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Total 22557 results found since Jan 2013.

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/ β-catenin signalling pathway
CONCLUSION: This study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/β-catenin signalling pathway under ischemic conditions.PMID:34857032 | DOI:10.1186/s40779-021-00356-x
Source: Cell Research - December 3, 2021 Category: Cytology Authors: Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Source Type: research

Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid‐Associated Osteonecrosis in Rabbits
This study was designed to prove our hypothesis that blocking VEGF‐Src signaling pathway by specific Src siRNA was able to prevent destructive repair in a SAON rabbit model. Destructive repair in SAON was induced in rabbits. At 2, 4, 6 weeks after SAON induction, VEGF, anti‐VEGF, Src siRNA, Src siRNA + VEGF, control siRNA and saline were intramedullary injected into proximal femora for each group, respectively. Vascularization and permeability were quantified by dynamic contrast‐enhanced (DCE) MRI. At week 6 after SAON induction, proximal femora were dissected for micro‐CT‐based trabecular architecture with f...
Source: Journal of Bone and Mineral Research - April 27, 2015 Category: Orthopaedics Authors: Li‐zhen Zheng, Hui‐juan Cao, Shi‐hui Chen, Tao Tang, Wei‐min Fu, Le Huang, Dick Ho Kiu Chow, Yi‐xiang Wang, James Francis Griffith, Wei He, Hong Zhou, De‐wei Zhao, Ge Zhang, Xin‐luan Wang, Ling Qin Tags: Original Article Source Type: research

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood –brain barrier injury through the Wnt/β-catenin signalling pathway
ConclusionThis study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/ β-catenin signalling pathway under ischemic conditions.
Source: Military Medical Research - December 3, 2021 Category: International Medicine & Public Health Source Type: research

Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia
CONCLUSIONS: We identified a small number of studies that met our inclusion criteria, and these differed in the controls they used and how they measured important outcomes. Limited data from these trials provide very low- to low-certainty evidence, and we are unable to draw conclusions to support the use of local intramuscular transplantation of BMMNC for improving clinical outcomes in people with CLI. Evidence from larger RCTs is needed in order to provide adequate statistical power to assess the role of this procedure.PMID:35802393 | PMC:PMC9266992 | DOI:10.1002/14651858.CD008347.pub4
Source: Cochrane Database of Systematic Reviews - July 8, 2022 Category: General Medicine Authors: Bobak Moazzami Zinat Mohammadpour Zohyra E Zabala Ermia Farokhi Aria Roohi Elena Dolmatova Kasra Moazzami Source Type: research

A coronary artery segmentation method based on region growing with variable sector search area.
CONCLUSIONS: Quantitative evaluations are conducted on coronary angiography and the results show that the proposed method achieves a higher DSC ratio and a more reliable sensitivity ratio. PMID: 32364179 [PubMed - as supplied by publisher]
Source: Technology and Health Care - April 21, 2020 Category: Medical Devices Authors: Ma G, Yang J, Zhao H Tags: Technol Health Care Source Type: research

Active testing search for point cloud matching.
We present a general approach for solving the point-cloud matching problem for the case of mildly nonlinear transformations. Our method quickly finds a coarse approximation of the solution by exploring a reduced set of partial matches using an approach to which we refer to as Active Testing Search (ATS). We apply the method to registration of graph structures by branching point matching. It is based solely on the geometric position of the points, no additional information is used nor the knowledge of an initial alignment. In the second stage, we use dynamic programming to refine the solution. We tested our algorithm on ang...
Source: Inf Process Med Imaging - December 2, 2014 Category: Radiology Tags: Inf Process Med Imaging Source Type: research

Finite Element Analysis in Asymptomatic, Symptomatic, and Ruptured Abdominal Aortic Aneurysms: In Search of New Rupture Risk Predictors.
CONCLUSIONS: From different FEA derived parameters, PWRI distinguishes most precisely between asymptomatic and symptomatic AAA. If elevated, this value may represent a negative prognostic factor for asymptomatic AAAs. PMID: 25542592 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - December 23, 2014 Category: Surgery Authors: Erhart P, Hyhlik-Dürr A, Geisbüsch P, Kotelis D, Müller-Eschner M, Gasser TC, von Tengg-Kobligk H, Böckler D Tags: Eur J Vasc Endovasc Surg Source Type: research

CCC Update 011
Updates to the LITFL Critical Care Compendium are coming thick and fast at the moment. Here’s a quick summary as these entries don’t appear in the LITFL blog feed, and you otherwise need to search for them using search keywords in the CCC table, by googling “litfl ccc searchterm” or by searching GoogleFOAM. Remember, constructive feedback is the fuel that LITFL runs on, hit us with it! Here’s what is new in the CCC since CCC Update 010: Cerebral venous thrombosis This condition reared its head in the last round of FCICM exam vivas I believe — and it wouldn’t surprise me if it...
Source: Life in the Fast Lane - August 15, 2015 Category: Emergency Medicine Authors: Chris Nickson Tags: Critical Care Compendium Education Emergency Medicine Intensive Care CCC cerebral venous thrombosis early mobilistation extremity trauma ICU acquired weakness MODS Source Type: blogs

Indocyanine Green Angiography in Breast Reconstruction: Utility, Limitations, and Search for Standardization
Conclusions: ICGA can reduce postoperative tissue loss and aid in intraoperative flap design and inset. Despite the benefits of ICGA, its technical use and interpretation have yet to be standardized, limiting its widespread acceptance.
Source: Plastic and Reconstructive Surgery Global Open - March 1, 2020 Category: Cosmetic Surgery Tags: Original Articles Source Type: research

Non-invasive diagnostic procedures for suspected CHD: search reveals informative evidence
(Institute for Quality and Efficiency in Health Care) Non-invasive diagnostic procedures for suspected CHD: search reveals informative evidence Informative study results are available on diagnostic procedures using computed tomography angiography (CTA) and magnetic resonance imaging (MRI) for suspected coronary heart disease (CHD).
Source: EurekAlert! - Medicine and Health - July 8, 2020 Category: International Medicine & Public Health Source Type: news

OCTA Biomarker Search in Patients with nAMD: Influence of Retinal Fluid on Time-Dependent Biomarker Response
CONCLUSIONS: OCTA-based parameters VA, TVL, TNJ, and MNVarea show a strong response to anti-VEGF therapy over time, independent of the presence of IRF, SRF or RT. We conclude that the above listed OCTA parameters could contribute to our understanding of MNV biology and to guide individualized treatment in the future.TRIAL REGISTRY: The authors confirm that all ongoing and related trials are registered. ClinicalTrials.gov Number: NCT02521142.PMID:36891909 | DOI:10.1080/02713683.2023.2184318
Source: Current Eye Research - March 9, 2023 Category: Opthalmology Authors: Reinhard Told Adrian Reumueller Markus Schranz Jonas Brugger G ünther Weigert Gregor Sebastian Reiter Stefan Sacu Ursula Schmidt-Erfurth Source Type: research