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Therapy: Stem Cell Therapy
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Total 790 results found since Jan 2013.
CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin
Chemosphere. 2022 Jul 4:135578. doi: 10.1016/j.chemosphere.2022.135578. Online ahead of print.ABSTRACTOverexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression of ssDNA and the related antigens in the population and brisk activity in gene-edit...
Source: Chemosphere - July 7, 2022 Category: Chemistry Authors: Navid Rabiee Omid Akhavan Yousef Fatahi Amir Mohammad Ghadiri Mahsa Kiani Pooyan Makvandi Mohammad Rabiee Mohammad Hossein Nicknam Mohammad Reza Saeb Rajender S Varma Milad Ashrafizadeh Ehsan Nazarzadeh Zare Esmaeel Sharifi Eder C Lima Source Type: research
Association between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends
Biomed Res Int. 2022 Jun 22;2022:9346939. doi: 10.1155/2022/9346939. eCollection 2022.ABSTRACTBACKGROUND: The novel coronavirus first emerged in Wuhan, China, and quickly spread across the globe, spanning various countries and resulting in a worldwide pandemic by the end of December 2019. Given the current advances in treatments available for COVID-19, mesenchymal stem cell (MSC) therapy seems to be a prospective option for management of ARDS observed in COVID-19 patients. This present study is aimed at exploring the therapeutic potential and safety of using MSC obtained by isolation from health cord tissues in the treatme...
Source: Biomed Res - July 5, 2022 Category: Research Authors: Amaan Javed Saurab Karki Zeba Sami Zuha Khan Anagha Shree Biki Kumar Sah Shankhaneel Ghosh Sara Saxena Source Type: research
Tissue Repair Strategies: What We Have Learned From COVID-19 in the Application of MSCs Therapy
Pharmacol Res. 2022 Jun 29;182:106334. doi: 10.1016/j.phrs.2022.106334. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) infection evokes severe proinflammatory storm and pulmonary infection with the number of confirmed cases (more than 200 million) and mortality (5 million) continue to surge globally. A number of vaccines (e.g., Moderna, Pfizer, Johnson/Janssen and AstraZeneca vaccines) have been developed over the past two years to restrain the rapid spread of COVID-19. However, without much of effective drug therapies, COVID-19 continues to cause multiple irreversible organ injuries and is drawing inten...
Source: Cell Research - July 2, 2022 Category: Cytology Authors: Yiran E Li Amir Ajoolabady Muralikrishnan Dhanasekaran Jun Ren Source Type: research
Conserved 3 ′ UTR of Severe Acute Respiratory Syndrome Coronavirus 2: Potential Therapeutic Targets
Our previous paper showed that microRNAs (miRNAs) present within human placental or mesenchymal stem cell-derived extracellular vesicles (EVs) directly interacted with the RNA genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), inhibiting viral replication. In this paper, we analyzed whether these miRNAs could exert antiviral activity against other variants of SARS-CoV-2. We downloaded compete SARS-CoV-2 genome data submitted to the National Center for Biotechnology Information for each SARS-CoV-2 variant, aligned the data to the reference SARS-CoV-2 genome sequence, and then confirmed the presence of 3...
Source: Frontiers in Genetics - June 30, 2022 Category: Genetics & Stem Cells Source Type: research
Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency
In this study we evaluated humoral and T cell-mediated responses against severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) with additional flow cytometric changes in CVID patients receiving booster vaccination with BNT162b2 after two ChAdOx1 nCoV-19. The BNT162b2 vaccine raised the anti-spike protein S immunoglobulin G over the cut-off value from 70% to 83% in CVID, anti-neutralizing antibody had been raised over a cut-off value from 70% to 80% but levels after boosting were significantly less in both tests than in healthy controls (*p=0.02; **p=0.009 respectively). Anti-SARS-CoV-2 immunoglobulin A became less p...
Source: Frontiers in Immunology - June 17, 2022 Category: Allergy & Immunology Source Type: research
Predictors of Covid-19 Vaccination Response after in-vivo T-cell depleted Stem Cell Transplantation
New York City was the epicenter of a severe outbreak of coronavirus 19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) starting in March 2020.1 The initial death rates among patients with hematological malignancies were high.2-4 Although vaccination was rapidly developed, immunosuppressed patients were excluded from the initial studies; questions regarding efficacy and tolerance in these populations are only now being addressed. Responses in patients with hematological malignancies are particularly poor among patients with chronic lymphocytic leukemia and myeloma and further weakened upon ...
Source: Biology of Blood and Marrow Transplantation - June 17, 2022 Category: Hematology Authors: Ok-kyong Chaekal, Alexandra Gomez-Arteaga, Zhengming Chen, Rosemary Soave, Tsiporah Shore, Sebastian Mayer, Adrienne Phillips, Jing Mei Hsu, Alex Drelick, Rosy Priya L. Kodiyanplakkal, Markus Plate, Michael J. Satlin, Koen van Besien Source Type: research
Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes
CONCLUSION: Transcriptional profiling in hiPSC-CMs treated with COVID-19 drugs identified unfavorable changes with lopinavir/ritonavir and lopinavir/ritonavir/INF-β in key cardiac gene programs that may negatively affect heart function.PMID:35686037 | PMC:PMC9170897 | DOI:10.3389/fcvm.2022.844441
Source: Methods of Information in Medicine - June 10, 2022 Category: Information Technology Authors: Tobias Jakobi Julia Gro ß Lukas Cyganek Shirin Doroudgar Source Type: research
Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially described to target the respiratory system and now has been reported to infect a variety of cell types, including cardiomyocytes, neurons, hepatocytes, and gut enterocytes. However, it remains unclear whether the virus can directly infect human embryonic stem cells (hESCs) or early embryos. Herein, we sought to investigate this question in a cell-culture system of hESCs. Both the RNA and S protein of SARS-CoV-2 were detected in the infected hESCs and the formation of syncytium was observed. The increased level of subgenomic viral RNA and the pre...
Source: Frontiers in cellular and infection microbiology - June 10, 2022 Category: Microbiology Source Type: research
