• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxvn Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research

Case report: Discovery of a de novo FAM111B pathogenic variant in a patient with an APECED-like clinical phenotype
This report expands upon the available genetic, clinical, autoantibody, immunological, and treatment response information on POIKTMP.
Source: Frontiers in Immunology - February 17, 2023 Category: Allergy & Immunology Source Type: research

Telbivudine-Induced Myopathy: Clinical Features, Histopathological Characteristics, and Risk Factors
CONCLUSIONS: Mitochondrial abnormalities are characteristic histopathological features, and impaired renal function and HBeAg positivity are risk factors for TIM. Telbivudine-induced mitochondrial dysfunction and immune activation related to mitochondrial damage and HBeAg serostatus changes may underlie TIM. Constant clinical surveillance of myopathy during telbivudine treatment is needed due to the significant latency of its development. Dose adjustment for impaired renal function does not eliminate the risk of TIM occurrence.PMID:36606646 | DOI:10.3988/jcn.2023.19.1.52
Source: Journal of Clinical Neurology - January 6, 2023 Category: Neurology Authors: Min-Yu Lan Hui-Chen Lin Tsung-Hui Hu Shu-Fang Chen Chien-Hung Chen Yung-Yee Chang King-Wah Chiu Tsu-Kung Lin Shun-Sheng Chen Source Type: research

Effects of rosuvastatin/ezetimibe on senescence of CD8+ T-cell in type 2 diabetic patients with hypercholesterolemia: A study protocol
Discussion: We will evaluate the effects of statin/ezetimibe on CD8 + T cell senescence. Statin/ezetimibe may exert a beneficial immunomodulatory effect.
Source: Medicine - November 25, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Elevation of serum creatine kinase induced by anti-thyroid drugs: Two case reports and a literature review
Int J Clin Pharmacol Ther. 2022 Sep 2. doi: 10.5414/CP204269. Online ahead of print.ABSTRACTAnti-thyroid drugs (ATDs), such as methimazole (MMI) and propylthiouracil (PTU), are the most common treatment options for hyperthyroidism. Although effective, well-known adverse effects include agranulocytosis, toxic hepatitis, vasculitis, and arthralgias. Myalgia and elevation of serum creatine kinase (CK) are relatively rare, with an unclear mechanism. Rapid decrease in the thyroid hormone level may be associated with ATD-related myopathy; however, direct effects of the drug on muscle tissue cannot be excluded. Here we report on ...
Source: Clinical Pharmacology and Therapeutics - September 2, 2022 Category: Drugs & Pharmacology Authors: Yuqi Si Fenli Su Haoxiang Wu Chuangpeng Shen Source Type: research

Pages: 1  2  3  4  5  6