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Specialty: Respiratory Medicine

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Total 170 results found since Jan 2013.

A narrative review of interstitial lung disease in anti-synthetase syndrome: a clinical approach
J Thorac Dis. 2021 Sep;13(9):5556-5571. doi: 10.21037/jtd-20-3328.ABSTRACTAnti-synthetase syndrome (AS) is a rare autoimmune disorder characterized by the presence of aminoacyl-transfer RNA synthetase antibodies in conjunction with clinical features such as interstitial lung disease (ILD), Raynaud's phenomenon, nonerosive arthritis, and myopathy. AS distinguishes itself from other inflammatory myopathies by its significant lung involvement and rapidly progressive interstitial lung disease (AS-ILD), therefore the management of AS-ILD requires careful clinical, serologic and radiologic assessment. Glucocorticoids are conside...
Source: Journal of Thoracic Disease - October 18, 2021 Category: Respiratory Medicine Authors: Naina Sawal Sanjay Mukhopadhyay Sheetal Rayancha Alastair Moore Puneet Garcha Anupam Kumar Viren Kaul Source Type: research

Intermittent Abdominal Pressure Ventilation: An Alternative for Respiratory Support
Can Respir J. 2021 Aug 23;2021:5554765. doi: 10.1155/2021/5554765. eCollection 2021.ABSTRACTIntermittent abdominal pressure ventilation is a positive pressure ventilation technique that works with abdominal compressions. It has been known since 1938; however, for many years, it was out of production. In recent years, a new device has been produced that has captured the attention to this old respiratory support technique. We considered eight patients with respiratory failure secondary to a neuromuscular disease (congenital myopathy, Duchenne dystrophy, and amyotrophic lateral sclerosis) intolerant to daytime noninvasive ven...
Source: Respiratory Care - September 2, 2021 Category: Respiratory Medicine Authors: Giuseppe Fiorentino Anna Annunziata Antonietta Coppola Antonella Marotta Francesca Simioli Pasquale Imitazione Maurizia Lanza Rosa Cauteruccio Antonio M Esquinas Source Type: research

Glucocorticoid-Induced Myopathy in People with Asthma: A Systematic Review
Conclusions: There were limited studies and inconsistent results on glucocorticoid-induced myopathy in people with asthma, and its association with the characteristics of glucocorticoids use. We recommended future studies should use a commonly accepted operational definition of myopathy, utilize a cohort study design, measure the cumulative dosage of glucocorticoids, and integrate possible confounding factors in the analysis.PMID:33951991 | DOI:10.1080/02770903.2021.1926488
Source: Journal of Asthma - May 6, 2021 Category: Respiratory Medicine Authors: Kenneth Wu Anna Michalski Daniel Cortes Dmitry Rozenberg Sunita Mathur Source Type: research

Myositis-specific antibodies identify a distinct interstitial pneumonia with autoimmune features phenotype
Interstitial pneumonia with autoimmune features (IPAF) characterises individuals with interstitial lung disease (ILD) and features of connective tissue disease (CTD) who fail to satisfy CTD criteria. Inclusion of myositis-specific antibodies (MSAs) in the IPAF criteria has generated controversy, as these patients also meet proposed criteria for an antisynthetase syndrome. Whether MSAs and myositis-associated antibodies (MAA) identify phenotypically distinct IPAF subgroups remains unclear. A multicentre, retrospective investigation was conducted to assess clinical features and outcomes in patients meeting IPAF criteria stra...
Source: European Respiratory Journal - December 3, 2020 Category: Respiratory Medicine Authors: Graham, J., Bauer Ventura, I., Newton, C. A., Lee, C., Boctor, N., Vu Pugashetti, J., Cutting, C., Joerns, E., Sandhu, H., Chung, J. H., Garcia, C. K., Kadoch, M., Noth, I., Adegunsoye, A., Strek, M. E., Oldham, J. M. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung disease Source Type: research

