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Angioinvasive gastrointestinal mucormycosis with duodenal necrosis and perforation in a patient with visceral myopathy
Z Gastroenterol. 2023 Apr 12. doi: 10.1055/a-2053-9149. Online ahead of print.ABSTRACTA 55-year-old woman with a past medical history of visceral myopathy with multiple resultant abdominal surgeries, colectomy caused by severe pseudo-obstruction, and end-stage renal disease on hemodialysis presented with complaints of nausea, abdominal distention, vomiting, and diarrhea for five days. Small-bowel obstruction was identified on CT. She subsequently developed acute gastrointestinal bleeding, anemia, and hemodynamic instability. Extensive gastric ulceration with frank hemorrhage prompted urgent subtotal gastrectomy with multip...
Source: Zeitschrift fur Gastroenterologie - April 12, 2023 Category: Gastroenterology Authors: Nicole Hunter Alexander Kusnik Layla Hatem Ari Chodos Anthony Baratta Prasad Penmetsa Yana Levin Source Type: research

Pneumocystis jirovecii Pneumonia in Neurologic Disorders: Is Prophylaxis Necessary?
Conclusions The overall incidence of PJP in patients with non-neoplastic neurologic disorders is exceedingly low, raising doubt about the value of routine PJP prophylaxis in neurologic patients outside neuro-oncology. PJP infection occurs frequently in patients with malignancy or parenchymal organ failure, indicating that overall health status may serve as a predisposing factor for PJP.
Source: Neurology Clinical Practice - June 7, 2021 Category: Neurology Authors: Pike-Lee, T., Syed, S., Willis, M. A., Li, Y. Tags: Autoimmune diseases, Fungal infections, Myasthenia, Primary brain tumor Research Source Type: research

Unabridged histoplasmosis myositis: Unsolved dissemination with diagnostic challenge
Gurparvesh S Goraya, Guneet Sidhu, Updesh Sidhu, Birinder S Paul, Gunchan PaulAnnals of Indian Academy of Neurology 2021 24(2):239-242 Histoplasmosis occurs predominantly in immunocompromised hosts and typically presents with mild constitutional symptoms, weight loss, weakness, fatigability, hepatosplenomegaly, and lymphadenopathy. The diagnosis is generally delayed and is based upon isolating the organism in blood cultures or by identifying intracellular organisms in tissues. Disseminated Histoplasmosis is well described in HIV patients but Histoplasmosis myositis is a rare manifestation and has not been reported in sero...
Source: Annals of Indian Academy of Neurology - April 28, 2021 Category: Neurology Authors: Gurparvesh S Goraya Guneet Sidhu Updesh Sidhu Birinder S Paul Gunchan Paul Source Type: research

Neurological Adverse Events Determine Morbidity and Mortality Post Allogeneic Hematopoietic Cell Transplantation
Conclusions: Our large retrospective study highlights the wide spectrum of manifestations and etiologies of neurological complications in alloHCT recipients. Prompt diagnosis is required for adequate management, a major of determinant of survival. Thus, long-term increased awareness and collaboration between expert physicians is warranted to improve patient outcomes.Figure.DisclosuresGavriilaki: European Hematology Association: Research Funding. Vardi: Janssen: Honoraria; Gilead: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Sakellari, I., Gavriilaki, E., Papagiannopoulos, S., Gavriilaki, M., Batsis, I., Mallouri, D., Vardi, A., Constantinou, V., Iskas, M., Masmanidou, M., Yannaki, E., Geroukis, T., Kazis, D., Kimiskidis, V., Anagnostopoulos, A. Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence Source Type: research

Neurological complications in renal transplant patients: A single-center experience
Conclusion We conclude that complications involving the neurological system occur in 10.5% of all transplant patients with 8% involving CNS and 7% involving the PNS. The high mortality rates associated with CNS complications warrant early diagnosis and aggressive treatment in renal transplant recipients.
Source: Indian Journal of Transplantation - November 24, 2015 Category: Transplant Surgery Source Type: research

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency
Stromal interaction molecule 1 (STIM1) is a transmembrane protein pivotal to store-operated calcium entry (SOCE) that localizes to either the cell or endoplasmic reticulum (ER) membranes, with the N-terminus in either the extracellular space or the ER, respectively. Plasma membrane ORAI calcium release–activated calcium modulator 1 (ORAI1) Ca2+ channels are activated by STIM1. Families previously described with recessive STIM1 mutations (MIM #612783) had life-threatening viral, bacterial, and fungal infections; developmental myopathy; hypohidrosis; and amelogenesis imperfecta (AI; generalized developmental enamel abnormalities).
Source: Journal of Allergy and Clinical Immunology - November 9, 2015 Category: Allergy & Immunology Authors: David A. Parry, Tim D. Holmes, Nikita Gamper, Walid El-Sayed, Nishani T. Hettiarachchi, Mushtaq Ahmed, Graham P. Cook, Clare V. Logan, Colin A. Johnson, Shelagh Joss, Chris Peers, Katrina Prescott, Sinisa Savic, Chris F. Inglehearn, Alan J. Mighell Tags: Letter to the editor Source Type: research

A homozygous mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency
Stromal interaction molecule 1 (STIM1) is a transmembrane protein pivotal to store-operated calcium entry (SOCE) that localizes to either the cell or endoplasmic reticulum (ER) membranes, with the N-terminus in either the extracellular space or the ER, respectively. Plasma membrane ORAI calcium release–activated calcium modulator 1 (ORAI1) Ca2+ channels are activated by STIM1. Families previously described with recessive STIM1 mutations (MIM #612783) had life-threatening viral, bacterial, and fungal infections; developmental myopathy; hypohidrosis; and amelogenesis imperfecta (AI; generalized developmental enamel abnormalities).
Source: Journal of Allergy and Clinical Immunology - November 9, 2015 Category: Allergy & Immunology Authors: David A. Parry, Tim D. Holmes, Nikita Gamper, Walid El-Sayed, Nishani T. Hettiarachchi, Mushtaq Ahmed, Graham P. Cook, Clare V. Logan, Colin A. Johnson, Shelagh Joss, Chris Peers, Katrina Prescott, Sinisa Savic, Chris F. Inglehearn, Alan J. Mighell Tags: Letter to the Editor Source Type: research

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