Type: research