Respiratory failure and sleep-disordered breathing in late-onset Pompe disease: a narrative review.
Authors: Shah NM, Sharma L, Ganeshamoorthy S, Kaltsakas G Abstract Late-onset Pompe disease (LOPD) is a rare autosomal recessive glycogen storage disease that results in accumulation of glycogen in muscle cells causing muscular weakness. It causes a progressive proximal myopathy, accompanied by respiratory muscle weakness, which can lead to ventilatory failure. In untreated LOPD, the most common cause of death is respiratory failure. Patients suffering from respiratory compromise may present with symptoms of sleep-disordered breathing (SDB) before overt signs of respiratory failure. Diaphragm weakness leads to noct...
Source: Journal of Thoracic Disease - November 22, 2020 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Antisynthetase syndrome related interstitial lung disease may have a better treatment response than other forms of Idiopathic Inflammatory Myopathies: a multi-national study
Conclusions: ASS related ILD had a better treatment response than other forms of IIM in our cohort. ANA is often negative.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Enghelmayer, J. I., Vivero, F., Leiva Aguero, S., Quadrelli, S., Lancelloti, D., Campins, F., Sebastiani, J., Malfante, P., Gandara, E., Basso, V., Romiti, M., Gaser, A., Sacnun, M., Zenon, F., Gomez, R., Aruj, P., Pacello, F., Naval, N., Moyano, V., Mari Tags: ILD / DPLD of known origin Source Type: research

Non-invasive ventilation post lung transplantation in a home setting
Conclusion: NIV seems to be a valuable treatment option, specially for CLAD, with favorable tolerability and security profiles.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Magalhaes, A. R., Moreira, I., Caldeira, V., Sa, T., Borba, A., Calvinho, P., Semedo, L., Cardoso, J., Fragata, J. Tags: Rehabilitation and chronic care Source Type: research

Urine Titin N-fragment as a Biomarker of Muscle Injury for Critical Illness Myopathy.
PMID: 33030965 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 8, 2020 Category: Respiratory Medicine Authors: Nakano H, Hashimoto H, Mochizuki M, Naraba H, Takahashi Y, Sonoo T, Matsubara T, Yamakawa K, Nakamura K Tags: Am J Respir Crit Care Med Source Type: research

Recovery from hypoxemia and Hypercapnia following noninvasive pressure support ventilation in a patient with statin-associated necrotizing myopathy: a case report
Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report ...
Source: BMC Pulmonary Medicine - June 3, 2020 Category: Respiratory Medicine Authors: Yuriko Yamamura, Yoshinori Matsumoto, Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Toru Yamashita, Masahiro Yamamura, Ken-Ei Sada, Koji Abe and Jun Wada Tags: Case report Source Type: research

Does cystic fibrosis impact skeletal muscles and diaphragm function?
Conclusion: CF patients had lower muscle thicknesses and handgrip strength than controls. Patients taking oral nutritional support and those with pancreatic insufficiency, had lower rectus femoris thickness and handgrip strength. In CF patients, routine use of USG and hand dynamometer may help predict different clinical parameters.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Uslu, N. Z., Kocakaya, D., Olgun Yıldızeli, S., Eryüksel, E., Kenis Coskun, O., Cimsit, C., Görcin Karaketir, S., Ceyhan, B. Tags: Cystic fibrosis Source Type: research

Inspiratory muscle dysfunction relates to clinical disease severity in patients with type I myotonic dystrophy
Conclusions: Inspiratory muscle dysfunction is a common finding in ambulatory DM I patients and proximal muscle weakness should prompt its suspicion.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Spiesshoefer, J., Henke, C., Kabitz, H.-J., Brix, T., Herkenrath, S., Randerath, W., Young, P., Boentert, M. Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research

A characterisation of patients with Antisynthetase Syndrome>
Conclusion: Early, aggressive treatment with immunosuppression is important to provide patients with the best chance of improvement in lung function and outcome.1 www.orpha.net Accessed 14/2/19
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Heiden, E., Titmuss, V., Babu, S. Tags: Rare ILD/DPLD Source Type: research

Home mechanical ventilation in chronic respiratory failure: 10-year mortality
Background: Home mechanical ventilation (HMV) is used in different patient cohorts with chronic hypercapnic respiratory failure. Clinical trials have evaluated the efficacy of HMV in specific subgroups. There are sparse data comparing outcomes in different disease groups on HMV.Methods: All-cause mortality of patients on HMV was documented between 2008 and 2018 in a large tertiary referral centre. Time on HMV until death was compared between patients with neuromuscular disease/chest wall disease (NMD/CWD), obstructive airway disease (OAD), obesity-related respiratory failure (ORRF), overlap syndrome of OAD and OSA (OVERLAP...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Schwarz, E. I., Mackie, M., Weston, N., Tincknell, L., Beghal, G., Cheng, M., Ramsay, M., Suh, E.-S., Kaltsakas, G., Pattani, H., Marino, P., Murphy, P., Hart, N., Steier, J. Tags: Noninvasive ventilatory support Source Type: research