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Total 140 results found since Jan 2013.

The Risk of Ventricular Tachyarrhythmias in Patients with Antimitochondrial Antibodies-Related Noncardiac Diseases
This study aimed to elucidate whether the presence of AMA-related noncardiac diseases indicates VTs risk.This cohort study enrolled 1,613 patients (883 females) who underwent AMA testing to assess noncardiac diseases. The incidence of VTs and supraventricular tachyarrhythmias (SVTs) from a year before the AMA testing to the last visit of the follow-up were retrospectively investigated as primary and secondary objectives. Using propensity score matching, we extracted AMA-negative patients whose covariates were matched to those of 152 AMA-positive patients. In this propensity score-matched cohort, the incidence of VTs and SV...
Source: International Heart Journal - June 1, 2022 Category: Cardiology Authors: Yasuhiro Ikami Daisuke Izumi Yuki Hasegawa Naomasa Suzuki Yuta Sakaguchi Takahiro Hakamata Sou Otsuki Nobue Yagihara Kenichi Iijima Takeshi Kashimura Masaomi Chinushi Tohru Minamino Takayuki Inomata Source Type: research

Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia
CONCLUSIONS AND RELEVANCE: In this exploratory analysis of a US community-based cohort, several echocardiographic measures of lower LA function were significantly associated with an increased risk of subsequent dementia. Measures of LA size were not significantly associated with dementia risk. These findings suggest that impaired LA function may be a risk factor associated with dementia.PMID:35315884 | DOI:10.1001/jama.2022.2518
Source: Atherosclerosis - March 22, 2022 Category: Cardiology Authors: Wendy Wang Michael J Zhang Riccardo M Inciardi Faye L Norby Michelle C Johansen Romil Parikh Jeremy R Van't Hof Alvaro Alonso Elsayed Z Soliman Thomas H Mosley Rebecca F Gottesman Amil M Shah Scott D Solomon Lin Yee Chen Source Type: research

Longitudinal Observational Study of Cardiac Outcome Risk Factor Prediction in Children, Adolescents, and Adults with Barth Syndrome
AbstractBarth Syndrome (BTHS) is an X-linked mitochondrial cardioskeletal myopathy caused by defects inTAFAZZIN, a gene responsible for cardiolipin remodeling. Altered mitochondrial levels of cardiolipin lead to cardiomyopathy (CM), muscle weakness, exercise intolerance, and mortality. Cardiac risk factors predicting outcome are unknown. Therefore, we conducted a longitudinal observational study to determine risk factors for outcome in BTHS. Subjects with minimum two evaluations (or one followed by death or transplant) were included. Cardiac size, function, and QTc data were measured by echocardiography and electrocardiogr...
Source: Pediatric Cardiology - March 3, 2022 Category: Cardiology Source Type: research

Filamin c missense variant associated with severe right atrial disease and skeletal myopathy
ConclusionFilamin C missense variant (c.925G>A p.(Glu309Lys) is associated with severe right atrial disease. Considering co-segregation with the disease (PP1 Supporting), this variant should be classified as likely pathogenic.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - August 19, 2021 Category: Cardiology Authors: Giulio Conte, Flavia Piciacchia, Argelia Medeiros Domingo, Susanna Grego, Paolo Ripellino, Angelo Auricchio Tags: BRIEF COMMUNICATION Source Type: research

Nemaline Rod/Cap Myopathy Due to Novel Homozygous < em > MYPN < /em > Mutations: The First Report from South Asia and Comprehensive Literature Review
CONCLUSIONS: This study elaborates on two patients with homozygous MYPN pathogenic variants, presenting as slowly progressive congenital myopathy. These patients are only the tenth and eleventh cases reported in the English literature, and the first from South Asia. The clinical phenotype reiterates the mild form of nemaline rod/cap myopathy. A comprehensive literature review is presented.PMID:34184449 | DOI:10.3988/jcn.2021.17.3.409
Source: Journal of Clinical Neurology - June 29, 2021 Category: Neurology Authors: Kiran Polavarapu Mainak Bardhan Ram Murthy Anjanappa Seena Vengalil Veeramani Preethish-Kumar Leena Shingavi Tanushree Chawla Saraswati Nashi Dhaarini Mohan Gautham Arunachal Thenral S Geetha Vedam Ramprasad Atchayaram Nalini Source Type: research