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Nutrition: Calcium
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Total 268 results found since Jan 2013.
CALA: Cumulative Volume of Calcified Lesions of the Aorta in Cardiac Surgery
Thorac Cardiovasc Surg. 2022 Jul 11. doi: 10.1055/s-0042-1748194. Online ahead of print.ABSTRACTOne of the major key questions raised in this retrospective study was to identify any correlation of atherosclerotic plaque volume of the ascending aorta and aortic arch with adverse events such as postoperative stroke, critical illness polyneuropathy and myopathy, as well as delirium and all-cause in-hospital mortality. In a second phase of this study, we investigated the relationship between atherosclerotic plaque volume and adverse events regarding the construction of proximal anastomosis on coronary artery bypass grafting pr...
Source: The Thoracic and Cardiovascular Surgeon - July 11, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stelios Ioannou Christian Braun Martin Hartrumpf Ralf-Uwe K ühnel Ali Vafa Filip Schr öter Johannes Albes Source Type: research
The TAM-associated STIM1 < sup > I484R < /sup > mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping
Cell Calcium. 2022 Jun 23;105:102615. doi: 10.1016/j.ceca.2022.102615. Online ahead of print.ABSTRACTTubular aggregate myopathy (TAM) is a progressive skeletal muscle disease associated with gain-of-function mutations in the ER Ca2+ sensor STIM1 that mediates store-operated Ca2+ entry (SOCE) across the Ca2+-release-activated (CRAC) Ca2+ channel ORAI1. A frameshift mutation in STIM1 inactivation domain, STIM1I484R, was identified in a TAM patient and reported to decrease SOCE. Using ion imaging and electrophysiology, we show that the STIM1I484R mutation instead renders STIM1 constitutively active. In ion imaging experiments...
Source: Cell Calcium - July 6, 2022 Category: Cytology Authors: Ji-Hee Kim Amado Carreras-Sureda Monica Didier Christopher Henry Maud Frieden Nicolas Demaurex Source Type: research
Case Report: Novel STIM1 Gain-of-Function Mutation in a Patient With TAM/STRMK and Immunological Involvement
Gain-of-function (GOF) mutations in STIM1 are responsible for tubular aggregate myopathy and Stormorken syndrome (TAM/STRMK), a clinically overlapping multisystemic disease characterised by muscle weakness, miosis, thrombocytopaenia, hyposplenism, ichthyosis, dyslexia, and short stature. Several mutations have been reported as responsible for the disease. Herein, we describe a patient with TAM/STRMK due to a novel L303P STIM1 mutation, who not only presented clinical manifestations characteristic of TAM/STRMK but also manifested immunological involvement with respiratory infections since childhood, with chronic cough and c...
Source: Frontiers in Immunology - June 24, 2022 Category: Allergy & Immunology Source Type: research
Biochemical and Physicochemical Changes in Spaghetti Meat During Refrigerated Storage of Chicken Breast
This study investigated postmortem muscle protein degradation and myowater properties in broiler breasts afflicted with the Spaghetti Meat (SM) myopathy during 7 days of storage. Severe SM and unaffected (NORM) breast fillets were analyzed at days 0, 3, and 7 postmortem for TD-NMR myowater traits, myofibrillar protein profiles, calpain activity, free calcium, and desmin and troponin-T degradation patterns. Only at day 0, muscle histology, fiber size and sarcomere length were assessed on multiple fillet portions. In SM breasts, the intramyofibrillar water population exhibited longer relaxation times (p = 0.0172) and a lowe...
Source: Frontiers in Physiology - June 15, 2022 Category: Physiology Source Type: research
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca < sup > 2+ < /sup > -entry modulators CIC-37 and CIC-39
Cell Calcium. 2022 May 18;105:102605. doi: 10.1016/j.ceca.2022.102605. Online ahead of print.ABSTRACTGain-of-function mutations on STIM1 and ORAI1 genes are responsible for an increased store-operated calcium entry, and underlie the characteristic symptoms of three overlapping ultra-rare genetic disorders (i.e tubular aggregate myopathy, Stormorken syndrome, York platelet syndrome) that can be grouped as tubular aggregate myopathies. These mutations lead to a wide spectrum of defects, which usually include muscle weakness and cramps. Negative modulators of store-operated Ca2+-entry targeting wild-type STIM1 and ORAI1 have ...
Source: Cell Calcium - May 31, 2022 Category: Cytology Authors: Beatrice Riva Emanuela Pessolano Edoardo Quaglia Celia Cordero-Sanchez Irene P Bhela Ana Topf Marta Serafini Daniel Cox Elizabeth Harris Matteo Garibaldi Rita Barresi Tracey Pirali Armando A Genazzani Source Type: research
Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations
Atrial dilation and atrial fibrillation (AF) are common in Hypertrophic CardioMyopathy (HCM) patients and associated with a worsening of prognosis. The pathogenesis of atrial myopathy in HCM remains poorly investigated and no specific association with genotype has been identified. By re-analysis of our cohort of thin-filament HCM patients (Coppini et al. 2014) AF was identified in 10% of patients with sporadic mutations in the cardiac Troponin T gene (TNNT2), while AF occurrence was much higher (25–75%) in patients carrying specific “hot-spot” TNNT2 mutations. To determine the molecular basis of arrhythmia occurrence...
Source: Frontiers in Physiology - April 19, 2022 Category: Physiology Source Type: research
An Investigation of the Altered Textural Property in Woody Breast Myopathy Using an Integrative Omics Approach
The objective of this study was to investigate the functionality/integrity of WB sarcoplasmic reticulum (SR), which may contribute to the elevated calcium content observed in WB and other factors that may influence WB texture. Fourteen Ross line broiler PM [7 severe WB and 7 normal (N)] were selected, packaged, and frozen at −20°C at 8 h postmortem from a commercial processing plant. Samples were used to measure pH, sarcomere length, proteolysis, calpain activity, collagenase activity, collagen content, collagen crosslinks density, and connective tissue peak transitional temperature. Exudate was also collected from ea...
Source: Frontiers in Physiology - March 17, 2022 Category: Physiology Source Type: research
The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ
Biochem Biophys Res Commun. 2021 Dec 17;588:29-33. doi: 10.1016/j.bbrc.2021.12.051. Online ahead of print.ABSTRACTThe molecular mechanisms of pathogenesis of atrial myopathy associated with hypertrophic (HCM) and dilated (DCM) mutations of sarcomeric proteins are still poorly understood. For this, one needs to investigate the effects of the mutations on actin-myosin interaction in the atria separately from ventricles. We compared the impact of the HCM and DCM mutations of tropomyosin (Tpm) on the calcium regulation of the thin filament interaction with atrial and ventricular myosin using an in vitro motility assay. We foun...
Source: Biochemical and Biophysical Research communications - December 23, 2021 Category: Biochemistry Authors: Galina V Kopylova Valentina Y Berg Anastasia M Kochurova Alexander M Matyushenko Sergey Y Bershitsky Daniil V Shchepkin Source Type: research
