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Nutrition: Calcium
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Total 268 results found since Jan 2013.
Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
Am J Physiol Cell Physiol. 2023 Jan 23. doi: 10.1152/ajpcell.00377.2022. Online ahead of print.ABSTRACTDuchenne muscular dystrophy (DMD) is associated with distinct mitochondrial stress responses. Here, we aimed to determine whether the prospective mitochondrial-enhancing compound Olesoxime prevents early-stage mitochondrial stress in limb and respiratory muscle from D2.mdx mice using a proof-of-concept short-term regimen spanning 10-28 days of age. As mitochondrial-cytoplasmic energy transfer occurs via ATP- or phosphocreatine-dependent phosphate shuttling, we assessed bioenergetics with or without creatine in vitro. We o...
Source: American Journal of Physiology. Cell Physiology - January 23, 2023 Category: Cytology Authors: Catherine A Bellissimo Luca J Delfinis Meghan C Hughes Patrick C Turnbull Shivam Gandhi Sara N DiBenedetto Fasih A Rahman Peyman Tadi Christina A Amaral Ali Dehghani James Cobley Joe Quadrilatero Uwe Schlattner Christopher G R Perry Source Type: research
A vascular smooth muscle-specific integrin- α8 Cre mouse for lymphatic contraction studies that allows male-female comparisons and avoids visceral myopathy
Discussion: Our results demonstrate that Itga8-CreERT2 can be used to effectively delete genes in lymphatic smooth muscle while avoiding potentially lethal visceral myopathy and allowing comparative studies of lymphatic contractile function in both male and female mice.
Source: Frontiers in Physiology - January 12, 2023 Category: Physiology Source Type: research
Store-operated calcium entry: From physiology to tubular aggregate myopathy
Curr Opin Pharmacol. 2023 Jan 4;68:102347. doi: 10.1016/j.coph.2022.102347. Online ahead of print.ABSTRACTStore-Operated Ca2+ entry (SOCE) is recognized as a key mechanism in muscle physiology necessary to refill intracellular Ca2+ stores during sustained muscle activity. For many years the cell structures expected to mediate SOCE in skeletal muscle fibres remained unknown. Recently, the identification of Ca2+ Entry Units (CEUs) in exercised muscle fibres opened new insights into the role of extracellular Ca2+ in muscle contraction and, more generally, in intracellular Ca2+ homeostasis. Accordingly, intracellular Ca2+ unba...
Source: Current Opinion in Pharmacology - January 6, 2023 Category: Drugs & Pharmacology Authors: Feliciano Protasi Barbara Girolami Sara Roccabianca Daniela Rossi Source Type: research
A Novel De Novo Frameshift Pathogenic Variant in the FAM111B Resulting in Progressive Osseous Heteroplasia Phenotype
ConclusionThis is the first case of POH phenotype associated with a novel de novo pathogenic frameshift variant inFAM111B. Whether the frameshift change inFAM111B predicts POH remains unclear. Further evaluations are necessary to fully elucidate this finding and the potential role and mechanism by which theFAM111B variants contributes to POH phenotype.
Source: Calcified Tissue International - December 27, 2022 Category: Orthopaedics Source Type: research
Disrupted T-tubular network accounts for asynchronous calcium release in MTM1 deficient skeletal muscle
This article is protected by copyright. All rights reserved.PMID:36408764 | DOI:10.1113/JP283650
Source: The Journal of Physiology - November 21, 2022 Category: Physiology Authors: Peter Szentesi Beatrix Dienes Candice Kutchukian Tamas Czirjak Ana Buj-Bello Vincent Jacquemond Laszlo Csernoch Source Type: research
